Clinical utility of external immunoscintigraphy with the IMMU-4 technetium-99m Fab' antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum: results of a pivotal, phase III trial. The Immunomedics Study Group.

Moffat, F.; Pinsky, Carl M.; Hammershaimb, Luz; Petrelli, Nicholas J.; Patt, Yehuda Z.; Whaley, F S; Goldenberg, D. M.

doi:10.1200/jco.1996.14.8.2295

Cited by 121 publications

(47 citation statements)

References 14 publications

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“…The panel does not recommend the use of anti-CEA--radiolabeled scintigraphy. 252 In the event that surgically curable metastatic disease is identified on CT or MRI, the panel does recommend a PET scan before surgical resection to look for evidence of additional metastases that may change the status of patient resectability.…”

Section: Managing An Increasing Carcinoembryonic Antigen Levelmentioning

confidence: 99%

Positive lymph node retrieval ratio optimises patient staging in colorectal cancer

et al. 2009

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These guidelines are a statement of evidence and consensus of the authors regarding their views of currently accepted approaches to treatment. Any clinician seeking to apply or consult these guidelines is expected to use independent medical judgment in the context of individual clinical circumstances to determine any patient's care or treatment. The National Comprehensive Cancer Network makes no representations nor warranties of any kind whatsoever regarding their content, use, or application and disclaims any responsibility for their application or use in any way. These guidelines are copyrighted by National Comprehensive Cancer Network. All rights reserved. These guidelines and the illustrations herein may not be reproduced in any form without the express written permission of NCCN. ©2009. 6. General. This Agreement contains the entire agreement between NCCN and you relating to its subject matter. No amendment, change, or modification of this Agreement shall be binding on either party unless mutually agreed to by the parties in writing. If any provision of this Agreement is held to be invalid or unenforceable by a court of competent jurisdiction, the validity and enforceability of the remaining provisions shall not be affected thereby. This Agreement will be governed by and construed in accordance with the laws of the Commonwealth of Pennsylvania without giving any effect to the conflict of law provisions thereof, and each party agrees to submit to personal jurisdiction in the federal and state courts of Pennsylvania and waives any objection to venues in said courts. This Agreement will not be governed by the United Nations Conventions of Contracts for the International Sale of goods, the application of which is expressly excluded. You agree that the Guidelines will not be shipped, transferred or exported into any country or used in any manner prohibited by the United States Export Administration Act, or any other export laws, restrictions. This Agreement will terminate automatically upon failure by you to comply with its terms. NCCN MAKES NO WARRANTIES CONCERNING THE GUIDELINES OR ANY ELECTRONIC DELIVERY MEDIA SUPPLIED BY NCCN, WHICH ARE PROVIDED "AS IS." NCCN DISCLAIMS ALL WARRANTIES, EXPRESS OR IMPLIED INCLUDING, WITHOUT LIMITATION, THE IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE. NCCN DOES NOT WARRANT THE ACCURACY OR COMPLETENESS OF THE GUIDELINES AND DOES NOT WARRANT OR GUARANTEE OR MAKE ANY REPRESENTATION REGARDING THE USE OR THE RESULTS OF THE USE OF THE GUIDELINES. IN NO EVENT SHALL NCCN OR ITS MEMBERS BE LIABLE FOR ANY INCIDENTAL, INDIRECT, SPECIAL, PUNITIVE OR CONSEQUENTIAL DAMAGES ARISING OUT OF OR IN CONNECTION WITH THE LICENSE GRANTED UNDER THIS AGREEMENT OR USE OF THE GUIDELINES INCLUDING, WITHOUT LIMITATION, LOSS OF LIFE, LOSS OF DATA, LOSS OF INCOME OR PROFIT, OR OTHER LOSSES SUSTAINED AS A RESULT OF INJURY TO ANY PERSON, OR LOSS OR DAMAGE TO PROPERTY, OR CLAIMS OF THIRD PARTIES, EVEN IF NCCN HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. SOME JURISDICTION...

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Section: Managing An Increasing Carcinoembryonic Antigen Levelmentioning

confidence: 99%

Positive lymph node retrieval ratio optimises patient staging in colorectal cancer

et al. 2009

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“…By using this Raman-modified endoscope, Shim et al (383) demonstrated that Raman spectra of human gastrointestinal tissues could be obtained with acceptable signal-to-noise ratio and good temporal resolution. Moreover, through the use of diagnostic algorithms for classifying colon polyps based on their spectral characteristics, adenomatous polyps could be differentiated from hyperplastic polyps with great accuracy (296,383).…”

