Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome – a randomized, double‐blind, controlled study

Simrén, Magnus; Öhman, Lena; Olsson, Jörgen; Svensson, Ulla; Ohlson, Kajsa; Posserud, Iris; Strid, Hans

doi:10.1111/j.1365-2036.2009.04183.x

Cited by 124 publications

(198 citation statements)

References 51 publications

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“…authors' reply SIRS, We wish to thank Dr Ford for his interest 1 in our recent article published in APT. 2 In essence, we agree with the comments made by Dr Ford, and a very likely explanation for the lack of statistical significance between the active treatment group and the control group is that the study was under-powered. However, we have to stress that our assumption of the placebo response rate (15%), using our responder definition, is closer to the observed placebo response in our study (27%), than the pooled placebo response rate from the recent systematic review (43%), 3 mentioned by Dr Ford in his letter.…”

Section: Acknowledgementsupporting

confidence: 39%

Probiotics in irritable bowel syndrome: underachievers or underpowered? authors’ reply

Simrén

Öhman

Olsson³

et al. 2010

Aliment Pharmacol Ther

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Section: Acknowledgementsupporting

confidence: 39%

Probiotics in irritable bowel syndrome: underachievers or underpowered? authors’ reply

Simrén

Öhman

Olsson³

et al. 2010

Aliment Pharmacol Ther

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“…One of those as a full paper later 48 and was included in our sample; another 44 was also published as full paper 30 but was excluded since it was not a probiotic in a strict sense; 2 45,46 had only an English abstract however the full papers were written in Korean and Chinese each. Two frequently included papers reported studies in children.…”

Section: Resultsmentioning

confidence: 99%

“…Six citations were available as abstracts only [42][43][44][45][46][47] and were thus of no value for our study. One of those as a full paper later 48 and was included in our sample; another 44 was also published as full paper 30 but was excluded since it was not a probiotic in a strict sense; 2 45,46 had only an English abstract however the full papers were written in Korean and Chinese each.…”

Section: Resultsmentioning

confidence: 99%

Probiotic Therapy of the Irritable Bowel Syndrome: Why Is the Evidence Still Poor and What Can Be Done About It?

Mazurak

Broelz²,

Storr

et al. 2015

J Neurogastroenterol Motil

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Background/AimsDespite numerous randomized clinical trials and meta-analyses, there is no increased evidence for the efficacy of probiotics in the treatment of irritable bowel syndrome (IBS). We review this evidence, identify and analyse the reasons for this lack of evidence and propose methodological improvements for future studies. MethodsBased on a literature search, we identified 56 papers that matched the purpose of our analyses. Twenty-seven studies used multi-species bacterial preparations and 29 used single-strain probiotics. They were analysed regarding patients included, treatment duration, probiotic dosage, and outcome measures. ResultsTrials in both groups suffered from heterogeneity with respect to probiotic concentration, duration of treatment, and other methodological issues (crossover design and underpowered studies). This heterogeneity did not allow the application of a meta-analytic approach and a systematic review was therefore performed instead. Multi-strain preparations combined 2 to 8 different bacterial subspecies, mostly lactobacilli or bifidobacteria, and used variable lengths of treatments. Overall, more than 50% of trials presented negative outcomes. The majority of the single-strain probiotic trials employing lactobacilli or Saccharomyces were negative, whereas trials employing bifidobacteria showed positive results. ConclusionsThe heterogeneity of the studies of probiotics in IBS questions the value of meta-analyses. The use of different bacterial strains and different mixtures of these strains, as well as different dosages, are the main contributors to this heterogeneity. Current data provides limited evidence for the efficacy of a small number of single-strain probiotics in IBS (mostly bifidobacteria) and

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“…En ambos trabajos concluyeron que se observa una mejoría clínica significativa luego del consumo de probióticos, teniendo en cuenta el dolor abdominal y diarrea al comparar con el consumo de placebo (27)(28)(29)(30)(31)(32). La Tabla 1 resume los hallazgos de los estudios clínicos incluidos en los metaná-lisis previamente mencionados.…”

Section: Síndrome De Intestino Irritableunclassified

Uso de probióticos en síndrome de intestino irritable y enfermedad inflamatoria intestinal: una revisión de la literatura

Gil-Tamayo

et al. 2017

Rev. Colomb. Gastroenterol.

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Introducción: El síndrome de intestino irritable (SII) y la enfermedad inflamatoria intestinal (EII), son motivos de consulta frecuente. Usualmente su tratamiento se hace en primer nivel de atención, con ajuste de estilo de vida y cambios dietarios. Los tratamientos farmacológicos tienen eficacia limitada e importantes efectos secundarios, por lo que existe un interés creciente en terapias diferentes como el uso de probióticos.Métodos: Se realizó una revisión de la literatura en las bases de datos Medline y Embase buscando estudios que asociaran suplementos nutricionales, con SII o EII, haciendo énfasis en probióticos.Resultados: De un total de 1598 referencias, 43 cumplieron criterios finales de inclusión. El uso de probióticos en SII y EII sugiere ser una terapia que ayuda a mantener los periodos de remisión de enfermedad, mejorar la calidad de vida y atenuar el proceso fisiopatológico.Conclusiones: El uso de probióticos y prebióticos podría ser una alternativa de soporte nutricional en pacientes seleccionados.

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Clinical trial: the effects of a fermented milk containing three probiotic bacteria in patients with irritable bowel syndrome – a randomized, double‐blind, controlled study

Abstract: SUMMARY BackgroundThe effects of probiotic bacteria in IBS remain controversial.

Cited by 124 publications

References 51 publications

Probiotics in irritable bowel syndrome: underachievers or underpowered? authors’ reply

Probiotics in irritable bowel syndrome: underachievers or underpowered? authors’ reply

Probiotic Therapy of the Irritable Bowel Syndrome: Why Is the Evidence Still Poor and What Can Be Done About It?

Uso de probióticos en síndrome de intestino irritable y enfermedad inflamatoria intestinal: una revisión de la literatura

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