Clinical Trial of Desferrioxamine Entrapped in Red Cell Ghosts

Green, Ralph; Lamon, Joel M.; Curran, Deborah

doi:10.1016/s0140-6736(80)90336-0

Cited by 37 publications

(7 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is possible that accumulation of high concentrations of drug within the cochlea owing to the very slow rate of removal of perilymph could be responsible for the damage observed in this patient, and thus be similar to that brought about by diuretics and 8-aminoglycosides (Hybels, 1979). In this respect, the recent use of DF-containing red cell ghosts, which may allow delivery of drug to specific sites of iron storage, may render this kind of side effect avoidable in the future (Green, Lamon and Curran, 1980). However, in view of the uncertainty concerning mechanisms of inner ear toxicity, a rational explanation for the occurrence of tinnitus in this one patient is difficult to conceive.…”

Section: Discussionmentioning

confidence: 85%

Tinnitus in a patient with beta-thalassaemia intermedia on long-term treatment with desferrioxamine

Marsh

Holbrook

Clark

et al. 1981

Postgraduate Medical Journal

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 85%

Tinnitus in a patient with beta-thalassaemia intermedia on long-term treatment with desferrioxamine

Marsh

Holbrook

Clark

et al. 1981

Postgraduate Medical Journal

View full text Add to dashboard Cite

show abstract

“…The former is based on the fact that exposing erythrocytes in a hypotonic solution will lead to an enhancement in the permeability of the membrane and an enlargement of pores in the membrane. And this type includes hypotonic hemolysis, hypotonic dilution, hypotonic dialysis, hypotonic preswelling, osmotic pulse, and so forth [25][26][27][28][29]. The latter includes electroporation, chemical perturbation, protein recombinant, and drug-induced membrane internalization, etc.…”

Section: Drug Deliverymentioning

confidence: 99%

Thermo-fluidic devices and materials inspired from mass and energy transport phenomena in biological system

Xiao

Liu

2008

Front. Energy Power Eng. China

View full text Add to dashboard Cite

Mass and energy transport consists of one of the most significant physiological processes in nature, which guarantees many amazing biological phenomena and activities. Borrowing such idea, many state-of-the-art thermofluidic devices and materials such as artificial kidneys, carrier erythrocyte, blood substitutes and so on have been successfully invented. Besides, new emerging technologies are still being developed. This paper is dedicated to presenting a relatively complete review of the typical devices and materials in clinical use inspired by biological mass and energy transport mechanisms. Particularly, these artificial thermo-fluidic devices and materials will be categorized into organ transplantation, drug delivery, nutrient transport, micro operation, and power supply. Potential approaches for innovating conventional technologies were discussed, corresponding biological phenomena and physical mechanisms were interpreted, future promising mass-and-energytransport-based bionic devices were suggested, and prospects along this direction were pointed out. It is expected that many artificial devices based on biological mass and energy transport principle will appear to better improve various fields related to human life in the near future.

show abstract

“…These loaded cells have been utilized as microcontainers for selective delivery of their contents to the reticuloendothelial cells or to disseminate them in the circulatory system achieving sustained release, or to function as circulating bioreactors (Zocchi et al 1988, Ihler 1983, Green et al 1981, De Flora et al 1986). Glutaraldehyde treatment of erythorocytes has been reported to target them to liver and spleen (DeLoach et al 1977, Zocchi et al 1988).…”

Section: Introductionmentioning

confidence: 99%

Erythrocyte based delivery system of primaquine:in vitrocharacterization

Talwar

Jain

1992

Journal of Microencapsulation

View full text Add to dashboard Cite

Primaquine phosphate, an antimalarial drug, was loaded in erythrocytes by the process of endocytosis. The encapsulation of 0.1-0.15 mg of drug ml-1 of packed erythrocytes was achieved. The loaded cells attained spherical shape and exhibited higher osmotic fragility and lower resistance to turbulence shock as compared with normal cells. Glutaraldehyde treatment stabilized the cells which were noted to be resistant to the osmotic and turbulence shocks. In vitro release of drug and haemoglobin was also retarded upon treatment of loaded erythrocytes with glutaraldehyde. The studies suggest the potentiality of primaquine-loaded, glutaraldehyde-treated erythrocytes as an intravenous drug delivery system for casual prophylaxis and radical cure of malaria.

show abstract

Clinical Trial of Desferrioxamine Entrapped in Red Cell Ghosts

Cited by 37 publications

References 8 publications

Tinnitus in a patient with beta-thalassaemia intermedia on long-term treatment with desferrioxamine

Tinnitus in a patient with beta-thalassaemia intermedia on long-term treatment with desferrioxamine

Thermo-fluidic devices and materials inspired from mass and energy transport phenomena in biological system

Erythrocyte based delivery system of primaquine:in vitrocharacterization

Contact Info

Product

Resources

About