Clinical trajectories of hand function impairment in systemic sclerosis: an unmet clinical need across disease subsets
Enrico De Lorenzis,
Vishal Kakkar,
Stefano Di Donato
et al.
Abstract:BackgroundHand involvement is an early manifestation of systemic sclerosis (SSc), culprit of diagnosis and classification, and recognised major driver of disability. Impairment of hand function burdens both limited and diffuse cutaneous subsets and therefore could be targeted as ‘basket’ endpoint in SSc. Nevertheless, its natural history in current standard of care is not well characterised, limiting the design of targeted trials. The aim of this study is to describe prevalence, natural history and clinical fa… Show more
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