Clinical Use of Paraprobiotics for Pregnant Women with Periodontitis: Randomized Clinical Trial

Abstract

Periodontal disease is very common in pregnant women. Paraprobiotics are a subset of probiotics. They can be defined as inactivated microbial cells providing health benefits to the host and are considered particularly safe. The aim of this study was to compare the periodontal health of pregnant women and puerperae after 6 months of home use of paraprobiotics. A total of 30 pregnant women were enrolled and divided into two groups: the test group, who had to use a paraprobiotic-based toothpaste (Biorepair Peribioma Pro, Coswell S.p.A., Funo di Argelato, BO, Italy) and mousse (Mousse Mouthwash Biorepair Peribioma, Coswell S.p.A.) twice a day, and the control group, who had to use only the paraprobiotic-based toothpaste. The time frames of the study were: 1 month (T1), 3 months (T2) and 6 months (T3), and data were collected during pregnancy and in the period immediately following delivery. The following indices were evaluated at T0, T1, T2 and T3: clinical attachment loss (CAL), probing pocket depth (PPD), bleeding on probing (BOP), plaque control record (PCR), modified marginal gingival index (mMGI), papillary marginal gingival index (PMGI) and recessions (R). All data were subjected to statistical analysis. PCR decreased significantly from T0 to T1 in the control group and from T0 to T2 and from T0 to T3 in the test group. BOP tended to decrease in both groups, but a significant reduction was observed only in the test group. CAL, PPD, PMGI and mMGI tended to decrease gradually in both groups without significant differences between or within groups. The combination of the paraprobiotic-based toothpaste and the paraprobiotic-based mousse significantly reduced BoP and plaque control over time, although there were no significant differences with the use of the paraprobiotic-based toothpaste alone. In addition, the combination of the two products promoted a trend towards the better stabilization of recessions.

Bibliometric Network Analysis and Visualization of Research Trends in Gingivectomy

“…The summary Table 4 presents the top ten journals with their respective publication numbers. Topping the list is the Journal of Periodontology, with 36 publications, followed by the Journal of the Indian Society of Periodontology (28) and Dentistry Today (22). The list concludes with the Journal of Oral and Maxillofacial Surgery and Contemporary Clinical Dentistry, each contributing 12 This concise presentation provides a clear overview of the significant contributors in gingivectomy research journals.…”

“…Leading with over 30 publications, the Journal of Periodontology stands out, followed by the Journal of The Indian Society of Periodontology (28) and Dentistry Today (22). The analysis transitions from quantity to quality, evaluating journals using Scimago Journal & Country Rank (SJR) incorporating factors like Quartile, H-Index, SJR, and citation frequency.…”

“…Third, Additionally, it should be considered that other recently introduced compounds have been demonstrated to have a significant influence on the oral environment. The use of postbiotics, 21 lysates 22 and Paraprobiotics 23 can modify Clinical Parameters in periodontal patients, so also these products should be considered in future research, as adjuvants, for gingivectomy procedures. Therefore, future reports are needed to consider these emerging compounds in combination with this well-known surgical technique.…”

Platelet-Rich Plasma (PRP) and Injectable Platelet-Rich Fibrin (i-PRF) in the Non-Surgical Treatment of Periodontitis—A Systematic Review

“…Currently, a minimally invasive approach involving proactive procedures is preferred. Probiotics as well as paraprobiotics used in adjunctive therapy are effective for reducing the bacterial load [ 10 , 11 , 12 ]. The maintenance of periodontal health is dependent upon the control of plaque [ 13 , 14 , 15 ].…”