Clinical trials of diamidine in Rhodesian sleeping sickness

T, Ogada; Fink, E; Mbwabi, D.

doi:10.1016/0035-9203(73)90197-1

Cited by 10 publications

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“…Berenil (diminazene aceturate B. vet C) is widely used in Africa, primarily for the treatment of Trypanosoma congolense and 7: vivax infections of livestock (Williamson 1970;Holmes & Scott 1982). It has also been shown to have some values in the treatment of T gambiense and T rhodesiense infections, the human sleeping sickness, especially at the early stages of infection when the parasites are confined to the blood stream (Bailey 1968;Ogada et al 1973).…”

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Effect of Repeated Administration of Berenil on Urinary Enzyme Excretion with Corresponding Tissue Pattern in Rats

Akanji

Ngaha

1989

Pharmacology & Toxicology

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The effect of repeated administration of berenil, a trypanocide, on urinary excretion of some enzyme activities in rat and their corresponding levels in the kidney and serum was investigated. Daily administration of this drug to rats resulted in increased urinary volume, excretion of protein, alkaline phosphatase and lactate dehydrogenase activities. However, the level of acid phosphatase activity was not significantly increased while muramidase activity disappeared completely during the period of drug administration. In the kidney tissue, there was a significant loss of lactate dehydrogenase activity immediately after the first dose and this trend continued until the end of drug administration. In the same tissue, there was an increase in alkaline phosphatase activity while the lysosomal enzymes were not significantly affected. In the serum, except for the increase in alkaline phosphatase activity, all other enzymes were not significantly affected. All these results indicate that there is cellular damage to rat kidney as a result of repeated berenil administration, and that the plasma membrane and the soluble portion of the cytoplasm are the primary site of injury to the cells. They also suggest that urinary enzyme excretion could be useful in determining the site of cellular damage by chemical agents in kidneys.

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Effect of Repeated Administration of Berenil on Urinary Enzyme Excretion with Corresponding Tissue Pattern in Rats

Akanji

Ngaha

1989

Pharmacology & Toxicology

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Chemotherapy for second-stage Human African trypanosomiasis

Lutje

Seixas

Kennedy

2010

Cochrane Database of Systematic Reviews

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Chemotherapy for second-stage Human African trypanosomiasis

Lutje

Seixas

Kennedy

2013

Cochrane Database of Systematic Reviews

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Background Human African trypanosomiasis, or sleeping sickness, is a painful and protracted disease a ecting people in the poorest parts of Africa and is fatal without treatment. Few drugs are currently available for second-stage sleeping sickness, with considerable adverse events and variable e icacy. Objectives To evaluate the e ectiveness and safety of drugs for treating second-stage human African trypanosomiasis.

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Clinical trials of diamidine in Rhodesian sleeping sickness

Cited by 10 publications

References 0 publications

Effect of Repeated Administration of Berenil on Urinary Enzyme Excretion with Corresponding Tissue Pattern in Rats

Effect of Repeated Administration of Berenil on Urinary Enzyme Excretion with Corresponding Tissue Pattern in Rats

Chemotherapy for second-stage Human African trypanosomiasis

Chemotherapy for second-stage Human African trypanosomiasis

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