Clinical Utility of Circulating Tumor DNA for Detecting Lung Cancer Mutations by Targeted Next‐Generation Sequencing With Insufficient Tumor Samples
Yi Sun,
Xu Zhang,
Xinhua Yang
et al.
Abstract:BackgroundCirculating tumor deoxyribonucleic acid (ctDNA) is increasingly applied in clinical practice. This study aimed to explore clinical utility of a minimal invasive and sensitive way of ctDNA for next‐generation sequencing in non–small cell lung cancer (NSCLC) with inadequate tumor samples.MethodsTargeted DNA sequencing was performed on tissue biopsies and matched plasma samples from 60 patients with NSCLC.ResultsA total of 13 driving genes were detected in 60 matched tissue DNA (tDNA) and ctDNA samples.… Show more
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