“…There were seven nested case-control studies [21,22,29,30,31,32,33,34] and three retrospective case-control studies [23,24,25]. Nine articles described the association between IGF-I concentration and PaC risk [21,22,23,24,25,30,31,32,33], three described the association between IGF-II concentration and PaC risk [22,30,31], six reported the association between IGFBP-3 concentration and PaC risk [21,22,30,31,32,33], while four reported the association between the IGF-I/IGFBP-3 ratio and PaC risk [21,22,30,32]. The average score for the quality assessment of included studies was 7.9 (Table 1).…”