Clinical Validation of a Point-of-Care Multiplexed
            <i>In Vitro</i>
            Immunoassay Using Monoclonal Antibodies (the MSD Influenza Test) in Four Hospitals in Vietnam

Doorn, H. Rogier van; Kính, Nguyễn Văn; Tuan, Ha Manh; Tuấn, Trần Anh; Minh, Ngo Ngọc Quang; Bryant, Juliet E.; Hang, Vu Thi Ty; Uyen, Le thi Tham; Thinh, Le Quoc; Ánh, Trần Thị Ngọc; Lan, Nguyen Phu Huong; Trung, Nguyen Vu; Taylor, Walter; Merson, Laura; Wertheim, Heiman; Farrar, Jeremy; Wolbers, Marcel; Châu, Nguyễn Văn Vĩnh; Jong, Menno D. de

doi:10.1128/jcm.00085-12

Cited by 12 publications

(8 citation statements)

References 15 publications

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“…Higher sensitivity among younger children is likely due to higher virus shedding in this age group (6,11,16). Most studies have failed to report the performance of RIDTs exclusively among the elderly or grouped them together with other adults (4,12). We found a higher sensitivity of RIDTs for influenza virus A in the elderly than among adults 20 to 64 years of age, which may be related to having more severe disease, prolonged shedding, and high viral loads, which leads to better sensitivity (11,15,17).…”

Section: Discussionmentioning

confidence: 99%

“…The sensitivity and specificity of RIDTs vary with the individual tests, the influenza virus type and subtype, the body site from which the specimen was collected (e.g., nasopharyngeal versus throat swab), the time to specimen collection, and patient age (1)(2)(3)(4). In addition, their positive predictive values (PPVs) and negative predictive values (NPVs) are influenced by the prevalence of influenza in the population tested (5).…”

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confidence: 99%

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Performance of Rapid Influenza Diagnostic Testing in Outbreak Settings

et al. 2014

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Performance of Rapid Influenza Diagnostic Testing in Outbreak Settings

et al. 2014

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“…Reports from previous studies attest that these RATs have good specificity and moderate clinical sensitivity for use in the detection of seasonal influenza infections. 7,8 However, the performance and utility of RAT under field conditions in resource-limited countries are not well described. We evaluated the sensitivity and specificity of the SD Bioline RAT by using the rRT-PCR as the standard reference.…”

Section: Introductionmentioning

confidence: 99%

Evaluating the performance of a rapid antigen test for the detection of influenza virus in clinical specimens from children in Cameroon

Kenmoe

Tchendjou

Tetang

et al. 2013

Influenza Resp Viruses

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The performance of SD Bioline rapid antigen test (RAT) was evaluated using real-time reverse transcription polymerase chain reaction (rRT-PCR) as gold standard. A total of 718 nasal swabs, including 102 rRT-PCR positive and 616 rRT-PCR negative swabs, were tested. RAT demonstrates a sensitivity of 29·4% with a specificity of 100%. The positivity rate of RAT was highly associated with lower cycle threshold (Ct) values (P < 0·0001). The excellent specificity of the RAT allowed for the rapid identification of influenza cases. However, negative results should be verified by rRT-PCR test because of limitations observed in sensitivity.

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“…Commercially available RIDTs are widely used in clinical practice as pointof-care tests because they are simple to use and provide results within 15 to 30 min (12,13). However, their sensitivities vary widely depending on the manufacturer and can be as low as 10%, with specificities ranging from 90 to 100% (14).…”

mentioning

confidence: 99%