Clinical trials in older patients with cancer – typical challenges, possible solutions, and a paradigm of study design in breast cancer
Peeter Karihtala,
Aglaia Schiza,
Elena Fountzilas
et al.
Abstract:Background and purpose: While the prevalence of older breast cancer patients is rapidly increasing, these patients are greatly underrepresented in clinical trials. We discuss barriers to recruitment of older patients to clinical trials and propose solutions on how to mitigate these challenges and design optimal clinical trials through the paradigm of IMPORTANT trial.
Patients and methods: This is a narrative review of the current literature evaluating barriers to including older breast cancer patients in clini… Show more
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