Clinical use of organic near‐infrared fluorescent contrast agents in image‐guided oncologic procedures and its potential in veterinary oncology

Favril, Sophie; Abma, Eline; Blasi, Francesco; Stock, Emmelie; Devriendt, Nausikaa; Vanderperren, Katrien; Rooster, H. de

doi:10.1136/vr.104851

Cited by 19 publications

(29 citation statements)

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“…Better diagnostic accuracy and more extensive fluorescent‐guided cytoreductive surgery were recently described in human patients with peritoneal carcinomatosis after fluorescent contrast administration 24‐26 . A combination of different diagnostic and therapeutic options might prove valuable in the future by using already existing techniques such as fluorescence imaging for both sentinel lymph node mapping 27 and carcinomatosis detection. Although the carcinomatosis was observed only after the RARP, it is impossible to trace whether this unwanted outcome was triggered by the surgery or not.…”

Section: Discussionmentioning

confidence: 99%

First robot‐assisted radical prostatectomy in a client‐owned Bernese mountain dog with prostatic adenocarcinoma

et al. 2020

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Objective: To describe robot-assisted radical prostatectomy (RARP) and report the short-term outcome of a dog with prostatic cancer treated with RARP. Study design: Case report Animals: Client-owned 6-year-old male-neutered Bernese mountain dog. Methods: Robot-assisted radical prostatectomy was performed with a daVinci Si Surgical System through a transperitoneal approach. An interfascial nervesparing approach was used to preserve the neurovascular bundles and increase the likelihood of postoperative urinary continence. Urinary continence was assessed by placing white cloth bedding in the kennel during hospitalization and by owners' observation at home. Results: The console time was 120 minutes, and the estimated intraoperative blood loss was 30 mL. No intraoperative complications were observed. The urinary catheter was removed after 7 days, at which point the dog urinated normally. Peritoneal carcinomatosis was diagnosed 43 days after surgery, and the dog was euthanized. Conclusion: Robot-assisted radical prostatectomy was successfully completed in a dog with prostatic neoplasia and led to postoperative urinary continence. Clinical significance: This single-case report provides evidence to justify further evaluation of RARP in dogs with prostatic neoplasms. 1 | INTRODUCTION Prostatic cancer has a prevalence of 0.2% to 0.6% in the domestic dog population and affects 13% of dogs with prostatic disease. 1,2 No effective curative treatment modality currently exists. A much longer median survival time was described in dogs with prostatic carcinoma receiving cyclooxygenase (COX) inhibitors vs dogs not receiving any treatment (6.9 vs 0.7 months) in one retrospective study. 3 Whereas treatment effect is indisputable because of the over expression of COX-2 in canine prostatic carcinoma cells, 3 the difference in survival times in that study was most likely biased because there was no randomization in treatment groups. Information on the role of radiation therapy for canine prostatic carcinoma in the veterinary literature remains scarce. In a study in A. Schlake and P. Dell'Oglio share first authorship.

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Section: Discussionmentioning

confidence: 99%

First robot‐assisted radical prostatectomy in a client‐owned Bernese mountain dog with prostatic adenocarcinoma

et al. 2020

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“…Various methods of preoperative and intraoperative SLN mapping have been described including lymphoscintigraphy, 9,22,23 injection of vital dyes such as methylene blue, isosulfan blue, or patent blue violet, 5,9,15,[23][24][25][26] contrast enhanced ultrasonography, 27,28 nearinfrared florescent imaging, 5,28,29 lipid soluble iodinated contrast medium with radiography or CT, 15,18,30,31 and water soluble iodinated contrast medium (WIC) with CT. 16,17,19,20,31 The most common and current gold standard modality for SLN mapping in both human and veterinary oncology is lymphoscintigraphy that uses a radiolabeled colloid injected subcutaneously around the primary tumor site followed by assessment of the movement of radioactive particles through the lymphatic drainage system using a gamma camera. Unfortunately, lymphoscintigraphy is costly and requires special licensure for the use of a radioactive isotope and specialized equipment that limits availability of this diagnostic technique to referral centers.…”

