Clinical value ofHelicobacter pyloristool antigen test, ImmunoCard STAT HpSA, for detectingH pyloriinfection

Li, Yihui; Guo, Hong; Zhang, Pengbin; Zhao, Xiaoyan; Da, Si-Ping

doi:10.3748/wjg.v10.i6.913

Cited by 34 publications

(19 citation statements)

References 15 publications

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“…Although this permits us to think that this large difference is related to antigenic diversity between the two strains, it would be a premature conclusion, since the methods of evaluation were different; furthermore, more analysis with larger numbers of H. pylori strains is required to determine the analytical sensitivity for an HpSA test. A variety of experiments have been performed with HpSA tests, including Premier Platinum HpSA, Immuno Card STAT HpSA, and FemtoLab H. pylori CnX (1,2,12,15,16,18,20,(39)(40)(41). However, no uniformity was observed in different populations in regard to the cutoff level required to consider the test positive or negative.…”

Section: Discussionmentioning

confidence: 99%

“…The H. pylori stool antigen test has been introduced as a noninvasive, simple, relatively inexpensive, and reliable assay in the diagnosis of H. pylori infection of gastritis or peptic ulcer in adults and children (1,2,15,17). Although it is not yet at the level to replace histology as a gold standard, it may be a promising tool in detection of H. pylori infection and could be used in the follow-up of adults and children undergoing antibiotic therapy (5,8,12,18,20,23,24,29,32,33,38,39,41).The purpose of this work was to perform an evaluation of the H. pylori infection incidence in children and adolescents from Tehran, Iran, by using an HpSA test (Equipar, Italy). …”

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confidence: 99%

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Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Falsafi

Valizadeh

Sepehr

et al. 2005

Clin Vaccine Immunol

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Helicobacter pylori infection is acquired mainly in childhood, especially in developing countries, where a low-cost, rapid diagnostic technique which is reliable for all age groups may be useful for the management of H. pylori infection. For this purpose, we used an HpSA test (Equipar) to detect H. pylori infection in children and adolescents from Tehran, Iran. Thirty-five children who were positive or negative for H. pylori infection by endoscopy-based tests were used as positive and negative controls for the HpSA test. Stools were collected from 430 randomly selected children and adolescents (4 to 18 years old) from southwest, near the center, and northwest of Tehran. A questionnaire that included presence of recurrent abdominal pain (RAP), family history of infection and/or peptic ulcer disease (PUD), and income of parents was completed. A good agreement was found between the results of endoscopy-based tests and those of the HpSA test; the sensitivity and specificity of the Equipar-HpSA test were 100% and 83.4%, respectively. Among 430 children and adolescents, 47% were positive by the HpSA test, of whom 82% had RAP. No difference in incidence was observed between the two sexes; the various categories of age showed an increasing incidence, ranging from 24% (ages 4 to 6) to 58% (ages 16 to 18). The rate of infection in children and adolescents from the southwest was significantly higher (70%) than the rate in those from the northwest (32%), and a family history of H. pylori infection or PUD was observed in 59% of the HpSA positive subjects. The HpSA test is a useful test to detect H. pylori infection in children and adolescents from developing countries.Helicobacter pylori infection is acquired mainly in childhood, especially in developing countries (40), where the influence of socioeconomic factors on the prevalence of H. pylori infection has been shown (11,30,37). Many investigators have studied the criteria for diagnosis and treatment of children infected by H. pylori, but association of symptoms with H. pylori infection in children presenting with nonulcer dyspepsia is controversial (3,14,22). One important controversy relates to the presence of recurrent abdominal pain (RAP) in children, where an important association was observed between RAP and H. pylori infection in some populations (4,10,19,27,28,31,34). Although endoscopy-based tests are the best methods to diagnose active H. pylori infection, their application in children is more difficult and unpleasant than in adults. Moreover, in developing regions, for socioeconomic reasons, most infected children are not diagnosed and/or treated for H. pylori infection. To circumvent these difficulties, a noninvasive test with reliability for all age groups of children and adolescents is required. Among the noninvasive methods, serological tests cannot be applied to young children because of low sensitivity. In addition, the 13 C urea breath test is cumbersome, expensive, and consequently unavailable in certain countries; furthermore, it is not reliable in very...

