Clinical trial of oral diosmin (Daflon®) in the treatment of hemorrhoids

Abstract

A double-blind, comparative, controlled study on the effectiveness of the addition of oral diosmin (Daflon; Lab. Servier, Orléans, France) and placebo to a conservative regimen of bulk laxative in the treatment of acute symptoms of first-degree and second-degree internal hemorrhoids was undertaken in 100 patients. The diosmin and placebo groups, with 50 patients each, were comparable in age, sex, symptoms, and the severity of the underlying hemorrhoids. During the first four days, the patients received 12 tablets in three divided doses, and then they received two tablets twice daily for another 10 days. Subjective and objective changes were assessed at the 4th and 14th days of treatment. The diosmin group showed statistically significant objective improvement (P < 0.01) without accompanying subjective improvement on the fourth day. However, at day 14, there was no significant difference in either subjective or objective improvement between the two groups. Two cases in the placebo group were taken out of the trial on the fourth day owing to clinical deterioration. No side effect of diosmin was detected in this study.

Meta-analysis of flavonoids for the treatment of haemorrhoids

“…). All but one study37 showed either a trend or a significant difference in favour of the flavonoid group. The pooled analysis showed a 67 per cent reduction in the RR of bleeding or remaining symptomatic in the active treatment arm (RR 0·33 (95 per cent c.i.…”

“…Fourteen studies (1514 patients), all parallel‐group randomized trials comparing a flavonoid versus placebo, met the eligibility criteria. Eight investigations studied diosmin31 or a standard mixture of micronized diosmin plus hesperidin32–37, also known as micronized purified flavonoid fraction (MPFF). The other seven trials studied rutosides38–44 ( Table 1 ).…”

Rectogesic® (glyceryl trinitrate 0.2%) ointment relieves symptoms of haemorrhoids associated with high resting anal canal pressures

“…This was shown to reduce rectal bleeding in randomized controlled trials [25][26][27][28][29], but as the follow-up period was short, the longterm effects were unknown. Certainly dietary management has less side effects compared with RectogesicÒ or any of the ambulatory techniques which are commonly used.…”

Hemorojaus gydymas sudėtiniu preparatu Ginkor Fort

“…Vazoaktyviøjø medþiagø, nurodytø 3 lentelëje, poveikis iðtirtas blogiau, taèiau ðios medþiagos vis tiek labai populiarios. Atlikti keturi diosmino poveikio tyrimai [9][10][11][12]. Pirmieji du nurodë nedidelá skausmo ir iðskyrø sumaþëjimà.…”

“…Pirmieji du nurodë nedidelá skausmo ir iðskyrø sumaþëjimà. Treèiasis tyrimas [11] nepatvirtino papildomo diosmino poveikio hemorojaus simptomams vartojant skaidulas. Ðiuo tyrimu nustatyta, kad bûklë pagerëjo 94 % ligoniø, vartojanèiø skaidulas, ir 98 % ligoniø, vartojanèiø skaidulas ir diosminà.…”