Clinical trial of vitamin A supplementation in infants susceptible to bronchopulmonary dysplasia

Shenai, Jayant P.; Kennedy, Kathleen A.; Chytil, Frank; Stahlman, Mildred T.

doi:10.1016/s0022-3476(87)80086-0

Cited by 321 publications

(146 citation statements)

References 18 publications

Supporting

Mentioning

134

Contrasting

Unclassified

Order By: Relevance

“…BPD is primarily a delay in alveolar development (Husain et al, 1998) with reduced numbers of alveoli and reduced microvasculature development (Bhatt et al, 2001;Lassus et al, 2001). The development of BPD is associated with low concentrations of vitamin A in preterm babies (Shenai et al, 1985(Shenai et al, , 1987(Shenai et al, , 1990Bland et al, 2003), and postnatal treatment with vitamin A (retinol) administered intramuscularly reduced the incidence of BPD by 7% in a multicenter trial (Tyson et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

All‐Trans Retinoic Acid and Intra‐Amniotic Endotoxin‐Mediated Effects on Fetal Sheep Lung

Kramer¹,

Albertine²,

Moss³

et al. 2008

The Anatomical Record

View full text Add to dashboard Cite

All-trans retinoic acid (RA) is a potent modulator of lung development. Chorioamnionitis, which is frequently associated with preterm birth, causes fetal lung inflammation and improves lung function but also results in alveolar simplification and microvascular injury. Endotoxin-mediated chorioamnionitis reduces RA concentration in the fetal lung to 16% of control values. We hypothesized that administration of RA to the fetus before induction of chorioamnionitis would preserve septation of the distal airspaces. Time-mated ewes with singletons were assigned to receive a fetal intramuscular treatment with 20,000 IU of RA in olive oil (or olive oil only) 3 hr prior to intra-amniotic injection of endotoxin (20 mg, E. coli 055:B5) or saline, at 124-day gestational age and 7 days after the fetal treatment. The right cranial lung lobe was processed for morphometric analysis. RA treatment did not affect chorioamnionitis-induced fetal and systemic inflammation or interleukin-8 concentrations in lung tissue. RA administration alone did not alter lung structure. Relative to control lungs (5 6 3 mL/kg), lung volume increased similarly with endotoxin (22 6 4 mL/kg) or RA plus endotoxin (20 6 3 mL/kg; P < 0.05). Alveolar wall thickness was 4.2 6 0.3 mm after endotoxin-induced chorioamnionitis, 6.0 6 0.4 mm in controls (P < 0.05 versus endotoxin) and 5.5 6 0.2 mm after RA and endotoxin (P < 0.05 versus control, n.s. versus endotoxin). The ratio of airspace versus tissue was 4.6 6 0.3 in endotoxin-induced chorioamnionitis, 2.1 6 0.3 in controls and 4.1 6 0.5 after RA and endotoxin. We conclude that fetal treatment with RA did not prevent inflammation-induced alveolar simplification.

show abstract

Section: Introductionmentioning

confidence: 99%

All‐Trans Retinoic Acid and Intra‐Amniotic Endotoxin‐Mediated Effects on Fetal Sheep Lung

Kramer¹,

Albertine²,

Moss³

et al. 2008

The Anatomical Record

View full text Add to dashboard Cite

show abstract

“…2 Multiple randomized controlled trials and a systematic review have shown that vitamin A supplementation decreases BPD or death. [3][4][5] In a recent multicenter trial conducted by the NICHD Neonatal Research Network, vitamin A supplementation of 5000 IU/dose given intramuscularly (i.m.) three times/week for 4 weeks decreased death rate or BPD at 36 weeks' postmenstrual age (55 vs 62%; relative risk 0.89; 95% confidence interval (CI) 0.80 to 0.99), due to a decrease in the rate of BPD.…”

Section: Introductionmentioning

confidence: 99%

Retinol-Binding Protein, Transthyretin, and C-Reactive Protein in Extremely Low Birth Weight (ELBW) Infants

