Clinical treatment of intra-epithelia cervical neoplasia with photodynamic therapy

Vendette, Antonio Carlos Figueiredo; Piva, Henrique Luís; Muehlmann, Luís Alexandre; Souza, Delfrank Ananias de; Tedesco, Antônio Cláudio; Azevedo, Ricardo Bentes

doi:10.1080/02656736.2020.1804077

Cited by 13 publications

(9 citation statements)

References 23 publications

(25 reference statements)

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“…In terms of incidence and mortality rate, the fourth most common malignancy among women globally is cervical cancer [121]. Classical treatment strategies against this disease cause side effects, including pain and bleeding, and can even compromise the patients' reproductive capacity, effects that no longer appear when using PDT [9,122].…”

Section: Malignant Diseasesmentioning

confidence: 99%

Photodynamic Therapy—An Up-to-Date Review

2021

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The healing power of light has attracted interest for thousands of years. Scientific discoveries and technological advancements in the field have eventually led to the emergence of photodynamic therapy, which soon became a promising approach in treating a broad range of diseases. Based on the interaction between light, molecular oxygen, and various photosensitizers, photodynamic therapy represents a non-invasive, non-toxic, repeatable procedure for tumor treatment, wound healing, and pathogens inactivation. However, classic photosensitizing compounds impose limitations on their clinical applications. Aiming to overcome these drawbacks, nanotechnology came as a solution for improving targeting efficiency, release control, and solubility of traditional photosensitizers. This paper proposes a comprehensive path, starting with the photodynamic therapy mechanism, evolution over the years, integration of nanotechnology, and ending with a detailed review of the most important applications of this therapeutic approach.

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Section: Malignant Diseasesmentioning

confidence: 99%

Photodynamic Therapy—An Up-to-Date Review

2021

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“…The Stöber method was applied to synthesize the nearly mono-disperse and spherical SiO2 nanoparticles [21], [22]. As previously established, altering the dissolvent (methanol or ethanol), quantity for participating ingredients in the reacting process (H2O, TEOS), as well as ammonium hydroxide (NH4OH) catalyst resulted in SiO2-nanoparticle production with particle sizes ranging from 10 to 450 nm.…”

Section: Scattering Computationmentioning

confidence: 99%

The effects of SiO2@Y2O2S:Eu3+ phosphor on the optic characteristics of white light-emitting diodes

Bui

2022

IJEECS

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The study investigated the effectiveness of coating silica nanoparticles (SiO2) and resin-silica nanocomposites poly methyl methacrylate (PMMA)-silicaover the surface of Y2O2S:Eu3+ red phosphors. The purpose of this surface coating is to enhance the optical properties, including the photoluminescence (PL) and long-term stability, of Y2O2S:Eu3+. Two methods used to coat the phosphor with 5-mm silica nanoparticles are dip-coating and sol-gel (Stöber) methods. SiO2 nanoparticles were formed via hydrolysis and condensation reactions, while radical polymerization was performed to fabricate the poly (1-vinyl-2-pyrrolidone). The Y2O2S:Eu3+ surface coating of PMMA-silica composite was performed via two reactions. One is the reaction of SiO2 nanoparticles with methyl methacrylate (MMA) monomer, and the other is MMA-tetraethyl orthosilicate (TEOS) reaction. The results showed that by using the latter method, Y2O2S:Eu3+ yielded better PL and long-term stability. Additionally, surface coating with the PMMA-SiO2 nanocomposite using the second technique resulted in 5% enhancement in PL and stabilized the cathode luminescence (CL) intensity of Y2O2S:Eu3+, compared to those properties of uncoated Y2O3S:Eu3+ phosphor particles.

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“…As far as we know, only a recent study performed the clinical treatment of CIN with Pcs [24]. PDT was performed using a chitosan NP containing chlorocyan-aluminum Pc in patients with CIN1 and CIN2.…”

Section: Clinical Studiesmentioning

confidence: 99%

“…A PS should ideally have the following key features: (1) be a pure compound; (2) present a long life of the triplet reactive excited species generated by the photoactive pathways (greater than 500 ns), enough to react with molecular oxygen and induce ROS production; (3) present a strong absorption peak in the red to near-infrared spectral region (NIR) (between 650 and 800 nm) because the absorption of single photons with wavelengths longer than 800 nm does not provide enough energy to excite oxygen to its singlet state. Additionally, the NIR is used because most tissues transmit light reasonably well in this spectral domain; (4) present a substantial triplet quantum yield leading to good production of ROS upon irradiation; (5) no dark toxicity and relatively rapid clearance from normal tissues, thereby minimizing the side effects of PDT; and (6) present good solubility and biocompatibility [23][24][25][26][27][28][29]. Since the discovery of PDT, continuous efforts have been made to identify new ideal PS with this set of characteristics.…”

Section: Introductionmentioning

confidence: 99%

Phthalocyanine and Its Formulations: A Promising Photosensitizer for Cervical Cancer Phototherapy

et al. 2021

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Cervical cancer is one of the most common causes of cancer-related deaths in women worldwide. Despite advances in current therapies, women with advanced or recurrent disease present poor prognosis. Photodynamic therapy (PDT) has emerged as an effective therapeutic alternative to treat oncological diseases such as cervical cancer. Phthalocyanines (Pcs) are considered good photosensitizers (PS) for PDT, although most of them present high levels of aggregation and are lipophilic. Despite many investigations and encouraging results, Pcs have not been approved as PS for PDT of invasive cervical cancer yet. This review presents an overview on the pathophysiology of cervical cancer and summarizes the most recent developments on the physicochemical properties of Pcs and biological results obtained both in vitro in tumor-bearing mice and in clinical tests reported in the last five years. Current evidence indicates that Pcs have potential as pharmaceutical agents for anti-cervical cancer therapy. The authors firmly believe that Pc-based formulations could emerge as a privileged scaffold for the establishment of lead compounds for PDT against different types of cervical cancer.

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Clinical treatment of intra-epithelia cervical neoplasia with photodynamic therapy

Cited by 13 publications

References 23 publications

Photodynamic Therapy—An Up-to-Date Review

Photodynamic Therapy—An Up-to-Date Review

The effects of SiO2@Y2O2S:Eu3+ phosphor on the optic characteristics of white light-emitting diodes

Phthalocyanine and Its Formulations: A Promising Photosensitizer for Cervical Cancer Phototherapy

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