Clinical utilization of bacteriophages: a new perspective to combat the antimicrobial resistance in Brazil

Martins, Willames M. B. S.; Toleman, Mark A.; Gales, Ana Cristina

doi:10.1016/j.bjid.2020.04.010

Cited by 9 publications

(15 citation statements)

References 51 publications

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“…Commensal bacteria in human microbiota can stop the invading pathogens [ 19 ]. Bacteriophages can target specific bacterial strains, including drug-resistant pathogens [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Sequence Permutation Generates Peptides with Different Antimicrobial and Antibiofilm Activities

et al. 2020

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Antibiotic resistance poses a threat to our society, and 10 million people could die by 2050. To design potent antimicrobials, we made use of the antimicrobial peptide database (APD). Using the database filtering technology, we identified a useful template and converted it into an effective peptide WW291 against methicillin-resistant Staphylococcus aureus (MRSA). Here, we compared the antibacterial activity and cytotoxicity of a family of peptides obtained from sequence permutation of WW291. The resulting eight WW peptides (WW291-WW298) gained different activities against a panel of bacteria. While WW295 inhibited the growth of Escherichia coli, WW298 was highly active against S. aureus USA300 LAC. Consistently with this, WW298 was more effective in permeating or depolarizing the S. aureus membranes, whereas WW295 potently permeated the E. coli membranes. In addition, WW298, but not WW295, inhibited the MRSA attachment and could disrupt its preformed biofilms more effectively than daptomycin. WW298 also protected wax moths Galleria mellonella from MRSA infection causing death. Thus, sequence permutation provides one useful avenue to generating antimicrobial peptides with varying activity spectra. Taken together with amino acid composition modulation, these methods may lead to narrow-spectrum peptides that are more promising to selectively eliminate invading pathogens without damaging commensal microbiota.

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“…Commensal bacteria in human microbiota can stop the invading pathogens [ 19 ]. Bacteriophages can target specific bacterial strains, including drug-resistant pathogens [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Sequence Permutation Generates Peptides with Different Antimicrobial and Antibiofilm Activities

et al. 2020

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“…Bacteriophages (phages) are ubiquitous viruses which cause no harm to human or animal cells but are capable to specifically infect, replicate, and kill bacteria [40,41]. Bacteriophages have been described for delivering successfully antimicrobial agents into bacteria, which consist in a potential alternative for the treatment of infectious diseases [42,43] caused by bacteria.…”

Section: Bacteriophages and Pdtmentioning

confidence: 99%

Light and Phages on Tackle of Infectious Diseases

Cruz¹,

Bogas²,

Sousa³

2021

Bacteriophages in Therapeutics

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There has been an important increase in the emergence of resistance in microbial population worldwide. This trajectory needs, necessarily new approaches to treat infectious diseases. The ability to detect and prevent the evolutionary trajectories of microbial resistance would be of value. Photodynamic inactivation (PDI) represents an efficient alternative treatment for diseases caused by viruses, which can cause infections well documented in various mammals. PDI can kill cells after exposure with the appropriate photosensitizer (PS), light of adequate wavelength combined with the presence of oxygen, without inducing resistance. Cytotoxic reactive species formed interaction with vital biomolecules leading to irreversible microbial inactivation. Bacteriophages can act on delivering antimicrobial agents into bacteria, which consist in a likely instrument for the treatment of infectious diseases. Non-enveloped bacteriophages are more difficult to tolerate photoinactivation than enveloped phages, which makes them an important model tool to evaluate the efficiency of PDI therapy against viruses that cause diseases in humans. Combination of photosensitizers and bacteriophage therapy can be employed to eradicate biofilms, contributing to control of infections also caused by drug-resistant bacteria.

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“…The general lack of new antibiotics, the costs and difficulties associated with their discovery and licensing has led to a renaissance in bacteriophage therapy [34]. Bacteriophages are viruses that kill bacteria but are harmless to humans and animals and are ubiquitous in nature [35]. They were first used to treat animal and human diseases in the 1920's [35,36].…”

Section: Am J Biomed Sci and Resmentioning

confidence: 99%

“…Bacteriophages are viruses that kill bacteria but are harmless to humans and animals and are ubiquitous in nature [35]. They were first used to treat animal and human diseases in the 1920's [35,36]. Though bacteriophage therapy has been used successfully to treat many different bacterial infections in former Soviet block countries for nearly a century.…”

Section: Am J Biomed Sci and Resmentioning

confidence: 99%

“…This was associated with their broad spectrum of activity against numerous bacterial pathogens in comparison to the narrow spectrum of bacteriophage. Individual bacteriophages kill individual species of bacteria and normally a limited number of strains of an individual species though broader spectrum bacteriophages have also been identified [35]. Their narrow spectrum made them unreliable without prior testing of bacterial susceptibility and more suited to costly personalized medicine.…”

Section: Am J Biomed Sci and Resmentioning

confidence: 99%

See 1 more Smart Citation

Engineering the Human Microbiome, A Natural Double-Barreled Approach Towards Solving both our Current Antibiotic Resistance and Sepsis Problems

Toleman¹

2020

AJBSR

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Clinical utilization of bacteriophages: a new perspective to combat the antimicrobial resistance in Brazil

Cited by 9 publications

References 51 publications

Sequence Permutation Generates Peptides with Different Antimicrobial and Antibiofilm Activities

Sequence Permutation Generates Peptides with Different Antimicrobial and Antibiofilm Activities

Light and Phages on Tackle of Infectious Diseases

Engineering the Human Microbiome, A Natural Double-Barreled Approach Towards Solving both our Current Antibiotic Resistance and Sepsis Problems

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