Clinical Toxicity of Thiouracil *

Streptomycin in the Treatment of Infections

“…However, even the most careful manual epilation failed to cure the infection in many cases. 4. Although the fungicides failed to cure in the majority of cases, they apparently served in most instances to prevent spread of the infection to new areas of the scalp.…”

The Preparation of Some 6-Substituted-2-thiouracils1

“…soc. chim., [4] 1$, 279 (1913). <0.1 " When crystallized from dilute dioxane a strong mercaptan odor was noticed indicating that some decomposition was occurring.…”

“…The synthesis of 5-and 6-substituted-2-thiouracils from /3-oxoesters and thiourea has been reported recently by Anderson, et al2 These compounds were evaluated in rats as antithyroid drugs3 and several were found to be more active than the parent compound, 2-thiouracil, which has been used extensively for the treatment of hyperthyroidism in man. 4 In this paper several new 6substituted-2-thiouracils are described. Some are closely related to the more active compounds previously reported.2 Others are of new types in which various heterocycles are used as substituents.…”

Risk and medical ethics.

“…Yet when thiourea derivatives had been found to inhibit thyroid activity in animals, thiouracil was widely used to control hyperthyroidism in Man, either to avoid the need for subtotal thyroidectomy, or at least to restore the thyroid activity to normal at the time of operation. Within a few years ofits introduction, however, three reports (2,3,4) had appeared, which showed a mortality from agranulocytosis of 0.4 per cent of patients treated with thiouracil; a risk 25 times greater than Girdwood's highest value. If safer and equally effective derivatives of thiourea had not rapidly become available, the problem would have.…”