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Sentinel lymph node detection differs when comparing lymphoscintigraphy to lymphography using water soluble iodinated contrast medium and digital radiography in dogs

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et al. 2020

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Sentinel lymph node (SLN) mapping by various means has become standard of care in certain types of human cancers and is receiving more attention in veterinary oncology. Current SLN mapping techniques can be costly and often require advanced imaging equipment. The objective of this prospective, method comparison study was to compare an SLN mapping protocol of lymphoscintigraphy to lymphography using water soluble iodinated contrast medium (WIC) and digital radiography for identification of an SLN. Lymphoscintigraphy and lymphography were performed on eight healthy purpose-bred dogs using technetium-99m sulfur colloid and WIC injected into the subcutaneous tissues in a four-quadrant technique around a predefined area of skin on the brachium. Images were obtained using a gamma camera and digital radiography at different time points post-injection. Image sequences were evaluated by one of two American College of Veterinary Radiology board-certified veterinary radiologists. Data obtained were compared between methods using descriptive statistics. An SLN was identified in all dogs with lymphoscintigraphy and seven of eight dogs with lymphography. Agreement between results of the lymphoscintigraphy and lymphography studies was a complete match in three dogs, a partial match in four dogs, and no match in one dog. The SLN detected differed based on the imaging modality used.

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“…Near-infrared fluorescence (NIRF) imaging is a relatively novel technology that has been shown effective during tumour resection. [18][19][20][21][22][23] Visible light only penetrates a few hundred micrometers into blood and tissue and provides only information of the surface features of the surgical field. The nearinfrared window (700-950 nm) lies outside the human visible wavelength range 24 and allows deep tissue imaging (up to 15 mm 16 19 25 26 ).…”

Section: Introductionmentioning

confidence: 99%

“…The near‐infrared window (700–950 nm) lies outside the human visible wavelength range24 and allows deep tissue imaging (up to 15 mm16 19 25 26). Intraoperative tumour detection and margin assessment is one of the most promising applications of the NIRF technology,23 since it may increase the likelihood of complete eradication of tumour tissue and thus reduce the risk of tumour recurrence.…”

Section: Introductionmentioning

confidence: 99%

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Fluorescence‐guided surgery using indocyanine green in dogs with superficial solid tumours

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BackgroundNear-infrared fluorescence (NIRF) imaging is a relatively novel technique that can aid surgeons during intraoperative tumour identification.MethodsNine canine oncology patients (five mammary gland tumours, three mast cell tumours and one melanoma) received intravenous indocyanine green (ICG). After 24 hours, tumours were resected and fluorescence intensities of tumours and surroundings were evaluated. Additional wound bed tissue was resected if residual fluorescence was present after tumour resection. Ex vivo, fluorescence-guided dissection was performed to separate tumour from surrounding tissue.ResultsIntraoperative NIRF-guided tumour delineation was feasible in four out of nine dogs. Wound bed imaging after tumour removal identified nine additional fluorescent lesions, of which four contained tumour tissue. One of these four true positive in vivo lesions was missed by standard-of-care inspection. Ex vivo fluorescence-guided tumour dissection showed a sensitivity of 72 per cent and a specificity of 80 per cent in discriminating between tumour and surrounding tissue.ConclusionThe value of ICG for intraoperative tumour delineation seems more limited than originally thought. Although NIRF imaging using ICG did identify remaining tumour tissue in the wound bed, a high false positive rate was also observed.

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Clinical use of organic near‐infrared fluorescent contrast agents in image‐guided oncologic procedures and its potential in veterinary oncology

Cited by 19 publications

References 103 publications

First robot‐assisted radical prostatectomy in a client‐owned Bernese mountain dog with prostatic adenocarcinoma

First robot‐assisted radical prostatectomy in a client‐owned Bernese mountain dog with prostatic adenocarcinoma

Sentinel lymph node detection differs when comparing lymphoscintigraphy to lymphography using water soluble iodinated contrast medium and digital radiography in dogs

Fluorescence‐guided surgery using indocyanine green in dogs with superficial solid tumours

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