Clinical trial of moxidectin oral gel in horses

DiPietro, Janet A.; Hutchens, Douglas E.; Lock, T.F.; Walker, Kathy; Paul, Allan; Shipley, Clifford F.; Rulli, Dino

doi:10.1016/s0304-4017(97)01108-4

Cited by 40 publications

(14 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The faecal egg count reductions indicated activity of all 3 anthelmintics against the strongyle parasites, although efficacy varied. While moxidectin had the highest efficacy in this study, there were some indications of strongyle egg reappearance by Day 42 (data not shown), which is considerably sooner than the 12-16 weeks initially reported for this drug [10,11]. This early reappearance of eggs has been found in other recent studies, and is being interpreted as emerging moxidectin resistance [12].…”

Section: Discussionsupporting

confidence: 65%

Characterisation of the inflammatory cytokine response to anthelmintic treatment in ponies

Betancourt

Lyons

Horohov

2014

Equine Veterinary Journal

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 65%

Characterisation of the inflammatory cytokine response to anthelmintic treatment in ponies

Betancourt

Lyons

Horohov

2014

Equine Veterinary Journal

View full text Add to dashboard Cite

show abstract

“…The delay in the eggs reappearance time as was observed with IVM injected IM could provide a therapeutic advantage in comparison with the oral route in the control of parasites in horses. Decreased anthelmintic use is likely to be more cost effective and less likely to promote the development of anthelmintic‐resistant parasite populations (Di Pietro et al., 1997). Among the factors contributing to resistance, frequent dosing is the most important and depending on the genetic basis of resistance, under‐dosing may be an important contributory factor.…”

Section: Discussionmentioning

confidence: 99%

Plasma Profiles of Ivermectin in Horses following Oral or Intramuscular Administration

Pérez

Godoy

Palma

et al. 2003

Journal of Veterinary Medicine Series A

View full text Add to dashboard Cite

A study was undertaken in order to evaluate and compare ivermectin's (IVM) plasma disposition kinetic parameters after oral or intramuscular (IM) administration in horses. Ten clinically healthy adult horses, weighing 380-496 kg body weight (BW), were allocated to two experimental groups of five horses. Group I, was treated with an oral paste formulation of IVM at the manufacturer's recommended dose of 0.2 mg/kg BW. Group II, was treated IM with an injectable 1% formulation of IVM at a dose of 0.2 mg/kg BW. Blood samples were collected by jugular puncture at different times between 0.5 h and 75 days post-treatment. After plasma extraction and derivatization, samples were analysed by high-performance liquid chromatography with fluorescence detection. A computerized kinetic analysis was performed, and data were compared using the Wilcoxon signed rank test. The parent molecule was detected in plasma between 30 min and either 20 (oral) or 40 (IM) days post-treatment. Significant differences were found for the time corresponding to peak plasma concentrations (tmax) and for absorption half-life. Peak plasma concentrations (Cmax) of 51.3 +/- 16.1 ng/ml (mean +/- SD) were obtained after oral administration and of 31.4 +/- 6.0 ng/ml for the IM route. The values for area under concentration-time curve were 137.1 +/- 35.9 ng day/ml for the group treated orally, and 303.2 +/- 4.3 ng day/ml for the IM treated group. The mean plasma residence times were 4.2 +/- 0.4 and 8.9 +/- 0.7 days for oral and IM-treated groups, respectively. The results of this study show that the route of administration considerably affects the disposition of IVM. A significant difference in bioavailabilty and half-life of elimination of IVM was observed after IM administration compared with oral administration. A close relationship between pharmacokinetic profiles and the clinical efficacy of IVM was established.

show abstract

“…In Population C, the cyathostomins were deemed IVM sensitive as indicated by the finding of a mean FECR of >95% in treated animals 14 days after IVM administration (Table 1); however, the strongyle egg reappearance period for some of the donkeys in this population was below the standard egg suppression period of IVM and MOX (F. Burden, pers comm. ), described previously in horses as 8 weeks (Lyons et al, 1992;Bello, 1996) and 13 weeks (DiPietro et al, 1997), respectively. It should be noted that there are no published studies on the ERP of strongyle infections after IVM treatment in donkeys in drug-sensitive populations.…”

Section: Populationsmentioning

confidence: 93%

Development of the larval migration inhibition test for comparative analysis of ivermectin sensitivity in cyathostomin populations

McArthur

Handel

Robinson

et al. 2015

Veterinary Parasitology

View full text Add to dashboard Cite

Cyathostomins are the most prevalent parasitic pathogens of equids worldwide. These nematodes have been controlled using broad-spectrum anthelmintics; however, cyathostomin resistance to each anthelmintic class has been reported and populations insensitive to more than one class are relatively commonplace. The faecal egg count reduction test (FECRT) is considered the most suitable method for screening anthelmintic sensitivity in horses, but is subject to variation and is relatively time-consuming to perform. Here, we describe a larval migration inhibition test (LMIT) to assess ivermectin (IVM) sensitivity in cyathostomin populations. This test measures the paralysing effect of IVM on the ability of third stage larvae (L3) to migrate through a pore mesh. When L3 from a single faecal sample were examined on multiple occasions, variation in migration was observed: this was associated with the length of time that the L3 had been stored before testing but the association was not significant. Half maximal effective concentration (EC50) values were then obtained for cyathostomin L3 from six populations of horses or donkeys that showed varying sensitivity to IVM in previous FECRTs. Larvae from populations indicated as IVM resistant by FECRT displayed significantly higher EC50 values in the LMIT than L3 from populations classified as IVM sensitive or L3 from populations that had not been previously exposed to IVM or had limited prior exposure. The analysis also showed that EC50 values obtained using L3 from animals in which IVM faecal egg count reduction (FECR) levels had been recorded as <95% were significantly higher than EC50 values obtained using L3 from animals for which FECR was measured as >95%. For one of the populations, time that had elapsed since IVM administration had an effect on the EC50 value obtained, with a longer time since treatment associated with lower EC50 values. These results indicate that the LMIT has value in discriminating IVM sensitivity amongst cyathostomin populations, but several factors were identified that need to be taken into account when executing the test and interpreting the derived data.

show abstract

Clinical trial of moxidectin oral gel in horses

Cited by 40 publications

References 10 publications

Characterisation of the inflammatory cytokine response to anthelmintic treatment in ponies

Characterisation of the inflammatory cytokine response to anthelmintic treatment in ponies

Plasma Profiles of Ivermectin in Horses following Oral or Intramuscular Administration

Development of the larval migration inhibition test for comparative analysis of ivermectin sensitivity in cyathostomin populations

Contact Info

Product

Resources

About