Clinical value of CYFRA 21.1, carcinoembryonic antigen, neurone-specific enolase, tissue polypeptide specific antigen and tissue polypeptide antigen in the diagnosis of lung cancer

Bates, John; Rutherford, Richard A.D.; Divilly, M; Finn, J.L.; Grimes, H.; O’Muircheartaigh, I. G.; Gilmartin, J J

doi:10.1183/09031936.97.10112535

Cited by 36 publications

(34 citation statements)

References 19 publications

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“…While high specificities were found (more than 90%) in our study, the sensitivities of those four tumor markers were unsatisfactory (less than 30%), which was consistent with other studies. [23][24][25][26] However, it appeared that the sensitivities of tumor markers were lower than those reported by others (7.4-24.1 vs. 25.5-66.5%). 21,27 This might be the fact that the majority (67.4%) of lung cancer group were early-staged in our study.…”

contrasting

confidence: 45%

Diagnostic values of SCC, CEA, Cyfra21-1 and NSE for lung cancer in patients with suspicious pulmonary masses: A single center analysis

Chu¹,

Hou²,

Song³

et al. 2011

Cancer Biology & Therapy

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contrasting

confidence: 45%

Diagnostic values of SCC, CEA, Cyfra21-1 and NSE for lung cancer in patients with suspicious pulmonary masses: A single center analysis

Chu¹,

Hou²,

Song³

et al. 2011

Cancer Biology & Therapy

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“…The overexpression and elevated serum levels of phosphoglycerate kinase 1 are shown in pancreatic ductal adenocarcinoma (35). Moreover, serum ENO2 is considered to be a prognostic factor in small cell lung, breast, and prostrate cancer (36)(37)(38)(39). Finally, PKM2 seems to be a more sensitive marker than conventional tumor markers such as CEA and CA72-4 for the post-operative surveillance of gastrointestinal cancer (40)(41)(42)(43)(44).…”

Section: Discussionmentioning

confidence: 99%

Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers

Yeh

Wang²,

Chung³

et al. 2008

Oncol Rep

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Abstract. We investigated gene expressions involved in the glycolytic pathways in colorectal cancer. The study was designed to use gene ontology and its relevant bioinformatics tools to analyze the microarray data obtained from CRC tissues and their corresponding normal tissues, in order to explore the correlation between the glycolytic metabolic pathway and possible pathogenesis of this disease. The overexpression of glycolysis-related genes was observed in over 76% of CRC tissues. In addition, we stimulated the SW480 and SW620 CRC cell lines with 15 mM D-(+)-glucose and 10 mM 2-deoxy-D-glucose respectively. The results indicate that the proliferation response of both the SW480 and SW620 cell lines increased remarkably with a time-dependent effect by D-(+)-glucose administration. In contrast, the proliferation response of both the SW480 and SW620 cell lines was significantly inhibited by 2-DG administration. Likewise, further analyses of the expression of related genes triggered by the D-(+)-glucose in vivo show that the activation process of these eight genes -GLUT1, HK1, GPI, GAPD, PGK1, PGK2, ENO2, PKM2 -prominently increased with a timedependent effect. In conclusion, this study demonstrates that the glycolytic pathway and glycolysis-related genes may play an important role in the tumorigenesis of CRC, but their molecular mechanisms need further investigation to verify this.

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“…Similar studies have shown that increasing the number of samplings (repeated sampling in several sessions) significantly increases the sensitivity of mRNA biomarkers [29] [30]. This indicates that the odds of detecting markers are lower in a single sampling.…”

Section: Discussionmentioning

confidence: 54%

“…In this study, we evaluated the expression of CEA mRNA and MUC1 mRNA in [29]. A number of nonsmall cell lung cancer patients who are recognized in primary stages of the disease and undergo surgery die due to tumor recurrence, which shows presence of undetectable metastasis at the time of surgery.…”

Section: Discussionmentioning

confidence: 99%

Two Molecular Markers of Early Non-Small Cell Lung Carcinoma Based on Gene Expression in Peripheral Blood

Bahrami¹,

Jamaati²,

Nia³

et al. 2017

OJCD

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Background: Lung cancer is among the most common cancers. Search is ongoing to find biomarkers to improve the diagnosis lung cancer techniques in early stages. In this study we evaluate the sensitivity and specificity of the MUC1 and CEA gene expressions in the peripheral blood of non-small cell lung cancer (NSCLC). Material and Methods: This study was done in Masih Daneshvari Hospital, Tehran, Iran and was case/control study that conducted on 30 NSCLC patients and 30 healthy controls. Peripheral blood was collected and total RNA was extracted then cDNA was synthesized. Sample was separately assessed by real time PCR. Results: The expression of CEA gen was positive in 24 patients indicating 80% sensitivity for this marker. The expression of CEA gen was positive in 9 controls out of 30 each. A statistically significant difference was detected between patients and healthy controls with regard to CEA mRNA expression (P < 0.001). The MUC1 gen expressed in 20 out of 30 patients, while it expressed in 3 controls. The difference in MUC1 mRNA expression was statistically significant between NSCLC patients and How to cite this paper:

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Clinical value of CYFRA 21.1, carcinoembryonic antigen, neurone-specific enolase, tissue polypeptide specific antigen and tissue polypeptide antigen in the diagnosis of lung cancer

Cited by 36 publications

References 19 publications

Diagnostic values of SCC, CEA, Cyfra21-1 and NSE for lung cancer in patients with suspicious pulmonary masses: A single center analysis

Diagnostic values of SCC, CEA, Cyfra21-1 and NSE for lung cancer in patients with suspicious pulmonary masses: A single center analysis

Significance of the glycolytic pathway and glycolysis related-genes in tumorigenesis of human colorectal cancers

Two Molecular Markers of Early Non-Small Cell Lung Carcinoma Based on Gene Expression in Peripheral Blood

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