Clinical use of direct oral anticoagulants in modern practice. Efficiency and safety

Abstract

The article considers clinical and pharmacological approaches to rational pharmacotherapy with direct oral anticoagulants (DOAC). The main issues of the mechanism of action, pharmacodynamics, and interaction of these medicines, as well as adverse reactions and, consequently, risks associated with taking DOAC, and the principles of selecting direct oral anticoagulants are discussed. The materials are presented on the basis of modern data from domestic and foreign literature.