Clinical trial of deglycyrrhizinised liquorice in gastric ulcer.

Bardhan, Karna Dev; Cumberland, D.C.; Dixon, R A; Holdsworth, C D

doi:10.1136/gut.19.9.779

Cited by 22 publications

(8 citation statements)

References 4 publications

(3 reference statements)

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“…In a trial for gastric ulcer disease (Bardhan et al, 1978), however, liquorice did not demonstrate any benefit. The effects first reported by Dioscorides and Al Razi referring to beneficial effects on excessive tissue growth around nails, in the eye and in form of tumours have been confirmed in vitro by demonstrating that liquorice causes apoptosis.…”

Section: Results Of Bioscientific Research Referring To the Historicamentioning

confidence: 88%

A history of the therapeutic use of liquorice in Europe

Fiore

Eisenhut

Ragazzi

et al. 2005

Journal of Ethnopharmacology

336

206

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Liquorice root has been used in Europe since prehistoric times, and is well documented in written form starting with the ancient Greeks. In this review we compare the independent development of medical uses of this botanical drug in several ancient cultures, attempting to show the rationality of specific indications across different ethnic groups with different cultural backgrounds. Identical specific indications in different cultures highlight universally reproducible therapeutic effects that are beyond those of a mere placebo. In the first part of the review, historical sources dealing with liquorice (Scythian, Greek, Roman, and from the Middle Ages in Germany, Italy, Spain, England) have been considered. In the second part, the historical records of diseases treated with liquorice have been presented. Finally, a comparison between traditional use in and outside Europe, with the most important recent scientific studies concerning its use, is presented.

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Section: Results Of Bioscientific Research Referring To the Historicamentioning

confidence: 88%

A history of the therapeutic use of liquorice in Europe

Fiore

Eisenhut

Ragazzi

et al. 2005

Journal of Ethnopharmacology

336

206

View full text Add to dashboard Cite

show abstract

“…The use of G. glabra extract as antiulcerative is widely known. For the gastrointestinal system, it is used in gastric and duodenal ulcers (Bardhan, Cumberland, Dixon, & Holdsworth, ), whereas for the treatment of spasmodic pains of chronic gastritis, it is employed as an adjuvant (Armanini et al, ). The benefits of G. glabra in the treatment of duodenal and peptic ulcers have been reported since the 1970s, and this traditional use is related to the presence of anti‐inflammatory saponins (Krausse et al, ).…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

“…Nevertheless, the glycyrrhetic acid derivative carbenoxolone presents secondary effects such as the potential development of pseudo aldosteronism, which limits its use. In a clinical trial, Bardhan et al () studied the effect of liquorice by oral administration in 96 patients with gastric ulcer. The patients were randomly allocated to the treatment either with deglycyrrhizinated liquorice or with placebo.…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

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Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review

Pastorino

Cornara

Soares

et al. 2018

Phytotherapy Research

513

332

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In the last years, consumers are paying much more attention to natural medicines and principles, mainly due to the general sense that natural compounds are safe. On the other hand, there is a growing demand by industry for plants used in traditional medicine that could be incorporated in foods, nutraceuticals, cosmetics, or even pharmaceuticals. Glycyrrhiza glabra Linn. belongs to the Fabaceae family and has been recognized since ancient times for its ethnopharmacological values. This plant contains different phytocompounds, such as glycyrrhizin, 18β-glycyrrhetinic acid, glabrin A and B, and isoflavones, that have demonstrated various pharmacological activities. Pharmacological experiments have demonstrated that different extracts and pure compounds from this species exhibit a broad range of biological properties, including antibacterial, anti-inflammatory, antiviral, antioxidant, and antidiabetic activities. A few toxicological studies have reported some concerns. This review addresses all those issues and focuses on the pharmacological activities reported for G. glabra. Therefore, an updated, critical, and extensive overview on the current knowledge of G. glabra composition and biological activities is provided here in order to explore its therapeutic potential and future challenges to be utilized for the formulation of new products that will contribute to human well-being.

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“…Clinical Studies: In a double-blind RCT, 30-days treatment with GutGuard ® significantly decreased symptoms of Indian patients with functional dyspepsia [91], and was also significantly effective in patients with H. pylori infection [89]. Bardhan and colleagues reported no significant effect of deglycyrrhizinised liquorice on gastric ulcer in an RCT of British patients [15]; whereas, Brogden and associates had earlier reported it effective in peptic ulcers [20]. Treatment of healthy men with licorice for one-week decreased salivary testosterone values by 26% but no significant decrease in free testosterone [7], and nine healthy women treated with 3.5 g of licorice containing 7.6% of GR daily for two cycles, had their mean total serum testosterone decreased by 37% at the end of 2nd month.…”

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confidence: 99%

Glycyrrhiza glabra L. (Fabaceae/Leguminosae)

Akbar

2020

Handbook of 200 Medicinal Plants

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Liquorice is a perennial, temperate-zone herb or subshrub, native of India, Pakistan and southern Europe; also cultivated in England, and Iraq. It has also been grown experimentally in the United States. Ancient historical manuscripts from China, India and Greece mention its use for symptoms of viral respiratory tract infections and hepatitis. The plant has also been described by Theophrastus. Licorice from Egypt has been described to be the best, followed by from Iraq and Syria; the root should be decorticated before use. It concocts viscid humours in diseases of liver, bladder and lungs, and expectorates them. It has been used in Iranian herbal medicine for skin eruptions, including dermatitis, eczema, pruritus and cysts, and for treatment of stomach disorders including peptic ulcers. The herb extract inhibits gastric motility in vivo, which is regarded to be an important aspect for its antiulcer activity. Licorice possesses both anti-inflammatory and antiulcer activities; whereas most antiinflammatory agents are ulcerogenic. Former German Commission E believed it to be effective in the treatment of atopic dermatitis. Licorice root has been used for years to regulate gastrointestinal function in TCM, has been used for generations as an antidote, demulcent, and elixir in folk medicine of China, and is the most commonly used crude drug in Kampo Medicines, the Japanese form of modified TCM, for the treatment of peptic ulcer. Roots contain glycyrrhizin, the main water-soluble constituent that is 50Â sweeter than sugar, 2-b-glucuronosyl glucuronic acid, and isoliquiritigenin-4-glucoside. Glycyrrhizin is a nonhemolytic saponin with foaming property, and one of the most potent hydroxyl radical scavengers. No significant effect of deglycyrrhizinised liquorice was observed on gastric ulcer in an RCT of British patients. Treatment of healthy men with licorice for one-week decreased salivary testosterone values by 26% but no significant decrease in free testosterone, and nine healthy women treated with licorice daily © Springer Nature Switzerland AG 2020 S. Akbar, Handbook of 200 Medicinal Plants, https://doi.org/10.1007/978-3-030-16807-0_103 963 for two cycles, had their mean total serum testosterone decreased by 37% at the end of 2nd month. This property could be useful as an adjunct therapy of hirsutism and PCOS.Description: Liquorice is a perennial, temperate-zone herb or subshrub, native of India, Pakistan and southern Europe; also cultivated in England,

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Clinical trial of deglycyrrhizinised liquorice in gastric ulcer.

Cited by 22 publications

References 4 publications

A history of the therapeutic use of liquorice in Europe

A history of the therapeutic use of liquorice in Europe

Liquorice (Glycyrrhiza glabra): A phytochemical and pharmacological review

Glycyrrhiza glabra L. (Fabaceae/Leguminosae)

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