Clinical utility of integrated positron emission tomography/computed tomography imaging in the clinical management and radiation treatment planning of locally advanced rectal cancer

A review of interventions to reduce inter‐observer variability in volume delineation in radiation oncology

“…Breast MRI improved IOV in delineation of tumour bed in one of two studies and GTV in another, but there was no improvement in CTV variability in the three studies which assessed this . The use of registered PET scans reduced IOV in all three lung cancer studies and in all four rectal cancer studies, although this was confined to rectal GTV in two studies . Registered PET scans did not reduce delineation variability for head and neck cancers .…”

“…Some studies compared volume delineation on two separate imaging modalities including two different CT scans, CT vs MRI, CT vs cone‐beam CT and MRI scans using different sequences . Other studies compared standard imaging with the use of additional registered data sets such as specialised CT, MRI and PET . This refers to the importation of additional imaging as secondary data sets into the radiotherapy planning system and registration to the simulation CT usually using anatomical bony landmarks.…”

“…53,54 Other studies compared standard imaging with the use of additional registered data sets such as specialised CT 55 , MRI [56][57][58] and PET. 1,[59][60][61][62][63][64][65][66][67] This refers to the importation of additional imaging as secondary data sets into the radiotherapy planning system and registration to the simulation CT usually using anatomical bony landmarks. There was one study each which compared the use of registered vs non-registered PET, 68 registered vs non-registered MRI 69 and 2D vs 3D imaging.…”

Dual-time-point Imaging and Delayed-time-point Fluorodeoxyglucose-PET/Computed Tomography Imaging in Various Clinical Settings

“…2). 30 The impact of this imaging technique on diagnosis, prognosis, 31 and treatment planning 32 has been assessed for different malignant and benign diseases, 33 and the benefits and pitfalls of DTPI are shown in Table 2.…”

Anorectal Cancer: Critical Anatomic and Staging Distinctions That Affect Use of Radiation Therapy

“…In a small study of 34 patients with T3-T4, N0-N1, and M0-M1 disease, Whaley et al (44) found that PET/CT altered staging in 18% of patients and improved interobserver concordance in contouring boost treatment volumes compared with CT alone. This may be due to the superior ability of PET/ CT to delineate tumor volume, which serves to minimize treatment margins and exclude nondiseased tissue (40).…”