Clinical Trials of Nonane in Malignant Disease

The sensitivity of a yoshida sarcoma to methylene dimethane sulphonate

“…1) is the first member of a homologous series of which Busulphan (Fig. 1, n-4) (Haddow and Timmis, 1953) and Nonane (n-9) (Miller, 1961) are wellknown anti-tumour alkane sulphonates employed clinically. The series from n =2 to n = 18 has been investigated in some detail (Carlson and Morgan, 1954;Ross, 1962) and some of the chemical (Emmons and Ferris, 1953) and biological (Fox and Jackson, 1965;James, 1966;Crystal, 1968) properties of the methylene derivative (n= 1) have also been reported.…”