Clinical Update: Why PRP Should Be Your First Choice for Injection Therapy in Treating Osteoarthritis of the Knee

Cook, Corey S.; Smith, Patrick A.

doi:10.1007/s12178-018-9524-x

Cited by 104 publications

(143 citation statements)

References 112 publications

(126 reference statements)

Supporting

Mentioning

131

Contrasting

Unclassified

Order By: Relevance

“…Some studies have estimated that up to 25% of patients receiving TKAs were inappropriately provided with this treatment [15,[25][26][27][28]. Furthermore, up to one third of patients continue to experience chronic knee pain after TKA [29]. Arthroscopy is another common treatment for treating K-OA; however, it remains controversial with some authors showing it to only provide transient, inconsequential benefit with an unacceptably high risk of adverse events [30].…”

Section: The Scope Of the Problemmentioning

confidence: 99%

“…Synovial fluid, produced by the synovial membrane, lubricates the joint and provides the avascular cartilage with nutrients. Treatment of OA can be hampered by the avascular and aneural nature of the knee joint cartilage [29]. K-OA is typically classified as either primary/idiopathic or secondary due to trauma or misalignment.…”

Section: Knee Anatomymentioning

confidence: 99%

“…Also, there may also be progression of the K-OA, with a 2017 RCT determining that intra-articular injection with triamcinolone resulted in greater cartilage volume loss when compared to intra-articular saline injection at two years [41]. Systemic side effects of corticosteroids include elevated blood pressure, hyperglycemia, and alterations in mood and energy [29]. Triamcinolone, which is less water soluble than methylprednisolone, may be a better alternative for those with diabetes and in whom the risk of postinjection hyperglycemic spikes should be minimized [40].…”

Section: Corticosteroid Injectionsmentioning

confidence: 99%

“…PRP is autologous plasma that has been prepared to contain a higher concentration of platelets than in vivo plasma. While there is no standardized concentration of platelets in PRP, it is generally accepted that it should contain somewhere between 2 and 8 times the concentration of platelets as autologous serum [29,35]. When platelets are activated, they rapidly release numerous growth factors, such as TGF-β and IGF-1, from their α-granules [55].…”

Section: Platelet-rich Plasmamentioning

confidence: 99%

See 3 more Smart Citations

Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies

Billesberger¹,

Fisher

Qadri

et al. 2020

Pain Research and Management

View full text Add to dashboard Cite

Knee osteoarthritis is a common painful degenerative condition affecting the aging Canadian population. In addition to pain and disability, osteoarthritis is associated with depression, comorbid conditions such as diabetes, and increased caregiver burden. It is predicted to cost the Canadian healthcare system $7.6 billion dollars by 2031. Despite its high cost and prevalence, controversy persists in the medical community regarding optimal therapies to treat knee osteoarthritis. A variety of medications like nonsteroidal anti-inflammatories and opioids can cause severe side effects with limited benefits. Total knee arthroplasty, although a definitive management, comes with risk such as postoperative infections, revisions, and chronic pain. Newer injectable therapies are gaining attention as alternatives to medications because of a safer side effect profile and are much less invasive than a joint replacement. Platelet-rich plasma is beginning to replace the more common injectable therapies of intra-articular corticosteroids and hyaluronic acid, but larger trials are needed to confirm this effect. Small studies have examined prolotherapy and stem cell therapy and demonstrate some benefits. Trials involving genicular nerve block procedures have been successful. As treatments evolve, injectable therapies may offer a safe and effective pathway for patients suffering from knee osteoarthritis.

show abstract

Section: The Scope Of the Problemmentioning

confidence: 99%

Section: Knee Anatomymentioning

confidence: 99%

Section: Corticosteroid Injectionsmentioning

confidence: 99%

Section: Platelet-rich Plasmamentioning

confidence: 99%

See 2 more Smart Citations

Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies

Billesberger¹,

Fisher

Qadri

et al. 2020

Pain Research and Management

View full text Add to dashboard Cite

show abstract

“…19,20 Because various methods exist to create different platelet-derived orthobiologics, we define platelet-rich plasma (PRP) as any product in which the concentration of platelets is increased relative to whole blood and partially or fully isolated from leukocytes and red cells within a plasma medium. 15,[20][21][22] More recently, the use of platelet-rich products has been shown to help alleviate pain and/or improve function including objective gait analysis in dogs with both naturally occurring and experimental models of OA. [13][14][15][16]23 We hypothesized that a single intra-articular injection of pure PRP (no white or red cells within the product) into the more severely affected stifle would cause substantial positive changes in kinetic gait symmetry in dogs with unilateral or bilateral chronic osteoarthritis attributed to long-term (>12 months) naturally occurring cranial cruciate ligament disease.…”

