Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis

Farkas, Nelli; Szabó, Andrea; Lóránd, Veronika; Sarlós, Donát Péter; Minier, Tünde; Prohászka, Zoltán; Czirják, László; Varjú, Cecília

doi:10.1093/rheumatology/keu022

Cited by 33 publications

(33 citation statements)

References 19 publications

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“…Lippi et al demonstrated a strong, graded association of RDW with ESR and CRP in a large cohort of unselected outpatients [8]. In addition, RDW has also been correlated with disease activity or acute-phase reactants in several chronic inflammatory conditions such as inflammatory bowel disease, Behcet's disease, RA, and scleroderma [9][10][11][12][13]20].…”

Section: Discussionmentioning

confidence: 99%

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Red cell distribution width: a measure of cardiovascular risk in rheumatoid arthritis patients?

2015

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This study aims to evaluate if myocardial infarction (MI) is more frequent in rheumatoid arthritis (RA) patients with elevated levels of red cell distribution width (RDW). Utilizing a secure cloud based platform, Explorys, we searched de-identified US patient data between 1999 and 2014. RA patients were identified by serologic positivity and ICD9 diagnosis code. Patients were stratified into high (≥15.6 %) RDW and low (<13.5 %) RDW groups (and excluding any patient with prior episode of RDW >15.6 %). The proportion of patients with diagnosis of MI in each RDW group was collected. For comparison, patients were divided into high and low CRP groups (≥2.5 and ≤0.8 mg/dL) and high and low ESR groups (≥50 and ≤30 mm/h), and MI data were collected. Statistical comparison between high and low laboratory test groups was performed with chi-square test, and odds ratios were calculated. The patient population included 20,810 patients with RA. The proportion of RA patients with MI was significantly increased in the high compared to low RDW, ESR, and CRP groups (p < 0.001 for each). The odds ratios of MI were greater in the high than in the low group for each parameter: RDW (OR1.5, 95 % CI 1.3 to 1.6); ESR (OR2.0, 95 % CI 1.8-2.3); and CRP (OR1.9, 95 % CI 1.7 to 2.2). These data from a large unselected population suggest that elevated RDW levels in RA patients should prompt physicians to aggressively screen and treat their patients for modifiable cardiovascular (CVS) risk factors, in addition to treating RA inflammation.

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Section: Discussionmentioning

confidence: 99%

“…The apparent association between RDW and inflammation is strengthened by multiple studies demonstrating that RDW levels correlate with inflammatory markers and disease activity in several chronic inflammatory diseases [8][9][10][11][12][13]20].…”

Section: Introductionmentioning

confidence: 99%

Red cell distribution width: a measure of cardiovascular risk in rheumatoid arthritis patients?

2015

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“…In another study by Hassan et al [16], RDW level was found to be a useful parameter to show inflammation and high risk of progress. A high level of RDW also had a strong and independent correlation with ESR and CRP in systemic lupus erythematosis [17,18], Sjögren syndrome [19], systemic sclerosis [20], and familial mediterranean fever [21] patients in recent studies. RDW has also been found to be related to cardiovascular disease in various diseases [22].…”

Section: Discussionmentioning

confidence: 99%

The importance of red cell distribution width and neutrophil-lymphocyte ratio as a new biomarker in rheumatoid arthritis

Koca

Arslan

Özdemir

et al. 2019

The European Research Journal

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Objective: Rheumatoid arthritis (RA) is a long-lasting autoimmune disorder that primarily affects the joints. Various biomarkers have been used for the prognosis and clinical follow-up. There are few studies that have investigated whether or not neutrophil-lymphocyte ratio (NLR) and red cell distribution width (RDW) are good indicators of systemic inflammation. The present study aims to explore the prognostic value of RDW and NLR in rheumatoid arthritis (RA) as a new inflammatory marker. Methods: RA patients (n = 124) who presented to the Rheumatology outpatient clinic in our hospital between March 2015 and May 2015 were included in this study retrospectively. As a first group, 47 clinically active RA patients who had high acute phase proteins were included. In the second group, 73 clinically in-remission RA patients who had normal acute phase proteins were included. Fifty-five healthy volunteers constituted the control group. Results: The mean RDW was found to be 15.2 ± 2.9 in the active group; 14.6 ± 2 in the inactive group and 13.4 ± 1.4 in the control group (p < 0.01). The mean NLR was found to be 3.7 ± 2.2 in the active group; 3.7 ± 1.6 in the inactive group and 3.2 ± 0.9 in the control group (p = 0.190). There were statistically significant differences between the RDW values of the active-period RA patients with the control group (p < 0.01). There was statistically significant difference between RDW values of active RA and inactive RA patients (p < 0.01). The NLR results between the RA group and the control group (p = 0.700); the active RA group, and the inactive RA group (p = 0.169) were similar. There was not statistically difference between the NLR values of active RA patients with the control group (p = 0.360). There was statistically difference between the NLR values of inactive RA patients with the control group (p = 0.047). Conclusion: RDW was found higher in all RA group than control, additionally was also higher in active RA group than remission group. NLR values of remission group was higher than control.

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“…Markers of inflammation such as increased CRP and ESR level, which may signify increased disease activity and unfavorable prognosis. Several studies showed that the level of ESR was significantly higher in patients with diffuse SSc than in those with localized SSc 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Assessment of Neutrophil Lymphocyte Ratio in Systemic Sclerosis Patients in Tanta University Hospital: A Promising Marker in Predicting Disease Severity

Esheba¹,

Shahba²

2015

Egypt J of Rheumatol & Clinical Immunol

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Clinical usefulness of measuring red blood cell distribution width in patients with systemic sclerosis

Abstract: RDW in SSc may represent an integrative measure of multiple pathological processes including extensive vasculopathy, fibrosis or ongoing inflammation. An increase in RDW may indicate an impairment of cardiorespiratory function.

Cited by 33 publications

References 19 publications

Red cell distribution width: a measure of cardiovascular risk in rheumatoid arthritis patients?

Red cell distribution width: a measure of cardiovascular risk in rheumatoid arthritis patients?

The importance of red cell distribution width and neutrophil-lymphocyte ratio as a new biomarker in rheumatoid arthritis

Assessment of Neutrophil Lymphocyte Ratio in Systemic Sclerosis Patients in Tanta University Hospital: A Promising Marker in Predicting Disease Severity

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