Clinical usefulness of FDG–PET/CT for the evaluation of various types of adult T-cell leukemia

Nakachi, Sawako; Okada, Masahiro; Agarie, Yurika; Kitamura, Sakiko; Uchibori, Sachie; Tomori, Shouhei; Hanashiro, Taeko; Shimabukuro, Natsuki; Tamaki, Keita; Tedokon, Iori; Morichika, Kazuho; Nishi, Yusuke; Tomoyose, Takeaki; Karube, Kennosuke; Fukushima, Takuya; Murayama, Sadayuki; Masuzaki, Hiroaki

doi:10.1080/10245332.2017.1312088

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…Additionally, PET/CT helps predict the prognosis of ATLL. Nakachi et al demonstrated that the intensity of FDG uptake was significantly higher in the acute and lymphoma subtypes than in the smoldering and chronic subtypes (18). The prognosis of ATLL patients with breast involvement as an extranodal site has not been assessed because of the rarity of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…The monoclonal integration of HTLV-1 proviral DNA in the blood was confirmed by southern blotting. 18 F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) demonstrated an increased FDG uptake, not only in the skin nodules, but also in the bilateral breasts with standardized uptake values of 10.6 and 12.9, respectively (Fig. 1).…”

Section: Case Reportmentioning

confidence: 99%

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Adult T-cell Leukemia-lymphoma with Primary Breast Involvement: A Case Report and Literature Review

et al. 2020

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Breast involvement of Adult T-cell leukemia-lymphoma (ATLL) is extremely rare, and the data on the characteristics are limited. We herein describe a 49-year-old woman who presented with skin involvement of ATLL. Positron emission tomography/computed tomography showed bilateral breast lesions. Although the patient once achieved a complete metabolic response, a relapse of her ATLL occurred. The patient received subsequent allogeneic hematopoietic stem cell transplantation (HSCT). To our knowledge, only four cases of ATLL with breast involvement have previously been reported, and the prognoses have generally been poor. Breast lesions of ATLL have aggressive features, and intensive systemic chemotherapy and HSCT are required to improve survival.

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Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

Adult T-cell Leukemia-lymphoma with Primary Breast Involvement: A Case Report and Literature Review

et al. 2020

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“…However, it may indicate the limitation of evaluating treatment response only in terms of morphology. The previous study reported the clinical usefulness of FDG-PET for evaluating ATL; as such, FDG-PET may be able to predict whether ATL lesions will have tumor regrowth after RT [22].…”

Section: Discussionmentioning

confidence: 99%

Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lymphoma

Maemoto¹,

Ariga

Nakachi

et al. 2018

Journal of Radiation Research

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Adult T-cell leukemia/lymphoma (ATL) is an aggressive peripheral T-cell neoplasm that occurs only in patients with human T-cell leukemia virus type 1. No large study or randomized trial investigating radiotherapy (RT) for ATL has been performed. We retrospectively reviewed 55 courses of RT for 41 consecutive patients with ATL who underwent RT between 2000 and 2016 at our institutions. The results showed that RT for local ATL lesions can achieve symptomatic improvement in 92% of cases. Local remission, either complete remission (CR) or partial response (PR), was achieved in 100% of the patients (CR: 89%, PR: 11%) with ≥40 Gy irradiation. CR or PR was achieved in 71% (CR: 29%, PR: 43%) with 30-39 Gy and in 73% (CR: 6.7%, PR: 67%) with ≤29 Gy irradiation. The mean total radiation dose in the CR and PR groups differed significantly (38 vs 25 Gy, P = 0.0002). The maximum acute toxicity was Grade 0-2 in all patients, except for one patient experienced Grade 3 radiation dermatitis. In-field relapses occurred in 36% of patients, and the frequency of in-field relapses was 11%, 30% and 71% among those who achieved CR, PR and SD, respectively. All 9 patients who received total skin irradiation experienced cutaneous relapses, with a median of 63 days (range, 7-210 days). Almost all (39 of 41) patients with ATL experienced out-of-field progression after RT. In conclusion, RT was confirmed to be effective and safe for palliative treatment of local ATL lesions.

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“…Many studies have shown FDG-PET to be a powerful modality for assessing hematological malignancies and other neoplastic diseases [44][45][46][47]. In a retrospective study evaluating the utility of FDG-PET in diagnosing, staging, and restaging primary splenic lymphoma, 96.2% sensitivity, 91.7% specificity, and 94% accuracy were reported [48].…”

Section: Malignancymentioning

confidence: 99%

FDG-PET imaging to detect and characterize underlying causes of fever of unknown origin: an unavoidable path for the foreseeable future

Al-Zaghal

Raynor

Seraj

et al. 2018

Eur J Nucl Med Mol Imaging

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Clinical usefulness of FDG–PET/CT for the evaluation of various types of adult T-cell leukemia

Abstract: FDG-PET/CT findings could be useful for clinically grading ATL.

Cited by 10 publications

References 25 publications

Adult T-cell Leukemia-lymphoma with Primary Breast Involvement: A Case Report and Literature Review

Adult T-cell Leukemia-lymphoma with Primary Breast Involvement: A Case Report and Literature Review

Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lymphoma

FDG-PET imaging to detect and characterize underlying causes of fever of unknown origin: an unavoidable path for the foreseeable future

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