Clinical Trial Registration in Oral Health Journals

Smaïl-Faugeron, Violaine; Hélène, F; Durieux, Pierre

doi:10.1177/0022034514552492

Cited by 36 publications

(53 citation statements)

References 16 publications

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“…Prospective registration of clinical trials is necessary to promote study fidelity and data sharing. Unfortunately, some studies of dental clinical trials have found that only around 24–25 percent of clinical trials in the fields of dentistry and orthodontics are prospectively registered . Because of this, the volume of normative data sets available for public oral health research is lacking in some regards.…”

Section: Discussionmentioning

confidence: 99%

Using big data to promote precision oral health in the context of a learning healthcare system

Finkelstein

Zhang

Levitin

et al. 2020

J Public Health Dent

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Summary There has been a call for evidence‐based oral healthcare guidelines, to improve precision dentistry and oral healthcare delivery. The main challenges to this goal are the current lack of up‐to‐date evidence, the limited integrative analytical data sets, and the slow translations to routine care delivery. Overcoming these issues requires knowledge discovery pipelines based on big data and health analytics, intelligent integrative informatics approaches, and learning health systems. This article examines how this can be accomplished by utilizing big data. These data can be gathered from four major streams: patients, clinical data, biological data, and normative data sets. All these must then be uniformly combined for analysis and modelling and the meaningful findings can be implemented clinically. By executing data capture cycles and integrating the subsequent findings, practitioners are able to improve public oral health and care delivery.

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Section: Discussionmentioning

confidence: 99%

Using big data to promote precision oral health in the context of a learning healthcare system

Finkelstein

Zhang

Levitin

et al. 2020

J Public Health Dent

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“…However, it has recently been shown that only one‐quarter of RCTs published in oral health journals are publicly registered (Smail‐Faugeron et al. ).…”

Section: Discussionmentioning

confidence: 99%

Clinical research activity in periodontal medicine: a systematic mapping of trial registers

Monsarrat

Blaizot

Kémoun

et al. 2016

J Clinic Periodontology

139

101

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“…The dental research community falls far behind our medical colleagues in this respect and it has important implications for transparency of trials. 22 All Trials is campaigning for this and provides an excellent resource explaining the importance of trial registration and result reporting. 23 Once the trial has been carried out (no mean feat in itself but not the focus of this paper), there is often a failure to report details in the manuscripts published in journals.…”

Section: Clinical Trials: What Can Be Done At the Primary Research Stmentioning

confidence: 99%

How do we create, and improve, the evidence base?

2016

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Providing best clinical care involves using the best available evidence of effectiveness to inform treatment decisions. Producing this evidence begins with trials and continues through synthesis of their findings towards evidence incorporation within comprehensible, usable guidelines, for clinicians and patients at the point of care. However, there is enormous wastage in this evidence production process, with less than 50% of the published biomedical literature considered sufficient in conduct and reporting to be fit for purpose. Over the last 30 years, independent collaborative initiatives have evolved to optimise the evidence to improve patient care. These collaborations each recommend how to improve research quality in a small way at many different stages of the evidence production and distillation process. When we consider these minimal improvements at each stage from an 'aggregation of marginal gains' perspective, the accumulation of small enhancements aggregates, thereby greatly improving the final product of 'best available evidence'. The myriad of tools to reduce research quality leakage and evidence loss should be routinely used by all those with responsibility for ensuring that research benefits patients, that is, those who pay for research (funders), produce it (researchers), take part in it (patients/participants) and use it (clinicians, policy makers and service commissioners).

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Clinical Trial Registration in Oral Health Journals

Cited by 36 publications

References 16 publications

Using big data to promote precision oral health in the context of a learning healthcare system

Using big data to promote precision oral health in the context of a learning healthcare system

Clinical research activity in periodontal medicine: a systematic mapping of trial registers

How do we create, and improve, the evidence base?

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