Clinical use of psychotomimetic drugs

Faillace, Louis A.

doi:10.1016/s0010-440x(66)80002-0

Cited by 10 publications

(5 citation statements)

References 36 publications

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“…In numerous studies—and this is particularly true for the Italian ones—the aim was primarily observational: the psychedelic was administered to the patients in order to observe the type of psychological reaction that they would evoke, rather than investigating the potential therapeutic effects. Louis Faillace called this approach “behaviorist” (Faillace, 1966: 16). This is distinct from the “physiological” approach, which aimed to study the pharmacological action of the drug, and from the “psychotherapeutic” approach, which assumes some therapeutic utility of the substance.…”

Section: Clinical Approaches With Psychedelicsmentioning

confidence: 99%

Italian psychedelic therapies of the past century: An historical overview

D’Arienzo

Samorini²

2023

Drug Science, Policy and Law

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In recent years, the historical record of psychedelic therapy in Europe and the Americas has undergone considerable revision. In this article, we contribute to this re-interpretation by sharing documentation relating to psychedelic therapy carried out in Italy during the period 1927–1966. Our library research has uncovered one hundred publications, documenting at least 60 clinical studies in which psychedelics were administered. There is evidence of some primacy regarding this psychedelic research: Italy has the world record, for the twentieth century, for having carried out the largest number of clinical studies on patients with psilocybin and with lysergic acid amide (LSA); humans first received the high dose of 500 mcg of lysergic acid diethylamide (LSD) in Italy; and LSD plus LSA, and LSD plus psilocybin, were administered simultaneously for the first time. The most successful Italian clinical studies appear to have been those in which psilocybin was used in the treatment of depressive states, with the observed optimal dose being that of 3 mg administered intravenously every second or third day, alternated with placebo injections. Another therapeutic target that seems to have provided interesting results concerns the use of LSD and psilocybin for what was then called “neurosis.” Italian psychiatrists have also made useful contributions to theoretical aspects concerning psychedelic therapies, for example in the conflicting debate on the “psychotomimetic paradigm” and in the distinction between the “primary” and “secondary” effects of these substances.

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Section: Clinical Approaches With Psychedelicsmentioning

confidence: 99%

Italian psychedelic therapies of the past century: An historical overview

D’Arienzo

Samorini²

2023

Drug Science, Policy and Law

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“…At that time, there were 2 different approaches to psychotherapy with LSD: "psycholytic" and "psychedelic" [38][39][40]. The psychedelic approach had its origin in North America, whereas psycholytic therapy was more commonly employed in Europe.…”

Section: Treatment Of Alcoholism and Addictionmentioning

confidence: 99%

The History of Psychedelics in Psychiatry

Nichols

Walter

2020

Pharmacopsychiatry

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Initial interest in the value of psychedelic drugs (“psychotomimetics”) in psychiatry began in the early 20th century, with explorations of the possibility that mescaline or peyote could produce psychosis-like effects. Over time, interest was focused on whether the effects of psychedelics could inform as to the underlying basis for psychiatric disorders. As research continued, and especially after the discovery of LSD in 1943, increasing interest in a role for psychedelics as adjuncts to psychotherapy began to evolve and became the major focus of work with psychedelics up to the present day.

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“…There are the social issues involved in repeated resort to the drugs, and the occasional adverse psychological responses to the drugs such as a prolonged mental disturbance or an acute distress which has led to suicide (Faillace, 1966). Recently some evidence has been discovered to show that LSD and related drugs may alter chromosomal structure, a potentially sinister finding (Lancet, 1967).…”

Section: Psychotomimetic Drugsmentioning

confidence: 99%

Psychotropic drugs.

Hinton

1968

Postgraduate Medical Journal

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Clinical use of psychotomimetic drugs

Cited by 10 publications

References 36 publications

Italian psychedelic therapies of the past century: An historical overview

Italian psychedelic therapies of the past century: An historical overview

The History of Psychedelics in Psychiatry

Psychotropic drugs.

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