Clinical utility of 18F-FDG-PET/MRI brain in dementia: Preliminary experience from a geriatric clinic in South India

Mukku, Shiva Shanker Reddy; Sivakumar, Palanimuthu T.; Nagaraj, Chandana; Mangalore, Sandhya; Harbishettar, Vijaykumar; Varghese, Mathew

doi:10.1016/j.ajp.2019.07.001

Cited by 11 publications

(9 citation statements)

References 31 publications

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“…F type of molecular imaging that is based on astrocyte/neuronal glucose consumption, and 18 F-FDG uptake is considered a direct indicator of synaptic dysfunction [41,42]. Hypometabolism reflects genuine functional damage because glucose is vital for the brain to participate in various critical functions, such as adenosine triphosphate production, oxidative stress management, and synthesis of neurotransmitters, neuromodulators, and structural components [42]. Coupling between function network and cognition was found stronger in presymptomatic carriers, also provide evidence that the independent and synergistic effects exist in different image modalities [43].…”

Section: Discussionmentioning

confidence: 99%

Investigating the Roles of Anterior Cingulate in Behavioral Variant Frontotemporal Dementia: A PET/MRI Study

Chu

Liu

Wang

et al. 2021

JAD

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Background: The anterior cingulate cortex (ACC) seems to play an important role in behavioral deficits and executive dysfunctions in patients with behavior-variant frontotemporal dementia (bvFTD), while its specific and independent contribution requires clarification. Objective: To identify whether ACC abnormalities in gray matter (GM) volume and standardized uptake value ratio (SUVR) images are associated with disease severity of bvFTD, by analyzing hybrid T1 and 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET). Methods: We enrolled 21 bvFTD patients and 21 healthy controls in the study. Each subject underwent a hybrid PET/MRI study and a standardized neuropsychologic assessment battery. GM volume and SUVR are voxel-wise calculated and compared. Then we estimate the mean value inside ACC for further partial Pearson’s correlation to explore the association between GM volume/SUVR of the ACC and severity of behavioral deficit as well as executive dysfunction. Results: ACC was shown to be involved in both atrophy and hypometabolism patterns. The partial Pearson’s correlation analysis showed that the SUVR of the ACC was strongly correlated with frontal behavior inventory total score (left r = –0.85, right r = –0.85, p < 0.0001), disinhibition subscale score (left r = –0.72, p = 0.002; right = –0.75, p < 0.0001), and apathy subscale score (left = –0.87, right = –0.85, p < 0.0001). Conclusion: These findings demonstrated decreased ACC activity contributes to behavioral disturbances of both apathetic and disinhibition syndromes of bvFTD, which can be sensitively detected using 18F-FDG PET.

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Section: Discussionmentioning

confidence: 99%

Investigating the Roles of Anterior Cingulate in Behavioral Variant Frontotemporal Dementia: A PET/MRI Study

Chu

Liu

Wang

et al. 2021

JAD

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“…2 Despite these constraints, recently published integrated PET/MRI studies have shown improved diagnostic accuracy in identifying and distinguishing dementia from HCs (Table 5). 2,147,154–159 In a recent study, hybrid FDG-PET/MRI revealed 35% more vascular pathology, changed the PET interpretation in 17% of patients, and altered management in 22%. The higher reader confidence of FDG-PET findings improves the assessment of the structural correlates of MRI.…”

Section: Current Status and Future Perspective Of Multimodality Pet/mri Neuroimaging As A Potential Diagnostic Biomarker In The Clinical mentioning

confidence: 99%

“…The MCI group indicated underlying etiology, and in the dementia group, it helped in subtyping. 158 Simultaneous amyloid PET/MRI is feasible and provides high patient/caregiver and referrer acceptance of a new one-stop-shop dual AD biomarker (amyloid-beta load and MTLA) delivery approach. 155 Nonamnestic AD variant (posterior cortical atrophy, lvPPA), differs from amnestic AD in distributions of tau aggregates and neurodegeneration.…”

