Clinical Use of A.F.P. And H.C.G. In Testicular Tumours of Germ-Cell Origin

Nørgaard‐Pedersen, Bent; Albrechtsen, Reidar; Bagshawe, K. D.; Buffe, D; Endo, Yuki; Heyderman, Eadie; Hirai, Hiroshi; Horne, C. H. W.; Hägerstrand, Inga; Javadpour, Nasser; Knudsen, J.B.; Kohn, J.; Lamerz, R.; Lange, Paul H.; McIntire, K. Robert; Neville, A. Munro; Nustad, Kjell; Peckham, M. J.; Ratcliffe, John G.; C, Rimbaut; Rosen, Saul W.; Sakashita, Shigeo; Scardino, P.T.; Schultz, Henrik; Seppälä, Mika; Sizaret, P; Talerman, A.; Thompson, D.K.; Tsuchida, Junji; Vaitukaitis, Judith L.; Wahrén, Britta; Waldmann, Thomas A.

doi:10.1016/s0140-6736(78)92355-3

Cited by 16 publications

(2 citation statements)

References 2 publications

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“…Teratomas belongs to NSGCTs and can be classified into malignant immature solid lesions and benign mature cystic lesions ( 42 ). AFP is an important marker for the clinical differentiation between benign teratomas (within the normal range) and malignant teratomas (higher than the normal range) ( 43 ). Nevertheless, Caposole et al.…”

Section: Gynecological and Obstetric Diseasesmentioning

confidence: 99%

Beyond liver cancer, more application scenarios for alpha-fetoprotein in clinical practice

Ma,

Jin,

Wang

et al. 2023

Front. Oncol.

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Alpha-fetoprotein (AFP) is a commonly used clinical biomarker. Before 1970, the two-way agar diffusion method was mainly used, and the specificity of AFP in the diagnosis of primary liver cancer was satisfactory. However, its positivity rate was not very high. The diagnostic value of AFP is changing with the evolution of detection methods. Here, we performed a literature search to identify English-language publications. The search was performed from January 2015 to April 2023 using the PubMed database and the following terms in [Titles/Abstracts]: alpha-fetoprotein, clinical practice, detection, etc. The references of retrieved articles were also screened to broaden the search. Studies referring to liver cancer and AFP detection methods were excluded. In this review, several clinical application scenarios for AFP were systematically reviewed, and its potential detection value in the future was discussed.

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Section: Gynecological and Obstetric Diseasesmentioning

confidence: 99%

Beyond liver cancer, more application scenarios for alpha-fetoprotein in clinical practice

Ma,

Jin,

Wang

et al. 2023

Front. Oncol.

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“…hCG is also produced in tumors derived from trophoblasts and germ cell tumors containing syncytiotrophoblastic elements [1][2][3][4][5][6]. Ectopic production of hCG, its P-subunit (P-hCG) or hCG-like material (hCG-1) has been demonstrated for variety of nongonadal tumors with or without some degree of trophoblastic differentia tion [1,[7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22], In some of these tumors there have been indications of a prognostic significance of this production [6][7][8].…”

Section: Introductionmentioning

confidence: 99%

Association of Testicular Non-Hodgkin’s Lymphomas with Elevated Serum Levels of Human Chorionic Gonadotropin-Like Material

Møller

1996

Oncology

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Serum β-human chorionic gonadotropin (S-β-hCG) is a widely used tumor marker in patients with testicular neoplasia. When elevated in patients with an enlarged testis it is considered as a strong indication of a germ cell tumor. Elevation of S-hCG-like material (S-hCG-1) has been reported in nontesticular non-germ cell tumors including non-Hodgkin’s lymphomas (NHL) as well. It has never been investigated whether testicular NHL is also associated with elevated S-hCG-1. In the present study the relationship of testicular NHL with increased S-hCG-1 was investigated. In the Danish population-based NHL registry, LYFO registry, 12 cases with testicular involvement of the lymphoma at the time of diagnosis and that had S-hCG-1 measured prior to treatment were identified, and cases with elevated S-hCG-1 were analyzed clinicopatho-logically. Of these, 2 patients had elevated levels. Both cases were high-grade, diffuse B-cell NHL in elderly patients. The patients were hemiorchiectomized and after surgery levels of S-hCG-1 declined to normal. The study indicates that S-hCG-1 elevation is quite frequently associated with testicular NHL. The prognostic significance of this elevation remains to be investigated, as does the usefulness of S-hCG-1 as tumor marker for early detection of recurrences and for monitoring the therapy of patients with S-hCG-1-positive NHL.

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Pathology of Germ Cell Tumors of Testis

Mostofi

1980

Cancer

184

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Since the last National Conference on Urological Tumors, there has been major progress in pathology of testicular tumors. An international histological classification of these tumors has been proposed, which is based on the sound principle that pathological examination must specify the exact components that are present in a tumor and give an estimate of relative proportions of each. The WHO classification, using generally accepted principles of tumor typing, has provided a standard method of pathological reporting of these tumors so that results of research from different parts of the world can be compared. The WHO system published in 1977 is readily convertible to the system in use in the American Testicular Tumor Registry. Its convertibility to the Friedman-Moore and Pugh-Cameron Testicular Tumor classifications is limited. Though it is generally believed that embryonal carcinoma can differentiate along extra-embryonic lines to form yolk sac tumor and choriocarcinoma or along embryonic lines to form teratoma, the malignant germ cell itself seems to have the potential to develop along any of these lines without first going through the embryonal carcinoma phase. Seminomas with high mitotic index and seminomas that contain syncytiotrophoblasts appear to have a less favorable prognosis than classic seminomas or spermatocytic seminomas. HCG is readily demonstrable in syncytiotrophoblasts whether alone or forming choriocarcinoma. AFP is demonstrable in yolk sac tumors and in some embryonal carcinomas. Histological demonstration of AFP and HCG can and should be correlated with clinical findings. Such correlation can readily be made with the WHO histological classification of these tumors.

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Clinical Use of A.F.P. And H.C.G. In Testicular Tumours of Germ-Cell Origin

Cited by 16 publications

References 2 publications

Beyond liver cancer, more application scenarios for alpha-fetoprotein in clinical practice

Beyond liver cancer, more application scenarios for alpha-fetoprotein in clinical practice

Association of Testicular Non-Hodgkin’s Lymphomas with Elevated Serum Levels of Human Chorionic Gonadotropin-Like Material

Pathology of Germ Cell Tumors of Testis

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