Clinical validation of high-resolution image reconstruction algorithms in brain 18F-FDG-PET

Nagaki, Akio; Onoguchi, Masahisa; Matsutomo, Norikazu

doi:10.1097/mnm.0000000000000187

Cited by 17 publications

(6 citation statements)

References 22 publications

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“…Previous studies have clarified that the combined use of PSF and TOF leads to greater improvements in SNR, spatial resolution, and uniformity than using PSF or TOF alone [21]. Similar results have been observed in brain PET imaging studies [22,23]. PSF + TOF has also been observed to increase SUVs for lesions, exerting a particularly large effect on small structures [24,25].…”

Section: Shao Et Al Investigated the Effects Of Psf Correction On Bra...supporting

confidence: 64%

Effects of point spread function correction and time-of-flight on visual contrast level and pixel values in brain PET images

Kamikawa

Yoshida

Kawahara

2023

Nuclear Medicine Communications

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Objectives Point spread function (PSF) correction and time-of-flight (TOF) can improve the quality of PET images. None have directly assessed the visual effects of these methods in brain PET images and evaluated the image quality from these methods based on the relationship between the number of updates and noise level. The present study aimed to clarify the effects of PSF and TOF on the visual contrast level and pixel values of brain PET images using an experimental phantom. Materials and methodsThe visual contrast level was evaluated based on the sum of edge strengths. In addition, the effects of PSF, TOF, and a combination of them on pixel values were evaluated after anatomical standardization of brain images, in which the whole brain was divided into 18 segments. These were evaluated using images reconstructed with the number of updates set to achieve the same noise level. ResultsCombined application of the point spread function and TOF resulted in the greatest increase in the sum of edge strengths (32%), followed by PSF (21%) and TOF (6%). The maximum increase in pixel values occurred in the thalamic area (17%). ConclusionAlthough PSF and TOF can increase the visual contrast level by increasing the sum of edge strengths, they may affect the results of software-based analysis using pixel values. Nonetheless, using these methods may improve the ability to visualize areas of hypoaccumulation, such as epileptic foci. Nucl Med Commun 44: 442-456

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Section: Shao Et Al Investigated the Effects Of Psf Correction On Bra...supporting

confidence: 64%

Effects of point spread function correction and time-of-flight on visual contrast level and pixel values in brain PET images

Kamikawa

Yoshida

Kawahara

2023

Nuclear Medicine Communications

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“…under pharmacological or non-pharmacological experimental challenges, are expected to advance molecular characterization of neurodegenerative disorders and CVD in clinical human neurosciences. Finally, improvements in PET imaging temporal resolution have opened a field for integrating time-of-flight 33 , 34 information into the reconstruction process, leading to the high resolution of today's PET/CT systems, again, improving imaging capabilities, potentially reducing acquisition times and improving the specificity of the imaging set-up.…”

Section: Resultsmentioning

confidence: 99%

A panel of clinical and neuropathological features of cerebrovascular disease through the novel neuroimaging methods

Alves

Carvalho

Sudo

et al. 2017

Dement. neuropsychol.

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ABSTRACT.The last decade has witnessed substantial progress in acquiring diagnostic biomarkers for the diagnostic workup of cerebrovascular disease (CVD). Advanced neuroimaging methods not only provide a strategic contribution for the differential diagnosis of vascular dementia (VaD) and vascular cognitive impairment (VCI), but also help elucidate the pathophysiological mechanisms ultimately leading to small vessel disease (SVD) throughout its course.Objective:In this review, the novel imaging methods, both structural and metabolic, were summarized and their impact on the diagnostic workup of age-related CVD was analysed. Methods: An electronic search between January 2010 and 2017 was carried out on PubMed/MEDLINE, Institute for Scientific Information Web of Knowledge and EMBASE.Results:The use of full functional multimodality in simultaneous Magnetic Resonance (MR)/Positron emission tomography (PET) may potentially improve the clinical characterization of VCI-VaD; for structural imaging, MRI at 3.0 T enables higher-resolution scanning with greater imaging matrices, thinner slices and more detail on the anatomical structure of vascular lesions.Conclusion:Although the importance of most of these techniques in the clinical setting has yet to be recognized, there is great expectancy in achieving earlier and more refined therapeutic interventions for the effective management of VCI-VaD.

