Clinical Use of a New Synthetic Penicillin: Pa-248

Nagley, M.M.

doi:10.1016/s0140-6736(61)90176-3

Cited by 6 publications

(2 citation statements)

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“…The compounds 40 and 41 are administered as racemic mixtures. The phenoxyacetamides are more acid resistant and are adsorbed about four times more efficient from the stomach [ 63 , 64 ]. The presence of an oxygen atom β to the carbonyl group makes the side chain carbonyl much less electrophilic and prevented reaction with the lactam carbonyl in acidic media [ 38 , 42 ].…”

Section: β-Lactamsmentioning

confidence: 99%

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Drugs That Changed Society: History and Current Status of the Early Antibiotics: Salvarsan, Sulfonamides, and β-Lactams

Christensen

2021

Molecules

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The appearance of antibiotic drugs revolutionized the possibilities for treatment of diseases with high mortality such as pneumonia, sepsis, plaque, diphtheria, tetanus, typhoid fever, and tuberculosis. Today fewer than 1% of mortalities in high income countries are caused by diseases caused by bacteria. However, it should be recalled that the antibiotics were introduced in parallel with sanitation including sewerage, piped drinking water, high standard of living and improved understanding of the connection between food and health. Development of salvarsan, sulfonamides, and β-lactams into efficient drugs is described. The effects on life expectancy and life quality of these new drugs are indicated.

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Section: β-Lactamsmentioning

confidence: 99%

“… Semisynthetic penicillins. Phenoxyacyl penicillins: phenoxymethyl penicillin/penicillin V (Vepicombin, 39 ), phenoxyethyl penicillin (phenithicillin, 40 ), Phenoxypropylpenicillin ( 41 ) [ 63 , 64 ]. Aminoacylpenicillins ampicillin ( 42 ), epicillin ( 43 ), amoxicillin ( 44 ) and cyclacillin ( 45 ).…”

Section: Figures Schemes and Tablementioning

confidence: 99%