Section: Introductionmentioning

confidence: 99%

<p>Assessment of a Single Intra-Articular Stifle Injection of Pure Platelet Rich Plasma on Symmetry Indices in Dogs with Unilateral or Bilateral Stifle Osteoarthritis from Long-Term Medically Managed Cranial Cruciate Ligament Disease</p>

Venator¹,

Frye²,

Gamble³

et al. 2020

VMRR

View full text Add to dashboard Cite

These authors contributed equally to this workPurpose: The use of platelet-rich plasma (PRP) to treat canine osteoarthritis has gained support within the scientific community. PRP effects on pain control for degenerative joint disease induced by naturally occurring cranial cruciate ligament instability are limited, particularly in a cohort of dogs with chronic instability and osteoarthritis (>12 months), representing a commonly encountered clinical population that often defaults to medical management. The goal of this study was to assess the effects of a single intra-articular PRP injection into an effected stifle in this cohort, to assess response to treatment, quantitative kinetic data as it relates to percent body weight for peak vertical force (PVF) and vertical impulse (VI) were collected, and symmetry indices related to PVF were determined. Methods: Twelve dogs with unilateral or bilateral osteoarthritis with ruptured, nonstabilized cranial cruciate ligaments over 12 months duration were identified. Unilateral injections of 2.5 mL of a PRP preparation into the most severely affected stifle based on kinetic analysis was performed. Repeat pressure-sensitive walkway analysis was conducted monthly for 3 months. Peak vertical force (PVF) and vertical impulse (VI) were normalized to body weight and identified in all four limbs. Previously published symmetry indices regarding PVF were calculated, comparing the treated limb with the contralateral limb, ipsilateral forelimb, and contralateral forelimb. Results: After treatment, hind limb symmetry index (SI) regarding PVF showed improved symmetry, suggesting more weight placement at all-time points after injection of the most affected limb (p < 0.01). Further, PVF asymmetry indices assessing contralateral fore (CFL) and hind limb (CHL) as well as ipsilateral forelimb (IFL) revealing a significant decrease from baseline for CHL at week 4 (p = 0.02), but not weeks 8 and 12. The CFL showed decreased differences in symmetry from baseline at each time point (p = 0.03). There were no statistically significant changes in PVF or VI over time in treated dogs. Conclusion: A single injection of PRP improved kinetics for minimally 4 weeks with some data suggesting an effect for up to 12 weeks. Therefore, PRP might be a viable therapeutic option for instability and inflammation associated with chronic osteoarthritis due to cranial cruciate ligament disease in the non-surgical patient.

show abstract

Biomaterial Integration in the Joint: Pathological Considerations, Immunomodulation, and the Extracellular Matrix

Mentzer

Corciulo

Stubelius

2022

Macromolecular Bioscience

View full text Add to dashboard Cite

Defects of articular joints are becoming an increasing societal burden due to a persistent increase in obesity and aging. For some patients suffering from cartilage erosion, joint replacement is the final option to regain proper motion and limit pain. Extensive research has been undertaken to identify novel strategies enabling earlier intervention to promote regeneration and cartilage healing. With the introduction of decellularized extracellular matrix (dECM), researchers have tapped into the potential for increased tissue regeneration by designing biomaterials with inherent biochemical and immunomodulatory signals. Compared to conventional and synthetic materials, dECM‐based materials invoke a reduced foreign body response. It is therefore highly beneficial to understand the interplay of how these native tissue‐based materials initiate a favorable remodeling process by the immune system. Yet, such an understanding also demands increasing considerations of the pathological environment and remodeling processes, especially for materials designed for early disease intervention. This knowledge will avoid rejection and help predict complications in conditions with inflammatory components such as arthritides. This review outlines general issues facing biomaterial integration and emphasizes the importance of tissue‐derived macromolecular components in regulating essential homeostatic, immunological, and pathological processes to increase biomaterial integration for patients suffering from joint degenerative diseases.

show abstract

Clinical Update: Why PRP Should Be Your First Choice for Injection Therapy in Treating Osteoarthritis of the Knee

Cited by 104 publications

References 112 publications

Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies

Procedural Treatments for Knee Osteoarthritis: A Review of Current Injectable Therapies

<p>Assessment of a Single Intra-Articular Stifle Injection of Pure Platelet Rich Plasma on Symmetry Indices in Dogs with Unilateral or Bilateral Stifle Osteoarthritis from Long-Term Medically Managed Cranial Cruciate Ligament Disease</p>

Biomaterial Integration in the Joint: Pathological Considerations, Immunomodulation, and the Extracellular Matrix

Contact Info

Product

Resources

About