Clinical validation of pharmacokinetic/pharmacodynamic models for propofol infusion. Response to Br J Anaesth 2021: 126: e172-4

Vellinga, Remco; Hannivoort, Laura N.; Koomen, Jeroen V.; Colin, Pieter; Absalom, Anthony; Struys, Michel; Eleveld, Douglas J.

doi:10.1016/j.bja.2021.03.021

Cited by 2 publications

(2 citation statements)

References 10 publications

(16 reference statements)

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“…Some authors have suggested that an optimal approach would be required to develop different models for various clinical situations and apply them as appropriate [16]. The drawback of this approach is that it requires substantial scientific knowledge from users and some models may simply not be available in a clinical setting for the diversity of cases [17].…”

Section: When Is a Model Appropriate?mentioning

confidence: 99%

General purpose models for intravenous anesthetics, the next generation for target-controlled infusion and total intravenous anesthesia?

Vellinga,

Eleveld,

Struys

et al. 2023

Current Opinion in Anaesthesiology

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Purpose of review There are various pharmacokinetic-dynamic models available, which describe the time course of drug concentration and effect and which can be incorporated into target-controlled infusion (TCI) systems. For anesthesia and sedation, most of these models are derived from narrow patient populations, which restricts applicability for the overall population, including (small) children, elderly, and obese patients. This forces clinicians to select specific models for specific populations. Recent findings Recently, general purpose models have been developed for propofol and remifentanil using data from multiple studies and broad, diverse patient groups. General-purpose models might reduce the risks associated with extrapolation, incorrect usage, and unfamiliarity with a specific TCI-model, as they offer less restrictive boundaries (i.e., the patient “doesn’t fit in the selected model”) compared with the earlier, simpler models. Extrapolation of a model can lead to delayed recovery or inadequate anesthesia. If multiple models for the same drug are implemented in the pump, it is possible to select the wrong model for that specific case; this can be overcome with one general purpose model implemented in the pump. Summary This article examines the usability of these general-purpose models in relation to the more traditional models.

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Section: When Is a Model Appropriate?mentioning

confidence: 99%

General purpose models for intravenous anesthetics, the next generation for target-controlled infusion and total intravenous anesthesia?

Vellinga,

Eleveld,

Struys

et al. 2023

Current Opinion in Anaesthesiology

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show abstract

“…Recently, the first general purpose model, the Eleveld-model, for propofol became available and was validated in clinical practice [ 69 ]. The Eleveld PK-PD model [ 70 ] is unique in that it can be used for target-controlled infusions in children, adults, older subjects and the obese [ 69 , 71 ].…”

Section: New Pk-pd Models For Existing Anaesthetic Drugs For Tci Appl...mentioning

confidence: 99%

What’s New in Intravenous Anaesthesia? New Hypnotics, New Models and New Applications

Vellinga

Valk

Absalom

et al. 2022

JCM

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New anaesthetic drugs and new methods to administer anaesthetic drugs are continually becoming available, and the development of new PK-PD models furthers the possibilities of using arget controlled infusion (TCI) for anaesthesia. Additionally, new applications of existing anaesthetic drugs are being investigated. This review describes the current situation of anaesthetic drug development and methods of administration, and what can be expected in the near future.

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Clinical validation of pharmacokinetic/pharmacodynamic models for propofol infusion. Response to Br J Anaesth 2021: 126: e172-4

Cited by 2 publications

References 10 publications

General purpose models for intravenous anesthetics, the next generation for target-controlled infusion and total intravenous anesthesia?

General purpose models for intravenous anesthetics, the next generation for target-controlled infusion and total intravenous anesthesia?

What’s New in Intravenous Anaesthesia? New Hypnotics, New Models and New Applications

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