Clinical uses of microbubbles in diagnosis and treatment

Cosgrove, David O.; Harvey, Chris J.

doi:10.1007/s11517-009-0434-3

Cited by 104 publications

(66 citation statements)

References 92 publications

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“…Colour and power Doppler are limited by the low sensitivity to low-velocity flow in smaller vessels (<2 mm in diameter). Contrastenhanced ultrasound (CEUS) with microbubble contrast agents [6][7][8] has recently been proposed as a new imaging technique for quantifying tissue perfusion [9,10]. CEUS presents several advantages including low cost, portability, availability, lack of restrictions in performing serial examinations at short intervals, and absence of exposure to radiation or nuclear tracers.…”

Section: Introductionmentioning

confidence: 99%

Assessment of tissue perfusion by contrast-enhanced ultrasound

Quaia

2010

Eur Radiol

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Section: Introductionmentioning

confidence: 99%

Assessment of tissue perfusion by contrast-enhanced ultrasound

Quaia

2010

Eur Radiol

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“…10,11 This is an attractive approach since gas bubbles are well established as contrast agents for ultrasound imaging. [12][13][14][15] In this case, the microbubble oscillations are stimulated by the heating and cooling of the coating and subsequently of the gas core upon optical irradiation.…”

Section: Introductionmentioning

confidence: 99%

Laser-driven resonance of dye-doped oil-coated microbubbles: A theoretical and numerical study

Lajoinie

Linnartz

Kruizinga

et al. 2017

The Journal of the Acoustical Society of America

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Microbubbles are used to enhance the contrast in ultrasound imaging. When coated with an optically absorbing material, these bubbles can also provide contrast in photoacoustic imaging. This multimodal aspect is of pronounced interest to the field of medical imaging. The aim of this paper is to provide a theoretical framework to describe the physical phenomena underlying the photoacoustic response. This article presents a model for a spherical gas microbubble suspended in an aqueous environment and coated with an oil layer containing an optically absorbing dye. The model includes heat transfer between the gas core and the surrounding liquids. This framework is suitable for the investigation of both continuous wave and pulsed laser excitation. This work utilizes a combination of finite difference simulations and numerical integration to determine the dependancy on the physical properties, including composition and thickness of the oil layer on the microbubble response. A normalization scheme for a linearized version of the model was derived to facilitate comparison with experimental measurements. The results show that viscosity and thickness of the oil layer determine whether or not microbubble resonance can be excited. This work also examines the use of non-sinusoidal excitation to promote harmonic imaging techniques to further improve the imaging sensitivity.

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“…[1][2][3] However, their use is not without potential risks. Although UCAs exposed to low pressure ultrasound have a very low risk of damaging cellular structures, 4 as the pressure is increased, UCAs can eventually violently collapse and cause damage to surrounding cells and tissues.…”

Section: Introductionmentioning

confidence: 99%

Estimating concentration of ultrasound contrast agents with backscatter coefficients: Experimental and theoretical aspects

Leithem¹,

Lavarello²,

O’Brien³

et al. 2012

The Journal of the Acoustical Society of America

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Ultrasound contrast agents (UCAs) have been explored as a means to enhance therapeutic techniques. Because the effectiveness of these techniques relies on the UCA concentration at a target site, it would be beneficial to estimate UCA concentration noninvasively. In this study, a noninvasive method for estimating UCA concentration was developed in vitro. Backscatter coefficients (BSCs) estimated from measurements of Definity V R UCAs were fitted to a theoretical scattering model in the 15-25 MHz range using a Levenberg-Marquardt regression technique. The model was defined by the UCA size distribution and concentration, and therefore concentration estimates were extracted directly from the fit. Calculation of the BSC was accomplished using planar reference measurements from the back wall of a Plexiglas V R chamber and an average of 500 snapshots of ultrasonic backscatter from UCAs flowing through the chamber. In order to verify the ultrasonically derived UCA concentration estimates, a sample of the UCAs was extracted from the flow path and the concentration was estimated with a hemacytometer. UCA concentrations of 1, 2, and 5 times the dose recommended by the manufacturer were used in experiments. All BSC-based estimates were within one standard deviation of hemacytometer based estimates for peak rarefactional pressures of 100-400 kPa.

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Clinical uses of microbubbles in diagnosis and treatment

Cited by 104 publications

References 92 publications

Assessment of tissue perfusion by contrast-enhanced ultrasound

Assessment of tissue perfusion by contrast-enhanced ultrasound

Laser-driven resonance of dye-doped oil-coated microbubbles: A theoretical and numerical study

Estimating concentration of ultrasound contrast agents with backscatter coefficients: Experimental and theoretical aspects

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