Clinical Use of Renal Perfusion Imaging by Means of Harmonic Sonography With a Microbubble Contrast Agent in Patients After Renal Transplantation

Eun, Hyo Won; Lee, Hun Jae; Goo, Dong Erk; Choi, Deuk Lin

doi:10.7863/jum.2005.24.6.755

Cited by 17 publications

(12 citation statements)

References 18 publications

(34 reference statements)

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“…Subsequent studies have been performed in rat (13,31,41), rabbit (59), dog (63,64,68), swine (24,69), mouse (55,57), and isolated organs (54). Contrast ultrasound imaging of the kidney is not in widespread clinical use, although studies have demonstrated potential utility for evaluation of focal abnormalities (46) and in identifying rejection following renal transplant (14,27,28). Of particular note, Kleinert et al (30) showed that TTP correlated to GFR in a small study of scleroderma patients, and Kalantarinia et al (26) demonstrated an increase cortical blood velocity in healthy subjects following a high-protein meal.…”

Section: Discussionmentioning

confidence: 99%

Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging

Declèves

Rychak

Smith

et al. 2013

American Journal of Physiology-Renal Physiology

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Declèves AE, Rychak JJ, Smith DJ, Sharma K. Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging. Am J Physiol Renal Physiol 305: F1343-F1351, 2013. First published September 18, 2013 doi:10.1152/ajprenal.00326.2013.-Obesity-related kidney disease occurs as a result of complex interactions between metabolic and hemodynamic effects. Changes in microvascular perfusion may play a major role in kidney disease; however, these changes are difficult to assess in vivo. Here, we used perfusion ultrasound imaging to evaluate cortical blood flow in a mouse model of high-fat diet-induced kidney disease. C57BL/6J mice were randomized to a standard diet (STD) or a high-fat diet (HFD) for 30 wk and then treated either with losartan or a placebo for an additional 6 wk. Noninvasive ultrasound perfusion imaging of the kidney was performed during infusion of a microbubble contrast agent. Blood flow within the microvasculature of the renal cortex and medulla was derived from imaging data. An increase in the time required to achieve full cortical perfusion was observed for HFD mice relative to STD. This was reversed following treatment with losartan. These data were concurrent with an increased glomerular filtration rate in HFD mice compared with STD-or HFD-losartan-treated mice. Losartan treatment also abrogated fibro-inflammatory disease, assessed by markers at the protein and messenger level. Finally, a reduction in capillary density was found in HFD mice, and this was reversed upon losartan treatment. This suggests that alterations in vascular density may be responsible for the elevated perfusion time observed by imaging. These data demonstrate that ultrasound contrast imaging is a robust and sensitive method for evaluating changes in renal microvascular perfusion and that cortical perfusion time may be a useful parameter for evaluating obesity-related renal disease. ultrasound contrast imaging; obesity-related kidney disease; renal perfusion THE GROWING EPIDEMIC OF OBESITY is a serious health and economic burden throughout the world. The consequence of obesity over time is characterized by insulin resistance, hyperglycemia, atherosclerosis, dyslipidemia, and hypertension. This cluster of risk factors referred to as metabolic syndrome occurs with 50% prevalence in patients 50-to 60-yr-old (4) and contributes to cardiovascular disease. Obesity is a major risk factor for diabetes and hypertension, which together account for ϳ70% of all cases of end-stage renal disease (6). However, there is growing evidence suggesting that obesity by itself may be an independent risk factor for the development of vascular dysfunction and renal disease (21,44,66). Obesity-related kidney disease occurs as a result of complex interactions between metabolic and hemodynamic factors and is characterized by changes of renal perfusion, vascular dysfunction, as well as albuminuria, glomerulosclerosis, and tubulointerstitial fibrosis (20,37,48,50). Alterations in blood flow within the cortex or the medulla ma...

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Section: Discussionmentioning

confidence: 99%

Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging

Declèves

Rychak

Smith

et al. 2013

American Journal of Physiology-Renal Physiology

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show abstract

“…In patients with renal artery stenosis (Fig. 10) or other vascular abnormalities, the re-filling curve revealed an increased time-to-peak and reduced slope of the wash-in tract and maximum amplitude [49, [67][68][69][70]. Animal models were initially employed to assess the capabilities of CEUS in the detection of renal perfusion defects [71][72][73][74][75], which appear as single or multiple focal wedge-shaped areas of absent, diminished or delayed contrast enhancement in comparison to the adjacent renal parenchyma (Figs.…”

Section: Clinical Applications Of Organ Perfusionmentioning

confidence: 99%

Assessment of tissue perfusion by contrast-enhanced ultrasound

Quaia

2010

Eur Radiol

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“…Renal perfusion imaging by means of harmonic ultrasonography with a microbubble contrast agent will potentially be very useful for the evaluation of renal perfusion in patients who have undergone renal transplantation; it shows not only the global perfusion status but also the focal perfusion defect in transplanted kidneys. 32 …”

Section: Ultrasonographically Guided Biopsymentioning

confidence: 99%

Complications of Renal Transplantation

Park

Kim

Cho

2007

Journal of Ultrasound in Medicine

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Objective. The purpose of this presentation is to show the ultrasonographic findings of complications of renal transplantation. Methods. We reviewed the ultrasonographic findings of complications of renal transplantation, including urologic complications, fluid collections, graft dysfunction, vascular complications, neoplasms, and recurrent native renal disease. Results. Specific ultrasonographic features of complications of renal transplantation have been illustrated. Conclusions. Familiarity with the clinical setting and the appearance of potential renal transplant complications as depicted with the most commonly used modality, ultrasonography, will facilitate prompt, accurate diagnosis and treatment.

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Clinical Use of Renal Perfusion Imaging by Means of Harmonic Sonography With a Microbubble Contrast Agent in Patients After Renal Transplantation

Abstract: The renal perfusion images obtained by means of harmonic sonography with a microbubble contrast agent constitute an effective sonographic technique for the evaluation of renal perfusion abnormalities after renal transplantation compared with a (99m)Tc-DTPA scan.

Cited by 17 publications

References 18 publications

Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging

Effects of high-fat diet and losartan on renal cortical blood flow using contrast ultrasound imaging

Assessment of tissue perfusion by contrast-enhanced ultrasound

Complications of Renal Transplantation

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