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Falsafi

Valizadeh

Sepehr

et al. 2005

Clin Vaccine Immunol

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“…Previous reports show that age, race, living in rural area, overcrowding, socioeconomic status, poor sanitary conditions, mothers with lower educational level, poor diet and poor water supply are some of the important risk factors for transmission of H. pylori [1] [2] [12] [13] [14]. Prevalence of H. pylori infection in developing countries is higher compared with developed countries [15].…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of Helicobacter pylori Infection and Risk Factors among Asymptomatic Subjects in Delta State, Nigeria

Omosor¹,

Omosor²,

Ibeh³

et al. 2017

AiM

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Aim: The study aimed at evaluating the seroprevalence of H. pylori infection and its associated risk factors in a cross-section of asymptomatic adult population in Niger-Delta, Nigeria. Methodology: 408 apparently healthy volunteers, aged between 18 -87 years were recruited for this study. Blood samples were collected from participants and analyzed for H. pylori antibody (IgG) qualitatively with Combo rapid kits and quantitatively with Accu-Bind ELISA Kits. Results: The overall prevalence of Helicobacter pylori colonization in 408 asymptomatic adults was 52.5% (n = 214) and 48.3% (n = 197) by qualitative (Combo rapid kits) and quantitative (Accu-Bind ELISA Kits) serological test methods respectively. H. pylori infection did not differ statistically between genders (p = 0.962) and among age groups (p = 0.185). In addition, multivariate logistic regression indicated that sex and age were not associated with risk of H. pylori. However, participants from Delta Central were at greater risk (OR = 1.89; p = 0.014) of H. pylori infection compared with those from Delta South, but those from Delta North were not at greater risk of infection compared with those from Delta South (p = 0.476). Conclusion: This study indicated an intermediate seroprevalence of H. pylori among asymptoHow to cite this paper: Omosor, K.I.,

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“…In our own experience [35] , and based on other reports made of an Asian population [34,36] , the diagnostic efficacy of Premier Platinum HpSA® has been less consistent in an Asian population. However, there is a new stool antigen test, ImmunoCard HpSA STAT®, which seems to have higher diagnostic accuracy in Asian population [38] . In conclusion, URINELISA test is reliable, inexpensive and easy-to-use, and its high degree of diagnostic accuracy warrants its use as a first-line screening tool for the diagnosis of H pylori infection in untreated patients.…”

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Evaluation of urine ELISA test for detectingHelicobacter pyloriinfection in Taiwan: A prospective study

Kuo

Wang²,

Wu³

et al. 2005

WJG

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AIM:To evaluate the diagnostic accuracy and clinical utility of a new ELISA (URINELISA) test for detecting Helicobacter pylori (H pylori) antibody in the urine of Taiwanese population. METHODS:In this prospective study, 317 consecutive dyspeptic patients (171 men, 146 women; mean age, 51.0 years) were included. They underwent gastroendoscopy for evaluation. Invasive tests, including culture, histology, and rapid urease test (RUT), and non-invasive 13 C-urea breath test were preformed. At the same time, urine specimens were collected for URINELISA. The status of H pylori infection was considered as positive when either culture was positive, or when two of the other, RUT, histology or 13C-UBT, were positive. RESULTS:The sensitivity, specificity, positive predictive value, and negative predictive value of URINELISA are 91.7% (211/230), 90.8% (79/87), 96.3% (211/219), and 80.6% (79/98) respectively. CONCLUSION:This URINELISA test is reliable, inexpensive and easy-to-use. The high diagnostic accuracy warrants the use of URINELISA as a first-line screening tool for diagnosis of H pylori infection in untreated patients.

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Clinical value ofHelicobacter pyloristool antigen test, ImmunoCard STAT HpSA, for detectingH pyloriinfection

Cited by 34 publications

References 15 publications

Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Seroprevalence of <i>Helicobacter pylori</i> Infection and Risk Factors among Asymptomatic Subjects in Delta State, Nigeria

Evaluation of urine ELISA test for detectingHelicobacter pyloriinfection in Taiwan: A prospective study

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Clinical value ofHelicobacter pyloristool antigen test, ImmunoCard STAT HpSA, for detectingH pyloriinfection

Cited by 34 publications

References 15 publications

Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Application of a Stool Antigen Test To Evaluate the Incidence ofHelicobacter pyloriInfection in Children and Adolescents from Tehran, Iran

Seroprevalence of &lt;i&gt;Helicobacter pylori&lt;/i&gt; Infection and Risk Factors among Asymptomatic Subjects in Delta State, Nigeria

Evaluation of urine ELISA test for detectingHelicobacter pyloriinfection in Taiwan: A prospective study

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Seroprevalence of <i>Helicobacter pylori</i> Infection and Risk Factors among Asymptomatic Subjects in Delta State, Nigeria