Clinical Usefulness of the Platelet-to Lymphocyte Ratio in Patients with Angiosarcoma of the Face and Scalp

Suzuki, Gen; Yamazaki, Hideya; Aibe, Norihiro; Masui, Koji; Sasaki, Nozomu; Shimizu, Daisuke; Kimoto, Tsunenobu; Asai, Jun; Wada, Makoto; Komori, Satoshi; Katoh, Norito; Yamada, Kazuo

doi:10.3390/ijms18112402

Cited by 14 publications

(11 citation statements)

References 34 publications

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“…Endothelial cell junctions are indispensable parts of the BBB and inner BRB (iBRB) in maintaining cerebral and retinal homeostasis [ 35 , 84 , 137 ]. Particularly, CNS tissues possess an enriched expression of tight junctions due to the need for maintenance of the blood barriers [ 84 ].…”

Section: Discussionmentioning

confidence: 99%

Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer’s disease

Shi

Koronyo

Fuchs

et al. 2020

acta neuropathol commun

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Extensive effort has been made studying retinal pathology in Alzheimer’s disease (AD) to improve early noninvasive diagnosis and treatment. Particularly relevant are vascular changes, which appear prominent in early brain pathogenesis and could predict cognitive decline. Recently, we identified platelet-derived growth factor receptor beta (PDGFRβ) deficiency and pericyte loss associated with vascular Aβ deposition in the neurosensory retina of mild cognitively impaired (MCI) and AD patients. However, the pathological mechanisms of retinal vascular changes and their possible relationships with vascular amyloidosis, pericyte loss, and blood-retinal barrier (BRB) integrity remain unknown. Here, we evaluated the retinas of transgenic APPSWE/PS1ΔE9 mouse models of AD (ADtg mice) and wild-type mice at different ages for capillary degeneration, PDGFRβ expression, vascular amyloidosis, permeability and inner BRB tight-junction molecules. Using a retinal vascular isolation technique followed by periodic acid-Schiff or immunofluorescent staining, we discovered significant retinal capillary degeneration in ADtg mice compared to age- and sex-matched wild-type mice (P < 0.0001). This small vessel degeneration reached significance in 8-month-old mice (P = 0.0035), with males more susceptible than females. Degeneration of retinal capillaries also progressively increased with age in healthy mice (P = 0.0145); however, the phenomenon was significantly worse during AD-like progression (P = 0.0001). A substantial vascular PDGFRβ deficiency (~ 50% reduction, P = 0.0017) along with prominent vascular Aβ deposition was further detected in the retina of ADtg mice, which inversely correlated with the extent of degenerated capillaries (Pearson’s r = − 0.8, P = 0.0016). Importantly, tight-junction alterations such as claudin-1 downregulation and increased BRB permeability, demonstrated in vivo by retinal fluorescein imaging and ex vivo following injection of FITC-dextran (2000 kD) and Texas Red-dextran (3 kD), were found in ADtg mice. Overall, the identification of age- and Alzheimer’s-dependent retinal capillary degeneration and compromised BRB integrity starting at early disease stages in ADtg mice could contribute to the development of novel targets for AD diagnosis and therapy.

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Section: Discussionmentioning

confidence: 99%

Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer’s disease

Shi

Koronyo

Fuchs

et al. 2020

acta neuropathol commun

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“…To the best of our knowledge, this is the first study to explore the prognostic value of a set of pretreatment inflammatory indexes including NLR, PLR, MLR, SII, LDH and ALP, in a relatively large clinical setting of 56 patients with this rare sarcoma. There was only one study specifically targeting AS which evaluated the prognostic role of 3 serum markers in 17 patients with ASFS 20. The OS of AS patients at any location was relatively short21 and the major problem is the absence of treatment standards.…”

Section: Discussionmentioning

confidence: 99%

“…Owing to the extreme rarity of this tumor, reports on clinicopathological features and prognostic factors of primary angiosarcoma (PAS) are limited and most of them are case reports or small case series, of which the selection bias makes the results difficult to interpret. Gen Suzuk et al have investigated the role of 3 inflammatory markers in prognosis of 17 patients with AS 20. Our study aims to identify a set of accessible biomarkers in patients’ peripheral blood and clarify their relationships with the overall survival (OS).…”

