Clinical usefulness of gastric-juice analysis in 2007: the stone that the builders rejected has become the cornerstone

Association between Increased Gastric Juice Acidity and Sliding Hiatal Hernia Development in Humans

“…Two reasons can justify the use of fasting gastric juice pH as an indicator of the degree of acid reflux to the esophagus, as well as of acid secretory function. Fasting gastric juice pH has been reported to correlate well with acid secretory function (basal acid output) [21]; hence, the present results directly explain the previous reports by Iwakiri et al [10], suggesting the correlation between hiatal hernia and hyperacidity predicted by endoscopic atrophy. Meanwhile, the lower esophagus is physiologically exposed to gastric acid even in normal subjects (normal range in a pH study for pH 4 holding time is within 8.42% in the supine position); thus, high gastric acid itself affects the environment of the gastroesophageal junction even without abnormal reflux [22].…”

Levels of malondialdehyde in the gastric juice: Its association with Helicobacter pylori infection and stomach diseases

“…MDA levels in serum and gastric mucosa increase significantly in patients with gastric cancer as compared with control subjects, and the positive correlation between MDA levels and gastric cancer has been proposed by previous studies. 6 In the present study, we demonstrated significantly higher gas- 23 Gastric juice provided a valuable source of pathophysiologic information for earlier and more accurate detection of stomach diseases than conventional exams by containing higher secreted factors from gastric mucosa.…”

“…1 As survival rate largely depends on the stage at the time of diagnosis, early detection of gastric cancer is crucial for curative treatment. [6][7][8] Gastric carcinogenesis is a complex process, and multiple factors, such as Helicobacter pylori (H. pylori), nutrition, lifestyle, genetic polymorphisms as well as environmental and epigenetic factors, have been proposed to interact with this multistep process. [3][4][5] Gastric juice, as a biologic sample, has been studied to reflect pathological changes in the stomach as well as disease progression.…”

Fundic gland polyps accurately predict a low risk of future gastric carcinogenesis

“…In our opinion, comparison of the acid secretory function and underlying gastric mucosa of subjects with FGPs and ''low risk'' subjects without FGPs provide a clue to more precisely understanding the characteristics of sporadic FGPs. The fasting gastric pH, a reliable indicator of gastric acid secretion [29], which thus correlates with atrophic grade, is statistically significantly lower in subjects with FGPs than those with ''low risk'' stomachs without FGPs. This finding suggests that the degree of gastric atrophy in subjects with FGPs is even milder than in those without FGPs among subjects with ''low risk'' stomachs.…”