Clinical symptoms predict concurrent social and global functioning in an early psychosis sample

Abstract

Clinical domains such as negative symptoms and social interaction anxiety significantly contribute to an optimal model predicting outcome during the early phase of a psychotic disorder. These clinical features may also provide useful markers of an individual's capacity for social participation. Clinical implications include the need for early targeted intervention to address social anxiety and negative psychotic symptoms to facilitate optimum patient outcome.

Negative symptoms in first‐episode psychosis: Clinical correlates and 1‐year follow‐up outcomes in London Early Intervention Services

“…Higher NS at baseline were associated with worse functioning at 1-year follow-up as reflected by the GAF-d scores. This finding is consistent with most FEP studies to date that show NS as a critical determinant of both global and social functioning (Cacciotti-Saija et al, 2015) and real-world functioning (Robertson et al, 2014), for at least 2 years after the FEP (Bergé et al, 2016). Recent research also supports this link in individuals at clinical risk of psychosis (Meyer et al, 2014).…”

Task Performance Modulates Functional Connectivity Involving the Dorsolateral Prefrontal Cortex in Patients with Schizophrenia

“…The disorder is often described in terms of positive symptoms, such as hallucinations and delusions, and negative symptoms, such as reduced emotional expression and lack of motivation (Bozikas and Andreou, 2011 ). In addition, recent researches have suggested that working memory dysfunction may be a core component of schizophrenia (Lee and Park, 2005 ; Vu et al, 2013 ; Cacciotti-Saija et al, 2015 ; Jiang et al, 2015 ; Mourik et al, 2015 ; Schwarz et al, 2016 ), and that such dysfunction may be the result of abnormal activity in a specific brain network (Glahn et al, 2005 ; Minzenberg et al, 2009 ; Jiang and Zhou, 2012 ) involving the dorsolateral prefrontal cortex (DLPFC) (Goldman-Rakic, 1999 ). However, results regarding the contribution of this region remain inconsistent.…”

Topology predicts long-term functional outcome in early psychosis

“…Patients from groups B and C displayed high levels of negative symptoms at baseline, though these symptoms remain high only in group C. This may be linked to a different illness profile and neurobiological basis between groups B and C, which is actually in line with our results showing that they have distinct metabolic profiles. Group C may consist of patients with persistent trait-related negative symptoms, known indicators of poor psychosocial outcome [51][52][53]. The GPx activity was particularly high in group C, suggesting that they may benefit from antioxidant add-on therapy [35] such N-acetyl-cysteine, which improves negative symptoms [54,55].…”