Clinical validation of time reduction strategy in continuous step-and-shoot mode during SPECT acquisition

Picone, Valentin; Makris, Nikolaos; Boutevin, Fanny; Roy, Sarah Le; Playe, Margot; Soussan, Michaël

doi:10.1186/s40658-021-00354-x

Cited by 15 publications

(8 citation statements)

References 15 publications

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“…SwiftScan SPECT and SSM were similar in quantitative value comparison regardless of scan time. A previous study has reported that SwiftScan SPECT does not affect quantification in clinical bone quantitative SPECT, even with 25% less acquisition time than SSM [ 20 ]. These results support the use of SwiftScan SPECT to reduce examination time or injection radioactivity.…”

Section: Discussionmentioning

confidence: 99%

“…Several clinical studies have shown the potential of SwiftScan SPECT in reducing acquisition time. Bailly et al [ 16 ] and Picone et al [ 20 ] showed the potential for a 25% reduction in acquisition time without degradation of image quality and quantitation in dopamine transporter and bone, respectively. However, to our knowledge, no studies so far have investigated the effect of acquisition time in SwiftScan using a phantom in quantitative bone SPECT.…”

Section: Introductionmentioning

confidence: 99%

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Verification of the effect of acquisition time for SwiftScan on quantitative bone single-photon emission computed tomography using an anthropomorphic phantom

et al. 2022

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Background SwiftScan single-photon emission computed tomography (SPECT) is a recently released scanning technique with data acquired when the detector is stationary and when it moves from one view to the next. The influence of scan time for using SwiftScan on quantitative bone SPECT remains unclear. This study aimed to clarify the effect of the scan time for SwiftScan SPECT on the image quality and quantification of bone SPECT compared to step and shoot mode (SSM) using 99mTc-filled anthropomorphic phantom (SIM2 bone phantom). Materials and methods Phantom SPECT/computed tomography (CT) images were acquired using Discovery NM/CT 860 (GE Healthcare) with a low-energy high-resolution sensitivity collimator. We used the fixed parameters (subsets 10 and iterations 5) for reconstruction. The coefficient of variation (CV), contrast-to-noise ratio (CNR), full width at half maximum (FWHM), and quantitative value of SwiftScan SPECT and SSM were compared at various acquisition times (5, 7, 17, and 32 min). Results In the short-time scan (< 7 min), the CV and CNR of SwiftScan SPECT were better than those of SSM, whereas in the longtime scan (> 17 min), the CV and CNR of SwiftScan SPECT were similar to those of SSM. The FWHMs for SwiftScan SPECT (13.6–14.8 mm) and SSM (13.5–14.4 mm) were similar. The mean absolute errors of quantitative values at 5, 7, 17, and 32 min were 38.8, 38.4, 48.8, and 48.1, respectively, for SwiftScan SPECT and 41.8, 40.8%, 47.2, and 49.8, respectively, for SSM. Conclusions SwiftScan on quantitative bone SPECT provides improved image quality in the short-time scan with quantification similar to or better than SSM. Therefore, in clinical settings, using SwiftScan SPECT instead of the SSM scan protocol in the short-time scan might provide higher-quality diagnostic images than SSM. Our results could provide vital information on the use of SwiftScan SPECT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Verification of the effect of acquisition time for SwiftScan on quantitative bone single-photon emission computed tomography using an anthropomorphic phantom

et al. 2022

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“…Basically, the importance of "continuous image acquisition" is to eliminate the dead time between the angles at consecutive detector positions by not acquiring the data which results in loss of significant number of photons. In fact a tomographic step-and-shoot continuous mode acquisition, so-called SwiftScan, has been investigated to determine whether this can be used in clinical practice as a part of time reduction strategy, while preserving image quality and accuracy (14)(15)(16). The continuous image acquisition for dynamic scan using conventional two-head gamma cameras provides an additional attribute to MPI, which to our knowledge, has not been initiated yet.…”

Section: Introductionmentioning

confidence: 99%

Monte Carlo Simulation and Reconstruction: Assessment of Myocardial Perfusion Imaging of Tracer Dynamics With Cardiac Motion Due to Deformation and Respiration Using Gamma Camera With Continuous Acquisition

Huh

Shrestha

Gullberg

et al. 2022

Front. Cardiovasc. Med.

