Clinical Utility of the Anti‐CCP Assay: Experiences with 700 Patients

Sauerland, Ulrich; Becker, H; Seidel, Matthias; Schotte, Heiko; Willeke, P.; Schorat, Annette; Schlüter, B.; Domschke, Wolfram; Gaubitz, M.

doi:10.1196/annals.1313.033

Cited by 60 publications

(44 citation statements)

References 8 publications

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“…These antibodies are thought to be triggered by the genes that increase susceptibility to RA as well as by many environmental agents. [3] The anti-cyclic citrullinated peptide (anti-CCP) has a comparable sensitivity to RF (50-75%) with a higher specificity (90-95%) [3,5] and is the new candidate for the crown of RF. Along with anti-CCP, there has been interest in another new marker, anti-mutated citrullinated vimentin (anti-MCV).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Autoantibodies Against Citrullinated Peptide Antigens in Rheumatoid Arthritis: Comparison of Different Commercial Kits

et al. 2011

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Amaç: Bu çalışmada romatoid faktörün (RF), anti-siklik sitrülin peptit (anti-CCP) antikorunun ve anti-mutat sitrülin vimentin (anti-MCV) antikorunun iki farklı ticari kitinin, ticari kitlerin performansları arasında önemli farklılıklar bulunabileceğini de göz önünde bulundurarak, romatoid artritteki (RA) tanısal değerleri test edildi. Bulgular:Otoantikorların tanısal duyarlılık ve özgüllüğünü belirlemek için yapılan alıcı işletim karakteristiği (ROC) eğrisi analizinde en yüksek eğri altında kalan alan değeri anti-CCP-2'ye aitti. Duyarlılık ve özgüllük RF için %88 ve %90, anti-CCP-2 için %84 ve %100, anti-MCV-548 için %80 ve %90 ve anti-MCV-248 için %84 ve %100 idi. DAS-28 ile anti-CCP-2 (r= 0.623), anti-MCV-548 (r= 0.481) ve anti-MCV-248 (r= 0.408) arasında zayıf bir korelasyon vardı. Ekstraartiküler tutulumu olan ve olmayan hastaların ve DAS-28'e göre düşük veya orta şiddette hastalık aktivitesi olan hastaların RF, anti-CCP-2, anti-MCV-548 ve anti-MCV-248 değerleri arasında istatistiksel olarak anlamlı bir fark yoktu.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Value of Autoantibodies Against Citrullinated Peptide Antigens in Rheumatoid Arthritis: Comparison of Different Commercial Kits

et al. 2011

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“…The specificity of anti-CCP antibodies for RA has been established in several studies including other autoimmune and infectious diseases (16,(18)(19)(20)(21)(22)(23). This is the first study designed to evaluate anti-CCP antibodies in a large number of leprosy patients either with (N = 76) or without (N = 82) articular involvement.…”

Section: Sle Ribeiro Et Almentioning

confidence: 99%

“…Anti-CCP antibodies have been evaluated in a large number of patients with different autoimmune (16,(18)(19)(20)(21) and infectious diseases (16,(21)(22)(23)(24). More recently, a high frequency (32%) of anti-CCP antibodies was reported in patients with active lung tuberculosis (24) and another study showed a low frequency of anti-CCP among patients with leprosy, a disease caused by another mycobacterium (25).…”

Section: Introductionmentioning

confidence: 99%

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Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in leprosy patients with articular involvement

Ribeiro

Pereira

Silva

et al. 2008

Braz J Med Biol Res

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The objective of the present research was to evaluate the usefulness of anti-cyclic citrullinated peptide (anti-CCP) antibodies and the IgM rheumatoid factor (IgM RF) test for the differential diagnosis of leprosy with articular involvement and rheumatoid arthritis (RA). Anti-CCP antibodies and IgM RF were measured in the sera of 158 leprosy patients (76 with and 82 without articular involvement), 69 RA patients and 89 healthy controls. Leprosy diagnosis was performed according to Ridley and Jopling classification criteria and clinical and demographic characteristics of leprosy patients were collected by a standard questionnaire. Leprosy patients with any concomitant rheumatic disease were excluded. Serum samples were obtained from all participants and frozen at -20°C. Measurement of anti-CCP antibodies and IgM RF were performed by ELISA, using a commercial second-generation kit, and the latex agglutination test, respectively. Anti-CCP antibodies and IgM RF were detected in low frequencies (2.6 and 1.3%, respectively) in leprosy patients and were not associated with articular involvement. Among healthy individuals both anti-CCP antibodies and IgM RF were each detected in 3.4% of the subjects. In contrast, in the RA group, anti-CCP antibodies were present in 81.2% and IgM RF in 62.3%. In the present study, both anti-CCP antibodies and IgM RF showed good positive predictive value for RA, helping to discriminate between RA and leprosy patients with articular involvement. However, anti-CCP antibodies were more specific for RA diagnosis in the population under study.

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“…Synthetic CCP variants react with anti-ilaggrin autoantibodies and serve as substrate for detecting anti-CCP antibodies serologically 6 . The sensitivity of anti-CCP is about 74% and the speci icity is 96% to 98%, as compared to RF whose sensitivity and speci icity are 69.7% and 81%, respectively 7 . Hence, anti-CCP assay is a more speci ic and powerful serologic marker for diagnosing RA.…”

Section: Discussionmentioning

confidence: 99%

Monoarticular rheumatoid arthritis of the wrist: a rare entity

Douraiswami¹,

Thanigai²

2013

OA Case Reports

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Introduction Monoarticular presentation of rheumatoid arthritis is infrequent and it usually occurs in the hip and knee joints. We report such a case in a 70-year-old male with monoarticular rheumatoid arthritis of the left wrist. Case report A 70-year-old male patient presented with pain and restriction of movements of his left wrist. Radiographs showed lytic lesions in distal radius and carpal bones, concentric reduction of wrist joint space and periarticular osteoporosis. Erythrocyte sedimentation rate and C-reactive protein were elevated. Rheumatoid factor was negative. Uric acid levels were normal. Joint aspirate culture was negative. Anti-citrullinated cyclic peptide was strongly positive. Following treatment using diseasemodifying anti-rheumatic drugs, patient improved signi icantly. Conclusion Our case did not have the classical features of rheumatoid arthritis. Monoarticular presentation of rheumatoid arthritis is rare, of which isolated wrist involvement is even rarer. Rheumatoid arthritis should be considered in the differential diagnoses of monoarticular arthritis, and anticitrullinated cyclic peptide should be used more frequently to diagnose rheumatoid arthritis in doubtful cases.

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Clinical Utility of the Anti‐CCP Assay: Experiences with 700 Patients

Cited by 60 publications

References 8 publications

Diagnostic Value of Autoantibodies Against Citrullinated Peptide Antigens in Rheumatoid Arthritis: Comparison of Different Commercial Kits

Diagnostic Value of Autoantibodies Against Citrullinated Peptide Antigens in Rheumatoid Arthritis: Comparison of Different Commercial Kits

Anti-cyclic citrullinated peptide antibodies and rheumatoid factor in leprosy patients with articular involvement

Monoarticular rheumatoid arthritis of the wrist: a rare entity

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