Section: Raman Imagingmentioning

confidence: 99%

A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications

James

Gambhir

2012

Physiological Reviews

940

954

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Molecular imaging is revolutionizing the way we study the inner workings of the human body, diagnose diseases, approach drug design, and assess therapies. The field as a whole is making possible the visualization of complex biochemical processes involved in normal physiology and disease states, in real time, in living cells, tissues, and intact subjects. In this review, we focus specifically on molecular imaging of intact living subjects. We provide a basic primer for those who are new to molecular imaging, and a resource for those involved in the field. We begin by describing classical molecular imaging techniques together with their key strengths and limitations, after which we introduce some of the latest emerging imaging modalities. We provide an overview of the main classes of molecular imaging agents (i.e., small molecules, peptides, aptamers, engineered proteins, and nanoparticles) and cite examples of how molecular imaging is being applied in oncology, neuroscience, cardiology, gene therapy, cell tracking, and theranostics (therapy combined with diagnostics). A step-by-step guide to answering biological and/or clinical questions using the tools of molecular imaging is also provided. We conclude by discussing the grand challenges of the field, its future directions, and enormous potential for further impacting how we approach research and medicine.

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“…(48). Hepatic uptake of this agent hindered interpretation of possible metastases in the liver, but a 99m Tc-labeled anti -carcinoembryonic antigen (CEA) FabV fragment improved the visualization of tumors in the liver (49). Currently, [ 18 F]deoxyglucose, with the improved sensitivity afforded by positron emission tomography imaging systems, has become the standard for oncology radionuclide imaging.…”

Section: Pretargeting For Improved Imagingmentioning

confidence: 99%

Improving the Delivery of Radionuclides for Imaging and Therapy of Cancer Using Pretargeting Methods

Sharkey

Karacay

Cardillo

et al. 2005

Clinical Cancer Research

113

102

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The article reviews the background and current status of pretargeting for cancer imaging and therapy with radionuclides. Pretargeting procedures were introduced f20 years ago as an alternative to directly radiolabeled antibodies. Because they were multistep processes, they were met with resistance but have since progressed to simple and improved procedures that could become the next generation of imaging and therapy with radionuclides. The separation of the radiolabeled compound from the antibody-targeting agent affords pretargeting procedures considerable flexibility in the radiolabeling process, providing opportunities for molecular imaging using g-or positron-emitting radionuclides and a variety of h-and a-emitting radionuclides of therapeutic applications. Pretargeting methods improve tumor/ nontumor ratios, exceeding that achieved with directly radiolabeled FabV fragments, particularly within just a few hours of the radionuclide injection. In addition, tumor uptake exceeds that of a FabV fragment by as much as 10-fold, giving pretargeting a greatly enhanced sensitivity for imaging. Advances in molecular biology have led to the development of novel binding proteins that have further improved radionuclide delivery in these systems. Studies in a variety of hematologic and solid tumor models have shown advantages of pretargeting compared with directly radiolabeled IgG for therapy, and there are several clinical studies under way that are also showing promising results. Thus, the next generation of targeting agents will likely employ pretargeting approaches to optimize radionuclide delivery for a wide range of applications.Radiation continues to play an integral role in the management of cancer, from the use of X-rays and computed tomography for detection to the use of external beam and interstitial radiotherapy (brachytherapy and rapid interstitial therapy) for treatment. Nuclear medicine, which involves the use of internally administered radionuclides, traditionally has played a minor role in the management of cancer, initially relying primarily on the use of [ 67 Ga]citrate for lymphoma imaging and 131 INa for thyroid cancer treatment. However, with the advent of positron emission tomography and [ 18 F]deoxyglucose, and thanks to the development of new antibody-guided therapeutics for non-Hodgkin's lymphoma and emerging peptide-targeted therapeutics, the role of nuclear medicine in the management of cancer is increasing (1, 2).Except for 131 INa and radionuclides used for palliation of bone pain that are selectively taken up by their respective tissues, the specificity for cancer of internally administered radionuclides depends on its coupling to a targeting compound. For example, [18 F]deoxyglucose is concentrated in cancers because they are more metabolically active than most other cells in the body and therefore will accrue more deoxyglucose than surrounding cells. Antibodies have been one of the most commonly used targeting agents, with an extensive history spanning over 50 years (3). During this...

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Clinical utility of external immunoscintigraphy with the IMMU-4 technetium-99m Fab' antibody fragment in patients undergoing surgery for carcinoma of the colon and rectum: results of a pivotal, phase III trial. The Immunomedics Study Group.

Abstract: CEA-Scan affords high-quality, same-day imaging, uses an inexpensive and readily available radio-nuclide, adds clinically significant information in assessing extent and location of disease in colorectal cancer patients, and only rarely induces a HAMA response.

Cited by 121 publications

References 14 publications

Positive lymph node retrieval ratio optimises patient staging in colorectal cancer

Positive lymph node retrieval ratio optimises patient staging in colorectal cancer

A Molecular Imaging Primer: Modalities, Imaging Agents, and Applications

Improving the Delivery of Radionuclides for Imaging and Therapy of Cancer Using Pretargeting Methods

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