2005

View full text Add to dashboard Cite

BACKGROUND:Vitamin A deficiency reduces retinol binding protein (RBP) but not transthyretin (TTR), while inflammation reduces both RBP and TTR and increases C-reactive protein (CRP), an acute phase reactant. OBJECTIVE:To estimate serum RBP, TTR, and CRP in ELBW infants to test the hypotheses that (a) TTR is a negative acute phase reactant and (b) a higher RBP/TTR ratio or CRP is associated with death/BPD by 36 weeks corrected age. DESIGN/METHODS:Serum RBP, TTR, and CRP were measured in 79 ELBW infants at 28 days. Area under the curve (AUC) of receiver operating characteristic curve analysis evaluated the predictive value of TTR, the RBP/TTR ratio, and CRP for death/BPD at 36 weeks. RESULTS:(1) TTR inversely correlated with CRP (r ¼ À0.45, p<0.0001) consistent with TTR being a negative acute phase reactant. (2) The RBP/TTR ratio predicted death/BPD (AUC 0.68 (CI 0.57 to 0.78)). (3) CRP strongly predicted death/BPD (AUC 0.85 (CI 0.76 to 0.92)), even after exclusion of sepsis. CONCLUSIONS:A higher CRP and RBP/TTR molar ratio on day 28 are associated with death/BPD at 36 weeks in ELBW infants. Lower TTR and maintained RBP/TTR ratios suggest inflammation rather than vitamin A deficiency as the cause for lower serum vitamin A levels in ELBW infants.

show abstract

“…Thus, the vitamin A supply is improved via the regular hepatic export pathway. Such an increase of the vitamin A concentration in the systemic circulation diminishes obviously the morbidity and mortality of prematures due to bronchopulmonal dysplasia (Shenai et al, 1987(Shenai et al, , 1990. Dexamethason, respectively glucocorticoids, not only lead to an improvement of the total vitamin A supply through a change of the release from the liver, but they also influence, as recently described (Geevarghese & Chytil, 1994), the metabolization of the vitamin A esters, which are stored in the lung.…”

Section: Protecting Factorsmentioning

confidence: 88%

Meat and cancer: meat as a component of a healthy diet

Biesalski

2002

Eur J Clin Nutr

View full text Add to dashboard Cite

Based on epidemiological studies it is assumed that meat, especially red meat, enhances risk for cancer, particulary of the colon, breast and prostate. Meat and meat products are important sources of protein, some micronutrients and fat. High fat intake has been blamed for correlation with different diseases, including cancer. Meat protein is reported to contribute to cancer formation. However, meat, including liver, is not only composed of fat and protein, it contains essential nutrients which appear exclusively in meat (vitamin A, vitamin B 12 ) and micronutrients for which meat is the major source because of either high concentrations or better bioavailability (folate, selenium, zinc). In particular, vitamin A, folate and selenium are reported to be cancer-preventive, with respect to colon, breast and prostate cancer. Taken together, meat consists of a few, not clearly defined cancer-promoting and a lot of cancer-protecting factors. The latter can be optimized by a diet containing fruit and vegetables, which contain hundreds of more or less proven bioactive constituents, many of them showing antioxidative and anticarcinogenic effects in vitro.

show abstract

Clinical trial of vitamin A supplementation in infants susceptible to bronchopulmonary dysplasia

Cited by 321 publications

References 18 publications

All‐Trans Retinoic Acid and Intra‐Amniotic Endotoxin‐Mediated Effects on Fetal Sheep Lung

All‐Trans Retinoic Acid and Intra‐Amniotic Endotoxin‐Mediated Effects on Fetal Sheep Lung

Retinol-Binding Protein, Transthyretin, and C-Reactive Protein in Extremely Low Birth Weight (ELBW) Infants

Meat and cancer: meat as a component of a healthy diet

Contact Info

Product

Resources

About