Clinical Therapeutic Effects of Aspirin in Combination with Fufang Danshen Diwan, a Traditional Chinese Medicine Formula, on Coronary Heart Disease: A Systematic Review and Meta-Analysis

Abstract

Background/Aims: Coronary heart disease is characterized by vascular stenosis or occlusion resulting in myocardial ischemia, hypoxia and necrosis. In China, the combination of aspirin and Fufang Danshen Diwan (FDD), a traditional Chinese medicine formula, has been suggested in the treatment of coronary heart disease. There have been several studies comparing the effectiveness of aspirin alone and in combination with FDD to treat coronary artery disease; however, it remains unclear whether combined aspirin therapy is superior. This study was thus designed to clarify this issue through a systematic review and meta-analysis. Methods: Databases including PubMed, EMBASE, China National Knowledge Infrastructure (CNKI) database, Wanfang Data and VIP Information were searched. Papers were reviewed systematically by two researchers and analyzed using Cochrane software Revman 5.1. Results: Fourteen randomized controlled trials enrolling 1367 subjects were included. Meta-analyses revealed that aspirin in combination with FDD was significantly more effective at alleviating angina pectoris and improving electrocardiogram (ECG) results relative to aspirin therapy alone, reflected by the summary effects for the clinical markedly effective (OR = 2.45; 95% CI 1.95-3.08) and the total effective (OR = 3.92; 95% CI 2.87-5.36) rates. In addition, combined aspirin and FDD was significantly more efficacious than aspirin monotherapy at improving blood lipid levels, as indicated by the following outcomes: 1) reduction of TC level (SMD −1.12; 95% CI −1.49 to −0.76); 2) reduction of TG level (SMD −0.94; 95% CI −1.15 to -0.74); 3) reduction of LDL level (SMD -0.68; 95% CI -0.88 to -0.48); and 4) improvement of HDL level (SMD 0.52; 95% CI 0.04 to 0.99 ). No serious adverse events were reported in any of the included trials. Conclusion: The present meta-analysis demonstrated that aspirin in combination with FDD was more effective than aspirin alone for treating coronary heart disease. More full-scale randomized clinical trials with reliable designs are recommended to further evaluate the clinical benefits and long-term effectiveness of FDD for the treatment of coronary heart disease.

Mining of candidate genes involved in the biosynthesis of dextrorotatory borneol in Cinnamomum burmannii by transcriptomic analysis on three chemotypes

“…Transdermal administration is mainly used to ease pain resulting from wounds, injuries, burns, cuts and similar. When administered orally, D-borneol is widely used to treat cardiovascular diseases, including stroke, coronary heart disease and angina pectoris, as an indispensable ingredient in many traditional Chinese herbal formulas, such as Angong Niuhuang pill, Suxiao Jiuxin pill and Fufang Danshen pill (or Compound Danshen) (Chai et al, 2019;Chen et al, 2019;Huang et al, 2016;Liang et al, 2018;Ren et al, 2018).…”

Understanding the Mechanistic Contribution of Herbal Extracts in Compound Kushen Injection With Transcriptome Analysis

“…At present many complex and chronic diseases rely on therapies that combine modern pharmaceuticals. A similar multiple-herb strategy known as “Fufang” is an essential component in traditional Chinese medicine (TCM) theory and is used to achieve better therapeutic results, and reduce side effects and herbal toxicity (1, 2). As a result of thousands of years' of accumulated clinical practice, TCM has more than 100,000 formulae and abundant experience that has contributed to an understanding of which herbs should be combined in particular circumstances, herein referred to as herbal compatibility (3, 4).…”

AFC1 Compound Attenuated MI/R-Induced Ventricular Remodeling via Inhibiting PDGFR and STAT Pathway

“…, has been widely used either alone or in combination with other herbal ingredients for patients with IHD and other cardiovascular diseases in both China and other countries because of its efficacy in improving microcirculation and protecting against myocardial ischemia (Cheng, 2007). For example, results from meta-analysis demonstrated the potential benefits of compound Danshen dripping pill (CDDP) for treating coronary heart disease (Luo et al, 2015; Huang et al, 2016). However, the overall quality of the evidences in the systematic reviews was poor and high-quality evidence is warranted to support the clinical application of CDDP in treating IHD.…”