Clinical translation of metal–organic frameworks

Tyagi, Nisha; Wijesundara, Yalini H.; Gassensmith, Jeremiah J.; Popat, Amirali

doi:10.1038/s41578-023-00608-3

Cited by 17 publications

(8 citation statements)

References 10 publications

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“…Timeline illustrating the significant achievements in MOFs regarding drug and vaccine delivery and diagnosis applications. Recreated with permission from Nisha Tyagi et al Copyright 2023 Springer Nature Limited.…”

Section: Future Direction: How Research Can Be Streamlined Toward Bui...mentioning

confidence: 99%

The Promise and Potential of Metal–Organic Frameworks and Covalent Organic Frameworks in Vaccine Nanotechnology

Wijesundara,

Howlett,

Kumari

et al. 2024

Chem. Rev.

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The immune system's complexity and ongoing evolutionary struggle against deleterious pathogens underscore the value of vaccination technologies, which have been bolstering human immunity for over two centuries. Despite noteworthy advancements over these 200 years, three areas remain recalcitrant to improvement owing to the environmental instability of the biomolecules used in vaccines�the challenges of formulating them into controlled release systems, their need for constant refrigeration to avoid loss of efficacy, and the requirement that they be delivered via needle owing to gastrointestinal incompatibility. Nanotechnology, particularly metal−organic frameworks (MOFs) and covalent organic frameworks (COFs), has emerged as a promising avenue for confronting these challenges, presenting a new frontier in vaccine development. Although these materials have been widely explored in the context of drug delivery, imaging, and cancer immunotherapy, their role in immunology and vaccine-related applications is a recent yet rapidly developing field. This review seeks to elucidate the prospective use of MOFs and COFs for biomaterial stabilization, eliminating the necessity for cold chains, enhancing antigen potency as adjuvants, and potentializing needle-free delivery of vaccines. It provides an expansive and critical viewpoint on this rapidly evolving field of research and emphasizes the vital contribution of chemists in driving further advancements. CONTENTS 1. Introduction to Vaccines and Immuno-Therapeutics and Current Limitations in the Landscape of Vaccine Technology 3013 2. Unique Structural Features of MOFs/COFs 3015 3. Advantages of Using MOFs/COFs To Fill the Gap in Current Vaccine Technology 3017 3.1. Thermodynamic Stability of MOFs 3017 3.2. Kinetic Lability 3019 3.3. Functional Modification 3019 3.4. Needle-Free Delivery 3019 4.

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Section: Future Direction: How Research Can Be Streamlined Toward Bui...mentioning

confidence: 99%

The Promise and Potential of Metal–Organic Frameworks and Covalent Organic Frameworks in Vaccine Nanotechnology

Wijesundara,

Howlett,

Kumari

et al. 2024

Chem. Rev.

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“…Particularly in the area of biomedical engineering, MOFs showcase a series of merits. 31–35 For instance, MOFs can serve as effective carriers for maximized drug loading, 36,37 or as enzyme-mimetic catalysts (Enz-Cats) for the therapy of various diseases. 38,39 Besides, the bactericidal metal ions and antimicrobial linkers in the MOFs are powerful enough to eliminate bacteria.…”

Section: Introductionmentioning

confidence: 99%

“…Thirdly, pure MOFs cannot satisfy blood purification devices and clinical conditions. 35 Especially for practical HP, crystal materials hardly resist the flow friction, bringing about fracture and even decomposition. Therefore, current studies on MOFs for simulated HD and HP all use MOF/polymer composites, which undoubtedly reduces the adsorption efficiency of pure MOFs.…”

Section: Introductionmentioning

confidence: 99%

Metal–organic framework-based adsorbents for blood purification: progress, challenges, and prospects

Wang,

Cheng,

Sun

et al. 2024

J. Mater. Chem. B

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“…14−17 These include ample surface area, high porosity, robust adsorption capabilities, and structural stability. 18,19 In recent years, research on sensors based on MOFs has rapidly expanded. 20−23 Compared to traditional materials used in EC biosensors (such as graphene oxides or transition metal oxides), 24−26 MOF-based biosensors consistently exhibit exceptionally high sensitivity and ultralow detection limits.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Metal–organic framework (MOF), a novel porous crystalline material constructed through coordination bonds between organic ligands and inorganic metals, boasts several unique advantages. − These include ample surface area, high porosity, robust adsorption capabilities, and structural stability. , In recent years, research on sensors based on MOFs has rapidly expanded. − Compared to traditional materials used in EC biosensors (such as graphene oxides or transition metal oxides), − MOF-based biosensors consistently exhibit exceptionally high sensitivity and ultralow detection limits. − Consequently, constructing PEC biosensors on MOF substrates holds immense potential. Furthermore, due to the high porosity of MOFs, they find extensive application in separation and water purification studies. , Inspired by this, modifying electrodes with MOFs and leveraging their porous structures to selectively filter out large biomolecules during biosensing represents a rational approach to achieving anticontamination effects.…”

Section: Introductionmentioning

confidence: 99%

Hydrogel/MOF Dual-Modified Photoelectrochemical Biosensor for Antibiofouling and Biocompatible Dopamine Detection

Xu,

Lu,

Zhang

2024

Langmuir

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For accurate in vivo detection, nonspecific adsorption of biomacromolecules such as proteins and cells is a severe issue. The adsorption leads to electrode passivation, significantly compromising both the sensitivity and precision of sensing. Meanwhile, common antibiofouling modifications, such as polymer coatings, still grapple with issues related to biocompatibility, electrode passivation, and miniaturization. Herein, we propose a composite antibiofouling coating strategy based on zwitterionic metal−organic frameworks (Z-MOFs) and a combination of acrylamide hydrogels. On a well-designed TiO 2 /Z-MOF/hydrogel photoelectrode, we achieve highly sensitive and selective detection of dopamine in complex biological environments. The hydrogel's three-dimensional porous structure combined with unique microporous architecture of Z-MOF ensures effective sieving of interfering macromolecules while preserving efficient small molecules and electron transport. This innovative approach paves the way for constructing miniature, in vivo antibiofouling sensors for molecule monitoring in living organisms with complicated chemical environments.

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Clinical translation of metal–organic frameworks

Cited by 17 publications

References 10 publications

The Promise and Potential of Metal–Organic Frameworks and Covalent Organic Frameworks in Vaccine Nanotechnology

The Promise and Potential of Metal–Organic Frameworks and Covalent Organic Frameworks in Vaccine Nanotechnology

Metal–organic framework-based adsorbents for blood purification: progress, challenges, and prospects

Hydrogel/MOF Dual-Modified Photoelectrochemical Biosensor for Antibiofouling and Biocompatible Dopamine Detection

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