Clinical utility of bone markers in various diseases

Vlot, Mariska C.; Heijer, Martin den; Jongh, Renate T. de; Vervloet, Marc G.; Lems, W.F.; Jonge, Robert de; Obermayer–Pietsch, Barbara; Heijboer, Annemieke C.

doi:10.1016/j.bone.2018.06.011

Cited by 57 publications

(49 citation statements)

References 175 publications

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“…Almost all treatments of rheumatoid arthritis lead to increased levels of procollagen type I amino-terminal propeptide (PINP). Nevertheless, PINP levels may remain stable following infliximab use or even decrease after denosumab therapy [25].…”

Section: Resultsmentioning

confidence: 99%

Biochemical Markers of Bone Turnover in Rheumatoid Arthritis Patients Treated with Glucocorticoids

Macovei¹,

Burlui²,

Rezuş³

2019

Rev. Chim.

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Osteocalcin and deoxypyridinoline levels were measured in 55 RA patients during and after glucocorticoid therapy with prednisone, methylprednisolone and cortisone. A decrease of 27% of the bone resorption marker deoxypyridinoline (from 10.13 to 7.4) and an increase of 23% of the bone formation marker osteocalcin (from 16.3 to 20.1) were also clinically confirmed by the presence of osteoporosis in 74% of patients receiving corticosteroid treatment as compared with only 31% in the control group.

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Section: Resultsmentioning

confidence: 99%

Biochemical Markers of Bone Turnover in Rheumatoid Arthritis Patients Treated with Glucocorticoids

Macovei¹,

Burlui²,

Rezuş³

2019

Rev. Chim.

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“…The bone formation marker P1NP resembles osteoblast activity and was measured using an immunoassay (Cobas; Roche Diagnostics, Mannheim, Germany), with an interassay coefficient of variation (CV) of <8% and a lower limit of quantification (LOQ) of 5 µg/L.…”

Section: Methodsmentioning

confidence: 99%

“…The bone resorption marker CTx displays osteoclast activity . CTx was measured using an immunoassay (Cobas; Roche Diagnostics), with an interassay CV of <6.5% and a LOQ of 10 ng/L.…”

Section: Methodsmentioning

confidence: 99%

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Gender-Affirming Hormone Treatment Decreases Bone Turnover in Transwomen and Older Transmen

Vlot

Wiepjes

Jongh

et al. 2019

Journal of Bone and Mineral Research

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Sex steroids play a key role in bone turnover and preserving BMD; hence, gender-affirming hormone treatment (HT) in transgender people affects bone metabolism. Most studies have looked into the effect of HT on changes in BMD; however, they do not provide insights into changes in bone metabolism caused by HT. This study investigated changes in bone turnover markers (BTMs) and sclerostin, as well as their correlations with change in BMD in transwomen and transmen during the first year of HT. Transwomen received estradiol and antiandrogens; transmen received testosterone. Sclerostin; P1NP; alkaline phosphatase (ALP); CTx; and BMD of the total hip, the femoral neck, and the lumbar spine were evaluated at baseline and after 1 year of HT. There were 121 transwomen (median age 30 years, interquartile range [IQR] 24 to 41 years) and 132 transmen (median age 24 years, IQR 21 to 33 years) included in the study. In transwomen, ALP decreased in 19% (95% CI, -21 to-16), CTx in 11% (95% CI, -18 to-4), and sclerostin in 8% (95%CI, -13 to-4) of study participants after 1 year of HT. In contrast, in transmen P1NP, ALP, and sclerostin increased in 33% (95% CI, 24 to 42), 16% (95% CI, 12 to 20), and 15% (95% CI, 10 to 20) of study participants, respectively, after 1 year of HT. No age differences were seen in transwomen, whereas in transmen aged ≥50 years a decrease in all BTMs was found in contrast with the other age groups. These transmen had low estrogen concentration at the start of HT based on their postmenopausal state before the start of HT; their estradiol concentrations increased during testosterone treatment. Changes in BTMs and BMD were weakly correlated (correlation coefficient all <0.30). To conclude, 1 year of HT resulted in decreased bone turnover in transwomen and older transmen, whereas it increased in younger transmen. The decrease in bone resorption in older transmen shows the importance of estrogen as a key regulator of bone turnover.■ 1864 VLOT ET AL. HT = gender-affirming hormonal treatment; IQR = interquartile range; LH = luteinizing hormone; AST = aspartate transaminase; ALT = alanine transaminase; γGT = gamma-glutamyltransferase. Journal of Bone and Mineral Research■ 1866 VLOT ET AL.

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“…bone markers) [12]. Oni mogu, takođe, dati rane informacije o poremećenom sticanju koštane mase u pubertetu i adolesceniji, a imaju i prognostičku vrijednost u odnosu na pojavu stres fraktura [12,13]. U kliničke i istraživačke svrhe se koristi nekoliko različitih koštanih markera.…”

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Effect of type of sport, weekly physical exertion and body mass index on values of bone turnover markers in elite female athletes

Ponorac¹,

Sobot²,

Rašeta³

2018

Biomedicinska istraž.

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Uvod. Cilj ovog istraživanja je bio da se odrede koncentracijemarkera koštanog metabolizma (srednji fragment osteokalcina iβ-CrossLaps) u serumu sportistkinja koje se bave različitim sportovima,kao i njihova povezanost sa vrstom sporta, sedmičnimfizičkim opterećenjem i indeksom tjelesne mase.Metode. Od ukupno 111 ispitanica 78 su bile elitne sportistkinjedok su kontrolnu grupu činile 33 studentkinje medicinskog fakultetaslične dobi. Iz studije su isključene sportistkinje sa bilo kojomvrstom menstrualne neregularnosti (N = 18). Tako je uzorak činilo27 sportistkinja koje se bave sportovima igara sa loptom, 11 atletičarkii 22 sportistkinje koje se bave plesom.Rezultati. Sportistkinje iz grupe igara sa loptom imale suznačajno veći indeks tjelesne mase i značajno duži sportskistaž u odnosu na druge dvije grupe, dok su sportistkinje izgrupe plesa imale i značajno najmanje sedmično fizičko opterećenje.Utvrđena je statistički značajna razlika u vrijednostimakoštanih markera osteokalcina (49,55 ± 16,83 vs. 36,13± 7,26; p = 0,001) i β-CrossLaps (0,75 ± 0,25 vs. 0,53 ± 0,14;p= 0,001) između sportistkinja i ispitanica kontrolne grupe. Sportistkinjekoje se bave igrama sa loptom su imale veći osteogeni efekatu odnosu na one koje se bave atletikom i plesom (p < 0,05).Pokazana je značajna povezanosti između sedmičnog fizičkog opterećenjai indeksa tjelense mase sa vrijednostima koštanih markera.Zaključak. Hronična fizička aktivnost ispoljava osteogeni efekatšto potvrđuje koncentracija serumskog osteokalcina koji je značajnopovezan sa sedmičnim fizičkim opterećenjem.

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Clinical utility of bone markers in various diseases

Cited by 57 publications

References 175 publications

Biochemical Markers of Bone Turnover in Rheumatoid Arthritis Patients Treated with Glucocorticoids

Biochemical Markers of Bone Turnover in Rheumatoid Arthritis Patients Treated with Glucocorticoids

Gender-Affirming Hormone Treatment Decreases Bone Turnover in Transwomen and Older Transmen

Effect of type of sport, weekly physical exertion and body mass index on values of bone turnover markers in elite female athletes

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