Clinical value of a diagnostic score for colon cancer based on serum CEA, CA19-9, cytokeratin-1 and mucin-1

Attallah, A.M.; El‐Far, Mohamed; Ibrahim, AR; El-Desouky, Mohamed A.; Omran, M M; Elbendary,; Attallah, KA; Qura, ER; Abdallah, Sanaa O.

doi:10.1080/09674845.2018.1456309

Cited by 26 publications

(25 citation statements)

References 27 publications

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“…This is consistent with other studies [30,31]. There are also inconsistencies with some studies [29,32].…”

Section: Discussionsupporting

confidence: 88%

Clinical Diagnostic Value for Colorectal cancer Based on Serum CEA, CA24-2 and CA19-9

Rao

Huang

et al. 2020

Preprint

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Background To explore the clinical value of a combined detection of serum concentration of carcinoembryonic antigen (CEA), carbohydrate antigen 24-2 (CA24-2), and carbohydrate antigen 19-9 (CA19-9) for colorectal cancer (CRC).Methods The levels of serum tumor markers (CEA, CA24-2 and CA19-9) and clinicopathologic features in patients with colorectal cancer in Meizhou People's Hospital were evaluated. In addition, KRAS/NRAS, PIK3CA and BRAF mutations were detected in some patients with colorectal cancer.Results A total of 2,281 patients (1,420 males and 861 females) were recruited in the study, included 1,578 colorectal cancer patients and 703 controls. The levels of CEA, CA24-2 and CA19-9 in colorectal cancer group was significantly higher than control group. The sensitivities of three individual markers were lower than 30%, which individual sensitivity of the tumor markers sorted in descending order were CEA> CA19-9> CA24-2. The specificities of three individual markers were more than 92%, and the specificity sorted in descending order were CA24-2> CA19-9> CEA. The prediction equation excluding the risk of colorectal cancer was. Probability (normal) = Exp (-5.47 -0.28CEA -0.11 CA242 + 0.001 CA199)/ (1+ Exp (-5.47 -0.28CEA -0.11 CA242 + 0.001 CA199)). There were no significant differences in age, gender, histology type, differentiation, depth of invasion and TNM stage between mutations in KRAS/NRAS , BRAF and PIK3CA genes or not, respectively.Conclusions Serum CEA, ca24-2, and ca19-9 are valuable noninvasive indicators for the detection and screening of patients with early colon cancer. We need to look for other, more sensitive tumor markers.

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“…This is consistent with other studies [30,31]. There are also inconsistencies with some studies [29,32].…”

Section: Discussionsupporting

confidence: 88%

Clinical Diagnostic Value for Colorectal cancer Based on Serum CEA, CA24-2 and CA19-9

Rao

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…This is consistent with other studies [38,39]. There are also inconsistencies with some studies [37,40].…”

Section: Discussionsupporting

confidence: 88%

Clinical Diagnostic Value for Colorectal Cancer Based on Serum CEA, CA24-2 and CA19-9

Rao

Huang

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background To explore the clinical value of a combined detection of serum concentration of carcinoembryonic antigen (CEA), carbohydrate antigen 24-2 (CA24-2), and carbohydrate antigen 19-9 (CA19-9) for colorectal cancer (CRC). Methods The levels of serum tumor markers (CEA, CA24-2 and CA19-9) and clinical characteristics in patients with colorectal cancer were evaluated. In addition, KRAS/NRAS/PIK3CA/BRAF mutations were detected in some patients with colorectal cancer. Results A total of 2,281 patients were recruited in the study, included 1,578 colorectal cancer patients and 703 controls. The levels of CEA, CA24-2 and CA19-9 in colorectal cancer group was significantly higher than control group. The sensitivities of three individual markers were lower than 30%, which individual sensitivity of the tumor markers sorted in descending order was CEA>CA19-9>CA24-2. The specificities of three individual markers were more than 92%, and the specificity sorted in descending order was CA24-2>CA19-9>CEA. The combination of CEA+CA19-9+CA24-2 ranked the highest in sensitivity index and specificity index for colorectal cancer diagnosis. The prediction equation excluding the risk of colorectal cancer was. Probability (normal) = Exp (-5.47 - 0.28CEA - 0.11 CA242 + 0.001 CA199)/ (1+ Exp (-5.47 - 0.28CEA - 0.11 CA242 + 0.001 CA199)). There were no significant differences in age, gender, histology type, differentiation, depth of invasion and TNM stage between mutations in KRAS/NRAS, BRAF and PIK3CA genes or not, respectively. Conclusions Serum CEA, CA24-2, and CA19-9 are valuable noninvasive indicators for prediction the risk of colorectal cancer. We need to look for other, more sensitive tumor markers.

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“…Cancer antigens CEA and CA19–9 are the two most common colon cancer markers [ 29 ], used not only for preoperative assessment of extent and outcome of the disease, but also for monitoring recurrence after surgery. Increased serum concentrations of CEA and CA19–9 are associated with advanced invasion, lymph node metastasis, and short survival [ 30 , 31 ].…”

Section: Discussionmentioning

confidence: 99%

Combination of serum lipids and cancer antigens as a novel marker for colon cancer diagnosis

Qian²,

et al. 2018

Lipids Health Dis

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BackgroundColon cancer is a malignancy of the large intestine with high mortality and economic burden. Recent studies reveal a new relationship between blood lipids and the risk of cancer. The presents study aims to investigate the combination of serum lipids with cancer antigens as a novel diagnostic marker for colon cancer.MethodsTwo hundred of colon cancer patients or healthy subjects were recruited. Serum lipids and cancer antigens such as total cholesterol (TC), high-density lipoprotein (HDL), carcinoembryonic antigen (CEA) and carbohydrate antigen 19–9 (CA19–9) were measured.ResultsThere were significantly lower level of serum TC or HDL, and significantly higher level of serum CEA or CA19–9 in patients than in healthy subjects. Serum TC or HDL in patients with advanced colon cancer was significantly lower than the ones with early stage disease. The level of serum TC or HDL in patients after surgical removal of colon cancer was significantly higher compared to the ones before surgery, but serum CEA or CA19–9 after surgery was significantly reduced in comparison with the ones before surgery. Combined TC, HDL, CEA and CA19–9 as a diagnostic marker for colon cancer had the highest positive predictive rate in comparison with individual, two or three of the parameters.ConclusionsThe combination of serum TC, HDL, CEA and CA19–9 can be used as an effective marker for colon cancer, and offers a novel strategy for clinical diagnosis and monitoring the disease.

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Clinical value of a diagnostic score for colon cancer based on serum CEA, CA19-9, cytokeratin-1 and mucin-1

Abstract: A colon score derived from serum CEA, CA19-9, CK1 and MUC1 is a potential valuable non-invasive index that could be used for detection and screening early stage colon cancer patients.

Cited by 26 publications

References 27 publications

Clinical Diagnostic Value for Colorectal cancer Based on Serum CEA, CA24-2 and CA19-9

Clinical Diagnostic Value for Colorectal cancer Based on Serum CEA, CA24-2 and CA19-9

Clinical Diagnostic Value for Colorectal Cancer Based on Serum CEA, CA24-2 and CA19-9

Combination of serum lipids and cancer antigens as a novel marker for colon cancer diagnosis

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