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“…However, that study did not find a benefit of TOF with an SiPM-PET system for brain PET. Nagaki et al found that contrast in [ 18 F]FDG brain imaging was not improved using the PMT-PET system at a timing resolution of 555 ps [30]. The sensitivity gain using TOF was increased as a function of increasing the object size [31].…”

Section: Discussionmentioning

confidence: 99%

Direct comparison of brain [18F]FDG images acquired by SiPM-based and PMT-based PET/CT: phantom and clinical studies

et al. 2020

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Background Silicon photomultiplier-positron emission tomography (SiPM-PET) has better sensitivity, spatial resolution, and timing resolution than photomultiplier tube (PMT)-PET. The present study aimed to clarify the advantages of SiPM-PET in 18F-fluoro-2-deoxy-D-glucose ([18F]FDG) brain imaging in a head-to-head comparison with PMT-PET in phantom and clinical studies. Methods Contrast was calculated from images acquired from a Hoffman 3D brain phantom, and image noise and uniformity were calculated from images acquired from a pool phantom using SiPM- and PMT-PET. Sequential PMT-PET and SiPM-PET [18F]FDG images were acquired over a period of 10 min from 22 controls and 10 patients. All images were separately normalized to a standard [18F]FDG PET template, then the mean standardized uptake values (SUVmean) and Z-score were calculated using MIMneuro and CortexID Suite, respectively. Results Image contrast, image noise, and uniformity in SiPM-PET changed 19.2, 3.5, and − 40.0% from PMT-PET, respectively. These physical indices of both PET scanners satisfied the criteria for acceptable image quality published by the Japanese Society of Nuclear Medicine of contrast > 55%, CV ≤ 15%, and SD ≤ 0.0249, respectively. Contrast was 70.0% for SiPM-PET without TOF and 59.5% for PMT-PET without TOF. The TOF improved contrast by 3.5% in SiPM-PET. The SUVmean using SiPM-PET was significantly higher than PMT-PET and did not correlate with a time delay. Z-scores were also significantly higher in images acquired from SiPM-PET (except for the bilateral posterior cingulate) than PMT-PET because the peak signal that was extracted by the calculation of Z-score in CortexID Suite was increased. The hypometabolic area in statistical maps was reduced and localized using SiPM-PET. The trend was independent of whether the images were derived from controls or patients. Conclusions The improved spatial resolution and sensitivity of SiPM-PET contributed to better image contrast and uniformity in brain [18F]FDG images. The SiPM-PET offers better quality and more accurate quantitation of brain PET images. The SUVmean and Z-scores were higher in SiPM-PET than PMT-PET due to improved PVE. [18F]FDG images acquired using SiPM-PET will help to improve diagnostic outcomes based on statistical image analysis because SiPM-PET would localize the distribution of glucose metabolism on Z-score maps.

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Clinical validation of high-resolution image reconstruction algorithms in brain 18F-FDG-PET

Abstract: We have demonstrated that a high-resolution image reconstruction algorithm for brain F-FDG-PET is promising without the use of a GF because of high true coincidence counts and that combined with PSF and TOF is optimal for obtaining a better SNR of the image.

Cited by 17 publications

References 22 publications

Effects of point spread function correction and time-of-flight on visual contrast level and pixel values in brain PET images

Effects of point spread function correction and time-of-flight on visual contrast level and pixel values in brain PET images

A panel of clinical and neuropathological features of cerebrovascular disease through the novel neuroimaging methods

Direct comparison of brain [18F]FDG images acquired by SiPM-based and PMT-based PET/CT: phantom and clinical studies

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