Clinical usefulness of high levels of C-reactive protein for diagnosing epithelial ovarian cancer

Abstract

The purpose of the present study was to evaluate the diagnostic role of CRP in ovarian cancer and to assess whether CRP can be combined with tumor markers to enhance the diagnostic efficacy toward ovarian cancer. Area under the curve, sensitivity, and specificity were calculated to access the diagnostic ability of each singly and combined as markers for ovarian cancer. The CRP cut-off value was then calculated to evaluate the diagnostic efficacy of CRP for ovarian cancer. Our results showed that values for all markers were significantly higher in the cancer group than in the control group. Receiver operating characteristic curve results showed that CA125 had the highest diagnostic efficacy for ovarian cancer, while the sensitivity for CRP was higher than for CA125, and the specificity for CRP was equal to that of CA125. The combination of CRP, CA125, and HE4, however, provided the strongest diagnostic capability. Furthermore, the diagnostic cut-off value for CRP with regard to ovarian cancer was 9.8 mg/L, and high levels of CRP were correlated with stage and tumor size of ovarian cancer. Our study indicated that CRP is valuable in the diagnosis of ovarian cancer, and that combining CRP with CA125 and HE4 improved the diagnostic efficacy with respect to ovarian cancer.

The Endometriotic Neoplasm Algorithm for Risk Assessment (e-NARA) Index Sheds Light on the Discrimination of Endometriosis-Associated Ovarian Cancer from Ovarian Endometrioma

“…A number of studies have demonstrated that inflammatory response factors are related to the survival of patients with cancer who have been surgically treated [ 59 , 60 , 61 , 62 , 63 ]. In the current study, inflammatory factors, such as elevated monocytes, platelets, and CRP, and decreased lymphocytes and albumin, showed good diagnostic efficacy at univariate analysis, which was comparable to previous reports [ 64 , 65 , 66 , 67 , 68 , 69 ]. Similar to the above malignant tumors, OE also induces severe inflammatory responses [ 70 , 71 , 72 ].…”

Influences of Gastrointestinal Microbiota Dysbiosis on Serum Proinflammatory Markers in Epithelial Ovarian Cancer Development and Progression

“…Preclinical models are proposed to understand possible mechanistic functions that may interlink these microorganisms with local and systemic inflammation during EOC development. C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) serum markers have shown to be higher in women with malignant ovarian tumors while there is uncertainty if serum levels are associated with unique GI microbes [ 27 , 28 , 29 , 30 ]. Thus, the purpose of this research was to explore the influences of GI microbiota dysbiosis on inflammatory markers during EOC development and progression using a mouse model.…”

The Utility of Pre-Treatment Inflammation Markers as Associative Factors to the Adverse Outcomes of Vulvar Cancer: A Study on Staging, Nodal Involvement, and Metastasis Models

“…The median CRP levels also increased as VC progressed (p = 0.005). An investigation in ovarian cancer cases [116] revealed a similar correlation between high CRP levels and tumour stage (p < 0.0001), suggesting inflammation happened in both cancers [117]. In bivariate analysis, we detected a significant correlation (OR 13.12, p = 0.015) between high CRP levels and the occurrence of DM (but not with LNM), which is consistent with findings in a previous study among patients with metastatic CRC [118].…”