Clinical Utility of Measurement of Anti-Müllerian Hormone in Reproductive Endocrinology

Ledger, William

doi:10.1210/jc.2010-0701

Cited by 80 publications

(70 citation statements)

References 108 publications

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“…Averages and standard error of the mean (SEM) are shown for each age group a yes means cyclic swelling; no means no swelling; irr means irregular swelling b Lower detection limit was 0.16 mg/ml c % of animals ovulating in the Old group is significantly higher than the % in the Young group. The Middle-aged group does not differ from the other two the present analysis, studies of this hormone in humans (Ledger 2010;Shebl et al 2011) and cynomolgus monkeys (Appt et al 2009) suggest that serum levels of AMH are a good index of the number of oocytes present in the ovary. Further study with a larger number of chimpanzees may confirm this pattern in these apes as well.…”

Section: Discussionmentioning

confidence: 43%

Menopause occurs late in life in the captive chimpanzee (Pan troglodytes)

Herndon

Paredes

Wilson

et al. 2011

AGE

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Menopause in women occurs at mid-life. Chimpanzees, in contrast, continue to display cycles of menstrual bleeding and genital swelling, suggestive of ovulation, until near their maximum life span of about 60 years. Because ovulation was not confirmed hormonally, however, the age at which chimpanzees experience menopause has remained uncertain. In the present study, we provide hormonal data from urine samples collected from 30 female chimpanzees, of which 9 were old (>30 years), including 2 above the age of 50 years. Eight old chimpanzees showed clear endocrine evidence of ovulation, as well as cycles of genital swelling that correlated closely with measured endocrine changes. Endocrine evidence thus confirms prior observations (cyclic anogenital swelling) that menopause is a late-life event in the chimpanzee. We also unexpectedly discovered an idiopathic anovulation in some young and middle-aged chimpanzees; this merits further study. Because our results on old chimpanzees validate the use of anogenital swelling as a surrogate index of ovulation, we were able to combine data on swelling and urinary hormones to provide the first estimates of age-specific rates of menopause in chimpanzees. We conclude that menopause occurs near 50 years of age in chimpanzees as it does in women. Our finding identifies a basic difference between the human and chimpanzee aging processes: female chimpanzees can remain reproductively viable for a greater proportion of their life span than women. Thus, while menopause marks the end of the chimpanzee's life span, women may thrive for decades more.

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Section: Discussionmentioning

confidence: 43%

Menopause occurs late in life in the captive chimpanzee (Pan troglodytes)

Herndon

Paredes

Wilson

et al. 2011

AGE

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“…Menopause represents the loss of ovarian reserve and is an inevitable life event for all women who live long enough. [2, 3] The timing of this life event is associated with multiple chronic diseases such as breast cancer (late menopause) and coronary heart disease, stroke, and osteoporosis (early menopause)[4–9]. Thus, biomarkers that can estimate ovarian reserve and the onset of menopause may also have utility in identifying women at low or high risk of common chronic diseases.…”

Section: Introductionmentioning

confidence: 99%

“…[3] AMH has recently emerged as a potentially useful biomarker of ovarian reserve and of the timing of future menopause. Its utility in estimating the onset of menopause has been demonstrated in regularly cycling women from Dutch, Iranian, and US cohorts.…”

Section: Introductionmentioning

confidence: 99%

Anti-mullerian hormone (AMH) is associated with natural menopause in a population-based sample: The CARDIA Women's Study

et al. 2015

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Objective AMH is associated with menopausal timing in several studies. In contrast to prior studies that were restricted to women with regular cycles, our objective was to examine this association in women with either regular or irregular menstrual cycles. Methods CARDIA is a longitudinal, population-based study that recruited adults ages 18–30 when it began in 1985–86. AMH was measured in serum stored in 2002–03. Natural menopause was assessed by survey in 2005–06 and 2010–11. Results Among 716 premenopausal women, median [25th, 75th] AMH was 0.77 [0.22–2.02] ng/dL at a median age of 42 [39–45] years. Twenty-nine percent of the women (n=207) reported natural menopause during 9 years of follow up. In fully adjusted discrete-time hazard models, a 0.5 ng/dL AMH decrement was associated with higher risk of menopause (p<0.001). Hazard ratios varied with time since AMH measurement. The HR (95% CI) for menopause was 8.1 (2.5–26.1) within 0–3 years and 2.3 (1.7–3.3) and 1.6 (1.3–2.1) for 3–6 and 6–9 years, respectively. When restricted to women with regular menses, results were similar (e.g., HR=6.1; 95% CI: 1.9–20.0 for 0–3 years). Conclusion AMH is independently associated with natural menopause. AMH appears most useful in identifying women at risk of menopause in the near future (within 3 years of AMH measurement).

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“…These reproductive disorders include polycystic ovary syndrome (PCOS) (1), irregular menses (2, 3), and subfertility (4, 5). Anti-Müllerian hormone (AMH) is a dimeric glycoprotein produced solely by ovarian follicles (6). A previous cross-sectional report has suggested that AMH concentrations were lower among reproductive-aged Chilean women with type 1 diabetes (n=66) compared to women without type 1 diabetes (n=58) (7).…”

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confidence: 99%

Antimüllerian hormone among women with and without type 1 diabetes: the Epidemiology of Diabetes Interventions and Complications Study and the Michigan Bone Health and Metabolism Study

Kim

Karvonen‐Gutierrez

Kong

et al. 2016

Fertility and Sterility

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Structured Abstract Objective To compare concentrations of anti-Müllerian hormone (AMH) in women with and without type 1 diabetes. Design Cross-sectional analysis of longitudinal studies adjusting for repeated measures Setting Michigan Bone Health and Metabolism Study (MBHMS), a community-based population and the Epidemiology of Interventions and Complications Study (EDIC), an observational cohort of women with type 1 diabetes. Participants Women who were aged 30–45 years and had not undergone oophorectomy, hysterectomy, or natural menopause at the time of AMH measurement were included (n=376 in MBHMS and n=321 in EDIC). Linear mixed regression was used to evaluate whether AMH concentrations differed by diabetes status adjusting for repeated measurements of AMH within individual women, body mass index, smoking status, and oral contraceptive use. Interventions None Main Outcome Measure AMH concentrations Results Prior to 35 years of age, logAMH concentrations were significantly lower among women with type 1 diabetes compared to women without diabetes (β-coefficient −1.27, 95% confidence interval [−2.18, −0.36] in fully-adjusted models). Conclusions Prior to 35 years of age, women with type 1 diabetes have lower AMH levels than women without diabetes. Further investigation is needed to determine the etiologies of this difference and how it may contribute to reproductive disorders among women with type 1 diabetes.

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Clinical Utility of Measurement of Anti-Müllerian Hormone in Reproductive Endocrinology

Cited by 80 publications

References 108 publications

Menopause occurs late in life in the captive chimpanzee (Pan troglodytes)

Menopause occurs late in life in the captive chimpanzee (Pan troglodytes)

Anti-mullerian hormone (AMH) is associated with natural menopause in a population-based sample: The CARDIA Women's Study

Antimüllerian hormone among women with and without type 1 diabetes: the Epidemiology of Diabetes Interventions and Complications Study and the Michigan Bone Health and Metabolism Study

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