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PurposeMyocardial perfusion imaging (MPI) with single photon emission computed tomography (SPECT) is routinely used for stress testing in nuclear medicine. Recently, our group extended its potential going from 3D visual qualitative image analysis to 4D spatiotemporal reconstruction of dynamically acquired data to capture the time variation of the radiotracer concentration and the estimated myocardial blood flow (MBF) and coronary flow reserve (CFR). However, the quality of reconstructed image is compromised due to cardiac deformation and respiration. The work presented here develops an algorithm that reconstructs the dynamic sequence of separate respiratory and cardiac phases and evaluates the algorithm with data simulated with a Monte Carlo simulation for the continuous image acquisition and processing with a slowly rotating SPECT camera.MethodsA clinically realistic Monte Carlo (MC) simulation is developed using the 4D Extended Cardiac Torso (XCAT) digital phantom with respiratory and cardiac motion to model continuous data acquisition of dynamic cardiac SPECT with slowly rotating gamma cameras by incorporating deformation and displacement of the myocardium due to cardiac and respiratory motion. We extended our previously developed 4D maximum-likelihood expectation-maximization (MLEM) reconstruction algorithm for a data set binned from a continuous list mode (LM) simulation with cardiac and respiratory information. Our spatiotemporal image reconstruction uses splines to explicitly model the temporal change of the tracer for each cardiac and respiratory gate that delineates the myocardial spatial position as the tracer washes in and out. Unlike in a fully list-mode data acquisition and reconstruction the accumulated photons are binned over a specific but very short time interval corresponding to each cardiac and respiratory gate. Reconstruction results are presented showing the dynamics of the tracer in the myocardium as it continuously deforms. These results are then compared with the conventional 4D spatiotemporal reconstruction method that models only the temporal changes of the tracer activity. Mean Stabilized Activity (MSA), signal to noise ratio (SNR) and Bias for the myocardium activities for three different target-to-background ratios (TBRs) are evaluated. Dynamic quantitative indices such as wash-in (K1) and wash-out (k2) rates at each gate were also estimated.ResultsThe MSA and SNR are higher with higher TBRs while biases were improved with higher TBRs to less than 10%. The correlation between exhalation-inhalation sequence with the ground truth during respiratory cycle was excellent. Our reconstruction method showed better resolved myocardial walls during diastole to systole as compared to the ungated 4D image. Estimated values of K1 and k2 were also consistent with the ground truth.ConclusionThe continuous image acquisition for dynamic scan using conventional two-head gamma cameras can provide valuable information for MPI. Our study demonstrated the viability of using a continuous image acquisition method on a widely used clinical two-head SPECT system. Our reconstruction method showed better resolved myocardial walls during diastole to systole as compared to the ungated 4D image. Precise implementation of reconstruction algorithms, better segmentation techniques by generating images of different tissue types and background activity would improve the feasibility of the method in real clinical environment.

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“…Several researchers have shown the potential for reduced acquisition time with SwiftScan SPECT in a clinical study. Bailly et al [16] and Picone et al [19] showed the potential for a 25% reduction in acquisition time without degradation of image quality and quantitation in bone and lung and dopamine transporter, respectively. However, there was no investigation of the effect of acquisition time in SwiftScan using a phantom in quantitative bone SPECT.…”

Section: Introductionmentioning

confidence: 99%

Verification of Effect of Acquisition Time for SwiftScan on Quantitative Bone Single-Photon Emission Computed Tomography Using an Anthropomorphic Phantom

Shiiba

Sekikawa

Tateoka

et al. 2022

Preprint

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Background: SwiftScan (GE Healthcare) is a recently developed scanning technique with data acquisition during detector static and rotation. The influence of image quality using SwiftScan on quantitative bone single-photon emission computed tomography (SPECT) remains unclear. This study clarifies the effect of the acquisition time for SwiftScan on the image quality and quantification of bone SPECT compared to step and shoot mode (SSM) using 99mTc-filled anthropomorphic phantom (SIM2 bone phantom).Results: The coefficient of variance (CV), contrast-to-noise ratio (CNR), full width at half maximum (FWHM), and recovery coefficient (RC) of SwiftScan and SSM were recorded at various overall acquisition times (5, 7, 17, and 32 min) when the fixed reconstruction parameters (subsets 10 and iterations 5) were compared. The CV of SSM was higher than that of SwiftScan in short-time acquisition (less than 7 min), whereas the CV of SSM and SwiftScan are equivocal in long-time acquisition (more than 17 min). The CNR of SwiftScan was higher than that of SSM in short-time acquisition, whereas the CNR of SSM was equivocal or higher than that of SwiftScan in long-time acquisition. The FWHM of SSM (15.2–16.5 mm) and SwiftScan (15.4–15.9 mm) was almost constant when the acquisition time was 7 min or longer. However, SwiftScan (22.6 mm) and SSM (18.6 mm) showed high FWHM values at 5 min acquisition, deviating from the actual size (10 mm). For the RC of SwiftScan and SSM, was no evident difference between them was observed.Conclusions: SwiftScan on quantitative bone SPECT provides improved CV and CNR in short-time acquisition (less than 7 min) with quantitativeness similar to SSM. Therefore, using SwiftScan in clinical settings instead of the SSM scan protocol in short-time acquisition (less than 7 min) might provide higher quality diagnostic images than SSM. Our results would provide important information on the use of SwiftScan.

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Clinical validation of time reduction strategy in continuous step-and-shoot mode during SPECT acquisition

Cited by 15 publications

References 15 publications

Verification of the effect of acquisition time for SwiftScan on quantitative bone single-photon emission computed tomography using an anthropomorphic phantom

Verification of the effect of acquisition time for SwiftScan on quantitative bone single-photon emission computed tomography using an anthropomorphic phantom

Monte Carlo Simulation and Reconstruction: Assessment of Myocardial Perfusion Imaging of Tracer Dynamics With Cardiac Motion Due to Deformation and Respiration Using Gamma Camera With Continuous Acquisition

Verification of Effect of Acquisition Time for SwiftScan on Quantitative Bone Single-Photon Emission Computed Tomography Using an Anthropomorphic Phantom

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