Section: Current Status and Future Perspective Of Multimodality Pet/mri Neuroimaging As A Potential Diagnostic Biomarker In The Clinical mentioning

confidence: 99%

Multiparametric magnetic resonance imaging and positron emission tomography findings in neurodegenerative diseases: Current status and future directions

et al. 2021

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Neurodegenerative diseases (NDDs) are characterized by progressive neuronal loss, leading to dementia and movement disorders. NDDs broadly include Alzheimer’s disease, frontotemporal lobar degeneration, parkinsonian syndromes, and prion diseases. There is an ever-increasing prevalence of mild cognitive impairment and dementia, with an accompanying immense economic impact, prompting efforts aimed at early identification and effective interventions. Neuroimaging is an essential tool for the early diagnosis of NDDs in both clinical and research settings. Structural, functional, and metabolic imaging modalities, including magnetic resonance imaging (MRI) and positron emission tomography (PET), are widely available. They show encouraging results for diagnosis, monitoring, and treatment response evaluation. The current review focuses on the complementary role of various imaging modalities in relation to NDDs, the qualitative and quantitative utility of newer MRI techniques, novel radiopharmaceuticals, and integrated PET/MRI in the setting of NDDs.

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“…74 In practice, MRI and PET images are often interpreted by different subspecialist radiologists, with integration of these separate findings often left to the referring clinician. 75 Mukku et al 43 examined the diagnostic utility of 18 FDG-PET/MRI in dementia diagnoses, finding that biomarkers of hypometabolism and structural atrophy showed 90.5% concordance with clinical diagnoses, and further assisted with diagnostic subtyping.…”

Section: Diagnostic Utilitymentioning

confidence: 99%

The use of positron emission tomography/magnetic resonance imaging in dementia: A literature review

Lorking

Murray

O’Brien

2021

Int J Geriat Psychiatry

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Objectives Positron emission tomography–magnetic resonance imaging (PET/MRI) is an emerging hybrid imaging system in clinical nuclear medicine. Research demonstrates a comparative utility to current unimodal and hybrid methods, including PET‐computed tomography (PET/CT), in several medical subspecialities such as neuroimaging. The aim of this review is to critically evaluate the literature from 2016 to 2021 using PET/MRI for the investigation of patients with mild cognitive impairment or dementia, and discuss the evidence base for widening its application into clinical practice. Methods A comprehensive literature search using the PubMed database was conducted to retrieve studies using PET/MRI in relation to the topics of mild cognitive impairment, dementia, or Alzheimer's disease between January 2016 and January 2021. This search strategy enabled studies on all dementia types to be included in the analysis. Studies were required to have a minimum of 10 human subjects and incorporate simultaneous PET/MRI. Results A total of 116 papers were retrieved, with 39 papers included in the final selection. These were broadly categorised into reviews (12), technical/methodological papers (11) and new data studies (16). For the current review, discussion focused on findings from the new data studies. Conclusions PET/MRI offers additional insight into the underlying anatomical, metabolic and functional changes associated with dementia when compared with unimodal methods and PET/CT, particularly relating to brain regions including the hippocampus and default mode network. Furthermore, the improved diagnostic utility of PET/MRI, as reported by radiologists, offers improved classification of dementia patients, with important implications for clinical management.

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Clinical utility of 18F-FDG-PET/MRI brain in dementia: Preliminary experience from a geriatric clinic in South India

Cited by 11 publications

References 31 publications

Investigating the Roles of Anterior Cingulate in Behavioral Variant Frontotemporal Dementia: A PET/MRI Study

Investigating the Roles of Anterior Cingulate in Behavioral Variant Frontotemporal Dementia: A PET/MRI Study

Multiparametric magnetic resonance imaging and positron emission tomography findings in neurodegenerative diseases: Current status and future directions

The use of positron emission tomography/magnetic resonance imaging in dementia: A literature review

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