Clinical value of Flash glucose monitoring in patients with type 1 diabetes treated with continuous subcutaneous insulin infusion

Assessment of FreeStyle Libre Flash Glucose Monitoring System Implementation in Real Life Clinical Setting: A Prospective Observational Study

“…The results of this study confirm what has already been shown in numerous trials [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. The simplicity and ease of use of the FGM system which was confirmed by frequent scans on daily basis exactly according to the recommendations, even increasing slightly by the end of one year indicating high level of adherence and compliance resulting in the improvement of HbA1c.…”

“…There was a decrease in HbA1c in the entire cohort of patients occurring in the first 3 months with no further changes to the end of one year confirming that majority of improvement in glucoregulation is taking place at the very beginning of FGM implementation in glycemic management, supporting evidence of presently published observational trials [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. As the FGM metrics were not available at baseline, data from T3 to 12 were analyzed showing a significant increase in the time spent in range (TIR) and significant decrease in time spent in hyperglycemia (TAR).…”

“…In the landmark RCTs of FGM efficacy a change in HbA1c has not been observed [ 1 , 2 ]. On the other hand, the majority of observational studies conducted in routine clinical practice have reported a significant reduction in HbA1c with the usage of FGM [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ]. Furthermore, recently published studies suggested that patients with good glycemic control have no benefits from FGM use, while those with suboptimal control tend to reach significant improvement in HbA1c levels probably due to the higher motivation and empowerment of patients in therapeutic decision making [ 8 , 10 , 11 , 16 ].…”

Expert Panel Recommendations for Use of Standardized Glucose Reporting System Based on Standardized Glucometrics Plus Visual Ambulatory Glucose Profile (AGP) Data in Clinical Practice

“…In a 24-week study by Moreno-Fernandez et al. in T1DM patients, significant change in HbA1c (−0.4% vs. 0.1%) and decrease in SMBG per day (from 5.2 ± 2.5 to 2.8 ± 1.7) were noted in FGM users (n = 18) vs. control (n = 18) group with no significant difference between groups in frequency of hypoglycemic episodes ( 62 )…”

“…GMI can help patients and HCPs monitor progress but should not replace lab A1c tests ( 62 ). Differences between the GMI and laboratory measured A1C may reflect several conditions as summarized in Figure 2 ( 76 ).…”