Clinical usefulness of mean platelet volume and red blood cell distribution width to platelet ratio for predicting the severity of hepatic fibrosis in chronic hepatitis B virus patients

Abstract

MPV and RDW values are significantly higher in hepatitis B virus-infected patients, associated with severity, and can be defined as independent predicting factors in hepatic fibrosis. Further studies are required to determine the associations between MPV and the severity of fibrosis in hepatitis B patients.

Could mean platelet volume be a useful marker for infectious diseases? a review of literature

“…While there was no significiant difference in MPV levels between acute hepatitis B patients and healthy controls, higher MPV values in chronic hepatitis B patients compared with acute hepatitis B patients or healthy controls have been indicated [8,20]. Additionally, it has been reported that MPV can be defined as independent predicting factor in hepatic fibrosis [8].…”

“…Aside from their function in haemostasis, platelets have also a crurical role in the inflammatory response, and also their counts may change in parallel with the severity of infections [1][2][3][4][5][6][7][8][9][10][11]. In addition to changes in platelet counts during infections, platelet sizes can be altered by some factors such as platelet formation from megakaryocytes in response to thrombocytopenia or the release of platelet granules due to the activation of platelets [1][2][3][4].…”

“…myocardial infarction, ischemic stroke, mesenteric ischemia, deep vein trombosis, decompansated heart failure) or infectious diseases [e.g. sepsis, infective endocarditis, pneumonia, brucellosis, cellulitis, acute pyelonephritis (APN), ascites fluid infection (AFI), hepatitis B or hepatitis C] [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16].…”

Investigation of Mean Platelet Volume, Platelet Distribution Width and Erythrocyte Distribution Width in Patients with Hepatitis B Virus Infection

“…They declared that plateletderived indices may play a critical role in monitoring liver fibrosis and cirrhosis progression. Karagoz et al (13) found significantly high MPV and RDW values in HBV infected patients, and they declared that these parameters could be used in determining liver damage. In our study, there was no difference between the groups in terms of MPV and PDW values.…”

“…It is used in predicting the cause of anemia (12). New studies have declared that elevation of RDW values is associated with high mortality risk in different patient groups (13).…”