Clinical trial of nicardipine cardioplegia in pediatric cardiac surgery

Mori, Fumiki; Miyamoto, Masaki; Tsuboi, Hidetoshi; Noda, Hiroshi; Esato, Kensuke

doi:10.1016/0003-4975(90)90246-3

Cited by 14 publications

(3 citation statements)

References 22 publications

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“…Optimal concentration in warm blood is undetermined [91]. In human neonates, the addition of nicardipine, a calcium-channel blocker, to crystalloid cardioplegia may reduce myocardial injury [147], although nifedipine was not effective in adults [148] Magnesium supplementation. 5-10 mmol/l added to cold blood cardioplegia may be associated with less ATP depletion [149], less troponin release and possibly improved performance in humans [150].…”

Section: Increased Basal Vascular Tone and Propensity To Spasmmentioning

confidence: 99%

Vasomotor dysfunction after cardiac surgery

Ruel

Khan

Voisine

et al. 2004

European Journal of Cardio-Thoracic Surgery

106

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Cardiopulmonary bypass and cardioplegic arrest, which allow for support of the circulation and stabilization of the heart during cardiac procedures, are still used for the vast majority of cardiac operations worldwide. However, in addition to a well-recognized systemic inflammatory response, cardiopulmonary bypass and cardioplegic arrest elicit complex, multifactorial vasomotor disturbances that vary according to the affected organ bed, with reduced vascular resistances in the skeletal muscle and peripheral circulation, and increased propensity to spasm in the cardiac, pulmonary, mesenteric and cerebral vascular beds. This article outlines the nature, mechanistic basis, and clinical correlates of the vasomotor alterations encountered in patients undergoing cardiac surgery using cardiopulmonary bypass and cardioplegic arrest.

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Section: Increased Basal Vascular Tone and Propensity To Spasmmentioning

confidence: 99%

Vasomotor dysfunction after cardiac surgery

Ruel

Khan

Voisine

et al. 2004

European Journal of Cardio-Thoracic Surgery

106

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show abstract

“…In addition to vascular smooth muscle selectivity, prior study in children has observed that cardioplegic solutions incorporating nicardipine improved postoperative cardiac performance and lessened the release of myocardial enzymes [21]. Although further study is warranted to define the myocardial protective mechanisms of nicardipine, these fundamental studies support the application of nicardipine for intraoperative and postoperative treatment of hypertension in children, particularly in the setting of reduced biventricular function.…”

Section: Commentmentioning

confidence: 88%

Use of Nicardipine After Cardiac Operations Is Safe in Children Regardless of Age

Stone

Kelly

Mistry

et al. 2018

The Annals of Thoracic Surgery

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“…Nicardipine has less negative inotropic effects and produces less tachycardia then the other calcium channel antagonists [13]. It reduces cardiac oxygen consuption [5] and has a myocardial protective effect [11]. These properties are especially important for management of hypertensive episodes in patients.…”

Section: References Discussionmentioning

confidence: 99%

Intravenous nicardipine in hypertensive children

et al. 1993

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Fourteen hypertensive patients hospitalized in a paediatric intensive care unit were studied to evaluate safety and hypotensive efficacy of intravenous nicardipine. Systolic and diastolic blood pressure significantly decreased 1 h after the beginning of the treatment (1 microgram/kg per minute). Mean decrease in systolic blood pressure during the first 24 h was between 9.9% and 13.4% of the initial value. Mean lowering of diastolic blood pressure was between 16.7% and 25.6%. Nicardipine did not significantly affect heart rate with dose of 1 microgram/kg per minute. No clinical side-effects were observed. Nicardipine could be a first line drug for the treatment of hypertension in paediatric intensive care units.

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Clinical trial of nicardipine cardioplegia in pediatric cardiac surgery

Cited by 14 publications

References 22 publications

Vasomotor dysfunction after cardiac surgery

Vasomotor dysfunction after cardiac surgery

Use of Nicardipine After Cardiac Operations Is Safe in Children Regardless of Age

Intravenous nicardipine in hypertensive children

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