“…White and McCawley (1950) have reported that diphenhydramine is effective in preventing ventricular extrasystoles and tachycardia produced by cyclopropane and adrenaline in dogs. Burn (1950) and DiPalma and Schults (1950) suggested the clinical use of antihistamines as quinidine substitutes, and Dick and McCawley (1951) have demonstrated that they are effective against auricular fibrillation in man.…”