Section: Introductionmentioning

confidence: 99%

<p>The prognostic value of pretreatment inflammatory biomarkers in primary angiosarcoma</p>

Wang¹,

Wu²,

An³

et al. 2019

CMAR

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BackgroundRecent studies have suggested a significant relationship between inflammatory indexes such as the neutrophil-to-lymphocyte ratio (NLR) and survival outcomes in various cancers. The aim of the present study was to evaluate the prognostic value of 6 pretreatment inflammatory markers in patients with primary angiosarcoma (AS) which is a rare and highly malignant type of soft tissue sarcoma.MethodsFifty-six patients diagnosed with primary AS at West China Hospital between August 2009 and July 2016 were retrospectively enrolled. The value of each biomarker was calculated for its correlation with patients’ overall survival.ResultsThe low tumor grade, tumor size <5 cm, metastatic status, surgical treatment and low level of monocyte-to-lymphocyte ratio, NLR and lactate dehydrogenase (LDH) were correlated with better survival outcome in univariate analyses. In multivariate analyses, high levels of NLR (HR 2.673, 95% CI 1.253–5.703, p=0.011) and LDH (HR 2.964, 95% CI 1.464–5.998, p=0.003) were selected as independent prognostic factors.ConclusionThis study identifies the elevated pretreatment levels of NLR and LDH as prognostic markers in patients with primary AS.

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“…52,54,55 In particular, the neutrophil count of angiosarcoma patients has been shown to be significantly higher than age and gender-matched controls. 56 In veterinary medicine, a higher pre-treatment neutrophil count is negatively correlated with prognosis in canine acute leukaemia 57 and a higher neutrophil:lymphocyte ratio has been shown to correlate negatively with prognosis in canine mast cell tumours. 58 Neutrophil:lymphocyte ratio has also been shown to have use in the differentiation of benign vs malignant canine soft tissue tumours.…”

Section: Csmls Presenting With Haemoabdomenmentioning

confidence: 99%

Refining the “double two‐thirds” rule: Genotype‐based breed grouping and clinical presentation help predict the diagnosis of canine splenic mass lesions in 288 dogs

Davies

Taylor

2020

Vet Comparative Oncology

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Prediction of the likely histopathological diagnosis of canine splenic masses can guide appropriate decision-making. This study explores the predictive effect of breed and clinical presentation on the diagnosis of a canine splenic mass. Records from the Royal Veterinary College, United Kingdom (2007-2017) were reviewed. Dogs with a histopathologic or cytologic diagnosis from a splenic mass, or imaging findings consistent with disseminated metastatic disease, were included. Signalment, physical examination, haematology results, imaging findings and pathology reports were recorded. Breeds were grouped according to several permutations of their phenotype and then by clustering of breeds based on single nucleotide polymorphism analysis. Binary logistic regression was performed to identify predictors of malignancy and haemangiosarcoma. Two hundred and eighty-eight dogs were identified: 27% female and 63% male, 21% entire and 79% neutered; German Shepherd was the most common breed (11%). Median age was 10 years and median bodyweight 25 kg. Thirty-eight percent of dogs presented with haemoabdomen; a splenic mass was found incidentally in 28%. Sixty percent had a malignant tumour of which haemangiosarcoma comprised 66%. On multivariable analysis, genotype-based breed group (P = .004), haemoabdomen (P < .001) and neutrophil count (P = .025) predicted malignancy, and genotype-based breed group (P < .001) and haemoabdomen (P < .001) predicted haemangiosarcoma. Genotype-based breed group and occurrence of haemoabdomen may have predictive value to diagnose malignant splenic masses and more specifically haemangiosarcoma. The effect of genotype-based breed grouping was a superior predictor of the diagnosis of a canine splenic mass lesion compared with all phenotype-based groupings tested.

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Clinical Usefulness of the Platelet-to Lymphocyte Ratio in Patients with Angiosarcoma of the Face and Scalp

Cited by 14 publications

References 34 publications

Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer’s disease

Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer’s disease

<p>The prognostic value of pretreatment inflammatory biomarkers in primary angiosarcoma</p>

Refining the “double two‐thirds” rule: Genotype‐based breed grouping and clinical presentation help predict the diagnosis of canine splenic mass lesions in 288 dogs

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